Zobrazeno 1 - 10 of 86 pro vyhledávání: '"Michael Sinz"'
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Akademický článek
A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk
Autor: Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami‐Hodjegan, Brian J. Schmidt, Lu Gaohua, Aleksandra Galetin
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 11, Pp 1856-1869 (2024)
Abstract Breastfeeding is the most complete nutritional method of feeding infants, but several impediments affect the decision to breastfeed, including questions of drug safety for medications needed during lactation. Despite recent FDA guidance, few
Externí odkaz: https://doaj.org/article/7b1e0da885c44b1aa5e125279d3a9ef4
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Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III
Autor: L.V.J. Sankara Sivaprasad, Bokka Venkata Murali, T. Thanga Mariappan, Sushma Basavanthappa, Avinash Annasao Hadambar, Vijaykumar Kuchibhotla, Avisek Deyati, Bradley A. Zinker, Gowtham Raj Gunti, Manjunath Ramarao, Sagnik Chatterjee, Shashyendra Singh Gautam, Yueping Zhang, Tanvi Naik, Hong Shen, Sambuddho Mukherjee, Michael Sinz
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 376:29-39
Expression and functional changes in the organic anion transporting polypeptide (OATP)-multidrug resistance-associated protein (MRP) axis of transporters are well reported in patients with nonalcoholic steatohepatitis (NASH). These changes can impact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c586217f3e68fc4669c5919c8c6bfed3
https://doi.org/10.1124/jpet.120.000291
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6
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression
Autor: R. Marcus Fancher, Hong Shen, Pawel D. Puszczalo, Shen-Jue Chen, Xue-Qing Chen, David J. Shuster, Cliff Chen, Zheng Yang, Yueping Zhang, Michael Sinz
Publikováno v: The Journal of pharmacology and experimental therapeutics. 375(1)
Organic anion-transporting polypeptide (OATP) 1B induction is an evolving mechanism of drug disposition and interaction. However, there are contradictory reports describing OATP1B expression in hepatocytes and liver biopsies after administration of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5fe69c064b860f01c0a6c8176ec465
https://pubmed.ncbi.nlm.nih.gov/32719071
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Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition
Autor: Michael Sinz, Yang Hong, Jinping Gan, R. Marcus Fancher, Yurong Lai, Xiaomei Gu, Lifei Wang, Yuan Tian, Hong Shen
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 48(8)
Despite a recent expansion in the recognition of coproporphyrin’s (CP9s) potential utility as an endogenous biomarker of OATP1B activity, there have been few detailed studies of C9s pharmacokinetic behavior and an overall poor understanding of its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accb652d3840e2199ecade397f8fa73f
https://pubmed.ncbi.nlm.nih.gov/32482623
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8
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Autor: Mahesh Paschapur, Jeffrey M. Brown, Tanmaya Bastia, Lawrence R. Marcin, Jayakumar Sankara Warrier, Srinivasan Thangathirupathy, Joanne J. Bronson, Raja Reddy Kallem, Huiping Zhang, Jyoti Gulia, Alda Fernandes, Digavalli V. Sivarao, Deborah Keavy, Amy Newton, Jianqing Li, Pattipati S. Naidu, Kuchibhotla Vijaya Kumar, James Kempson, Michael R. Weed, Rick L. Pieschl, Mark Bookbinder, Charlie F. Albright, Kimberly Newberry, Yu-Wen Li, Dalton King, Manjunath Ramarao, Jean Simmermacher, Linda J. Bristow, Meenakshee Sinha, Eric Shields, Lorin A. Thompson, John E. Macor, Charulatha Sanmathi, Imadul Islam, B.N. Srikumar, Richard E. Olson, John D. Graef, Arvind Mathur, Narasimharaju Kalidindi, Joseph Polino, Michael Sinz, Thaddeus F. Molski, Jayant Aher, Reeba K. Vikramadithyan
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 363:377-393
(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3S,4S)-3-fluoro-1-((R)-1-(4-methylbenzyl)-2-oxopyrrolidin-3-yl)piperidin-4-yl)phenyl dihydrogen phosphate (BMS-98
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fc12be7607ec5d5401f625fdca24cd2
https://doi.org/10.1124/jpet.117.242784
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10
Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate
Autor: Punit Marathe, Michael Sinz, Erika Panfen, Hong Shen, Yueping Zhang, Marcus Fancher
Publikováno v: Molecular pharmaceutics. 16(6)
Identification of a selective inhibitor of organic anion transporting polypeptide (OATP) 1B1 is critical in order to determine the contribution of OATP1B1-mediated uptake of investigational drugs into human hepatocytes for successful in vitro-to-in v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37949e404d9294c9b2362eba7b09f71d
https://pubmed.ncbi.nlm.nih.gov/31039308
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