Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michael Silkes"'
Autor:
Peter S. Hammerman, Kwok-Kin Wong, Richard A. Young, Nathanael S. Gray, Hideo Watanabe, Adam J. Bass, Matthew Meyerson, Takeshi Shimamura, Li Tan, Tenny Mudianto, Michael Silkes, Neermala Poudel-Neupane, Sook-Hee Hong, Tae-Jung Kim, Tinghu Zhang, Yichen Wang, Tianxia Li, Alan L. Leggett, Tiffany Tavares, Hideki Terai, Wankun Chen, Haikuo Zhang, Kevin Rhee, Shuai Li, Ting Chen, Bruno Bockorny, Kevin A. Buczkowski, Nicholas Kwiatkowski, Brian J. Abraham, Camilla L. Christensen, Yvonne Li, Kapsok Li, Maria Rusan
Supplementary Figures 1-10 and corresponding legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dc8837ec3b000f674813205736cf1c
https://doi.org/10.1158/2159-8290.22533643
https://doi.org/10.1158/2159-8290.22533643
Autor:
Maria Rusan, Kapsok Li, Wankun Chen, Richard A. Young, Nathanael S. Gray, Tenny Mudianto, Tiffany Tavares, Michael Silkes, Matthew Meyerson, Shuai Li, Bruno Bockorny, Yvonne Y. Li, Kevin A. Buczkowski, Brian J. Abraham, Sook Hee Hong, Tianxia Li, Li Tan, Hideki Terai, Hideo Watanabe, Alan L. Leggett, Ting Chen, Peter S. Hammerman, Camilla L. Christensen, Tae-Jung Kim, Nicholas Kwiatkowski, Kevin Rhee, Yichen Wang, Neermala Poudel-Neupane, Haikuo Zhang, Adam J. Bass, Kwok-Kin Wong, Takeshi Shimamura, Tinghu Zhang
Publikováno v:
PMC
Rusan, M, Li, K, Li, Y, Christensen, C L, Abraham, B J, Kwiatkowski, N, Buczkowski, K A, Bockorny, B, Chen, T, Li, S, Rhee, K, Zhang, H, Chen, W, Terai, H, Tavares, T, Leggett, A L, Li, T, Wang, Y, Zhang, T, Kim, T J, Hong, S H, Poudel-Neupane, N, Silkes, M, Mudianto, T, Tan, L, Shimamura, T, Meyerson, M, Bass, A J, Watanabe, H, Gray, N S, Young, R A, Wong, K K & Hammerman, P S 2018, ' Suppression of adaptive responses to targeted cancer therapy by transcriptional repression ', Cancer Discovery, vol. 8, no. 1, pp. 59-73 . https://doi.org/10.1158/2159-8290.CD-17-0461
Rusan, M, Li, K, Li, Y, Christensen, C L, Abraham, B J, Kwiatkowski, N, Buczkowski, K A, Bockorny, B, Chen, T, Li, S, Rhee, K, Zhang, H, Chen, W, Terai, H, Tavares, T, Leggett, A L, Li, T, Wang, Y, Zhang, T, Kim, T J, Hong, S H, Poudel-Neupane, N, Silkes, M, Mudianto, T, Tan, L, Shimamura, T, Meyerson, M, Bass, A J, Watanabe, H, Gray, N S, Young, R A, Wong, K K & Hammerman, P S 2018, ' Suppression of adaptive responses to targeted cancer therapy by transcriptional repression ', Cancer Discovery, vol. 8, no. 1, pp. 59-73 . https://doi.org/10.1158/2159-8290.CD-17-0461
Acquired drug resistance is a major factor limiting the effectiveness of targeted cancer therapies. Targeting tumors with kinase inhibitors induces complex adaptive programs that promote the persistence of a fraction of the original cell population,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bf5c7f5ce83f47eeef05e3630ed1a2
https://europepmc.org/articles/PMC5819998/
https://europepmc.org/articles/PMC5819998/
Autor:
Ting Chen, Nicholas Kwiatkowski, Bruno Bockorny, Maria Rusan, Li Tan, Camilla L. Christensen, Haikuo Zhang, Peter S. Hammerman, Matthew Meyerson, Nathanael S. Gray, Shuai Li, Tae Jung Kim, Brian J. Abraham, Hideo Watanabe, Kevin A. Buczkowski, Michael Silkes, Tenny Mudianto, Kapsok Li, Yvonne Y. Li, Richard A. Young, Tinghu Zhang, Hideko Terai, Kwok-Kin Wong, Takeshi Shimamura, Tiffany Tavares
Publikováno v:
Cancer Research. 77:15-15
Tumor cells become dependent on the expression of key genes that drive hallmark tumor traits, but these “addictions” also represent potential vulnerabilities for therapeutic intervention. Treating tumor cells with a small molecule inhibitor of th