Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael Siedler"'
Autor:
Shifeng Yu, Yongjia Wu, Shuyu Wang, Michael Siedler, Peter M. Ihnat, Dana I. Filoti, Ming Lu, Lei Zuo
Publikováno v:
Biosensors, Vol 12, Iss 6, p 422 (2022)
Calorimeters, which can be used for rapid thermal characterization of biomolecules, are getting intense attention in drug development. This paper presents a novel MEMS-based differential scanning calorimeter (DSC) for direct thermal characterization
Externí odkaz:
https://doaj.org/article/653ca2d886614184b153e9f5a89956ac
Autor:
Shifeng Yu, Yongjia Wu, Shuyu Wang, Michael Siedler, Peter M. Ihnat, Dana I. Filoti, Ming Lu, Lei Zuo
Publikováno v:
Biosensors; Volume 12; Issue 6; Pages: 422
Calorimeters, which can be used for rapid thermal characterization of biomolecules, are getting intense attention in drug development. This paper presents a novel MEMS-based differential scanning calorimeter (DSC) for direct thermal characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d138bae9c7af3e1b7f4575da6671b7
https://hdl.handle.net/10919/110905
https://hdl.handle.net/10919/110905
Autor:
Michael Siedler, Christine Rinn
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Sterile-grade filtration is a key unit operation during processing of biotherapeutics. However, selecting the optimal filter type and configuration could be a challenging task. Here we present a case study of a systematic risk-based approach for esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59bf12a562a4eca0ede92fb063695d67
https://doi.org/10.1007/978-3-030-31415-6_23
https://doi.org/10.1007/978-3-030-31415-6_23
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Formulation scientists are confronted with challenges arising from the increasing diversity of molecule formats and their functionality such as antibody-drug conjugates, fusion molecules, as well as increasing expectations by authorities for an in-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0664dadcb97c268ff85e187f75490cbf
https://doi.org/10.1007/978-3-030-31415-6_13
https://doi.org/10.1007/978-3-030-31415-6_13
Publikováno v:
Chemie Ingenieur Technik. 89:987-994
The aggregation process and conformational change of two monoclonal antibodies, monitored by in situ measuring techniques during stressing in a well-defined flow field, was experimentally studied. The increase in turbidity, which was detected by in-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d54f49c4135b6730f57d324f56701495
https://doi.org/10.1002/cite.201600161
https://doi.org/10.1002/cite.201600161
Autor:
Michael Siedler, Stylianos Michalakis, Angelika Freitag, John F. Carpenter, Theodore W. Randolph, Julia Engert, Martin Biel, Maliheh Shomali, Gerhard Winter, Zehra Kaymakcalan
Publikováno v:
Pharmaceutical Research. 32:430-444
The potential contribution of protein aggregates to the unwanted immunogenicity of protein pharmaceuticals is a major concern. In the present study a murine monoclonal antibody was utilized to study the immunogenicity of different types of aggregates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9412980ea3e424b08b83def6db9e6380
https://doi.org/10.1007/s11095-014-1472-6
https://doi.org/10.1007/s11095-014-1472-6
Autor:
Tae-Gyun Kim, Ulf M. E. Wikesjö, Kyoo-Sung Cho, Jung-Kiu Chai, Susanne D. Pippig, Michael Siedler, Chong-Kwan Kim
Publikováno v:
Journal of Clinical Periodontology. 36:589-597
Recombinant human growth/differentiation factor-5 (rhGDF-5) is being evaluated as a candidate therapy in support of periodontal regeneration. The objective of this study was to evaluate cementum and alveolar bone formation, and aberrant healing event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d5d7e21c76f8b7bbf525903c88ac1e
https://doi.org/10.1111/j.1600-051x.2009.01420.x
https://doi.org/10.1111/j.1600-051x.2009.01420.x
Autor:
Susanne D. Pippig, Michael Siedler, Ulf M.E. Wikesjö, Chong-Kwan Kim, Andreas Schuetz, Samuel Herberg, Carola Dony
Publikováno v:
Journal of Clinical Periodontology. 35:976-984
Aim Biomaterials are often applied in periodontal therapy; however, not always well adapted for tissue regeneration. The objective of this study was to evaluate the physico-chemical properties and biocompatibility of an injectable, in situ setting co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdf4fb3f831776d25ac7a4f1b9afdf6
https://doi.org/10.1111/j.1600-051x.2008.01323.x
https://doi.org/10.1111/j.1600-051x.2008.01323.x
Publikováno v:
Quality by Design for Biopharmaceutical Drug Product Development ISBN: 9781493923151
CMC development of biotherapeutics may be negatively impacted by poor drug-like properties, including low solubility, high viscosity, and high aggregation. Typically, formulation development of such products involved accommodating any molecular candi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::126b9d7e415b379d1bebdedccfc379e1
https://doi.org/10.1007/978-1-4939-2316-8_5
https://doi.org/10.1007/978-1-4939-2316-8_5
Autor:
Michael Siedler, Andreas Schütz, Sylke Poehling, Carola Dony, Susanne D. Pippig, Klaus Hellerbrand
Publikováno v:
Journal of Periodontology. 77:1582-1590
MD05 consists of beta-tricalcium phosphate (beta-TCP) coated with recombinant human growth/differentiation factor-5 (rhGDF-5) and is under evaluation as an osteoinductive and osteoconductive bone graft material for use in dental and maxillofacial app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0c6d6f66d78579baab3593ba23c519
https://doi.org/10.1902/jop.2006.050328
https://doi.org/10.1902/jop.2006.050328