Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Michael Shum"'
Autor:
Vincent Gutierrez, Doyeon Kim-Vasquez, Michael Shum, Qihong Yang, Dante Dikeman, Stan G. Louie, Orian S. Shirihai, Hidekazu Tsukamoto, Marc Liesa
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103052- (2024)
Acute liver failure caused by alcoholic hepatitis (AH) is only effectively treated with liver transplantation. Livers of patients with AH show a unique molecular signature characterized by defective hepatocellular redox metabolism, concurrent to hepa
Externí odkaz:
https://doaj.org/article/f50c083d6e6d4eaebcac3b870c9ad34e
Autor:
Kevin Gonthier, Cindy Weidmann, Line Berthiaume, Cynthia Jobin, Aurélie Lacouture, Camille Lafront, Mario Harvey, Bertrand Neveu, Jérémy Loehr, Alain Bergeron, Yves Fradet, Louis Lacombe, Julie Riopel, Éva Latulippe, Chantal Atallah, Michael Shum, Jean‐Philippe Lambert, Frédéric Pouliot, Martin Pelletier, Étienne Audet‐Walsh
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2109-2125 (2023)
The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program. Intriguingly, AR regulates cytoplasmic isocitrate dehydrogenase 1 (IDH1), but not its mitoc
Externí odkaz:
https://doaj.org/article/b60b3bf0f71f4ae9996565ed221a4aac
Autor:
Zhi Zhang, Fernando M. C. V. Reis, Yanlin He, Jae W. Park, Johnathon R. DiVittorio, Nilla Sivakumar, J. Edward van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Torpor is a state of reduced metabolism and body temperature that conserves energy when food is scarce. Here the authors show that estrogen-sensitive neurons in the hypothalamus regulate torpor in mice, maintaining torpor in both sexes but initiating
Externí odkaz:
https://doaj.org/article/7b9ecf04f1a846dda1413b72774ce3f8
Autor:
Michael Shum, Mayuko Segawa, Raffi Gharakhanian, Ana Viñuela, Matthew Wortham, Siyouneh Baghdasarian, Dane M. Wolf, Samuel B. Sereda, Laura Nocito, Linsey Stiles, Zhiqiang Zhou, Vincent Gutierrez, Maike Sander, Orian S. Shirihai, Marc Liesa
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101403- (2022)
Objective: The contribution of beta-cell dysfunction to type 2 diabetes (T2D) is not restricted to insulinopenia in the late stages of the disease. Elevated fasting insulinemia in normoglycemic humans is a major factor predicting the onset of insulin
Externí odkaz:
https://doaj.org/article/9dc2c70f85334be6a42fd766bfb0b160
Publikováno v:
Molecular Metabolism, Vol 50, Iss , Pp 101134- (2021)
Background: Mitochondrial oxidative function plays a key role in the development of non-alcoholic fatty liver disease (NAFLD) and insulin resistance (IR). Recent studies reported that fatty liver might not be a result of decreased mitochondrial fat o
Externí odkaz:
https://doaj.org/article/1809f2243fc9453f819fcd059882a14d
Autor:
Jennifer Ngo, Ilan Y. Benador, Alexandra J. Brownstein, Laurent Vergnes, Michaela Veliova, Michael Shum, Rebeca Acín-Pérez, Karen Reue, Orian S. Shirihai, Marc Liesa
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100243- (2021)
Summary: Mitochondria play a central role in lipid metabolism and can bind to lipid droplets. However, the role and functional specialization of the population of peridroplet mitochondria (PDMs) remain unclear, as methods to isolate functional PDMs w
Externí odkaz:
https://doaj.org/article/edfd860d7dca4c3cb26471e206507d87
Autor:
Alexandre Caron, Mathilde Mouchiroud, Nicolas Gautier, Sébastien M. Labbé, Romain Villot, Laurie Turcotte, Blandine Secco, Guillaume Lamoureux, Michael Shum, Yves Gélinas, André Marette, Denis Richard, David M. Sabatini, Mathieu Laplante
Publikováno v:
Molecular Metabolism, Vol 6, Iss 5, Pp 447-458 (2017)
Objective: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulates growth and metabolism. DEP-domain containing mTOR-interacting protein (DEPTOR) is par
Externí odkaz:
https://doaj.org/article/5b657b32a77b4cd28ae9600da645e499
Autor:
Lauren T. Hotaki, Anu Shrestha, Monica P. Bennett, Ivelisse L. Valdes, Sso H. Lee, Yinghua Wang, Dianne Spillman, Tina MacAulay, Melissa Hunt, Julie Gervais, Maral Mafi, Vincent Panetta, Yee Hoo Looi, Michael Shum, Eiman Atiek, Ricarda Meincke, Ulrich-Peter Rohr, Denize Ainbinder, Anat Boehm-Cagan, Osnat Luxenburg, Mateus Rodrigues Cerqueira, Laila Sofia Mouawad, Maria Fernanda Reis e Silva Thees, Krishna Prasad, R. Angelo de Claro
Publikováno v:
Therapeutic Innovation & Regulatory Science.
Autor:
null Kevin Gonthier, null Cindy Weidmann, null Line Berthiaume, null Cynthia Jobin, null Aurélie Lacouture, null Camille Lafront, null Mario Harvey, null Bertrand Neveu, null Jérémy Loehr, null Alain Bergeron, null Yves Fradet, null Louis Lacombe, null Julie Riopel, null Éva Latulippe, null Chantal Atallah, null Michael Shum, null Jean‐Philippe Lambert, null Frédéric Pouliot, null Martin Pelletier, null Étienne Audet‐Walsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ddf24a28337848105407f15371b6843
https://doi.org/10.1002/1878-0261.13441/v2/response1
https://doi.org/10.1002/1878-0261.13441/v2/response1
Autor:
Xia Yang, Marc Liesa, Megan G. Massa, Haley Hrncir, Jae W. Park, Stephanie M. Correa, Zhi Zhang, Douglas Arneson, Alexia M. Joseph, Michelle S. Reid, Arthur P. Arnold, Patricia Bunda, J. Edward van Veen, Laura G. Kammel, Michael Shum
Publikováno v:
Nature metabolism
Nature metabolism, vol 2, iss 4
Nature metabolism, vol 2, iss 4
Estrogen receptor a (ERa) signaling in the ventromedial hypothalamus (VMH) contributes to energy homeostasis by modulating physical activity and thermogenesis. However, the precise neuronal populations involved remain undefined. Here, we describe six