Výsledky vyhledávání - "Michael Sevestre"

Akademický článek

User-Centered Development and Testing of the Online Patient-Reported Outcomes, Burdens, and Experiences (PROBE) Survey and the myPROBE App and Integration With the Canadian Bleeding Disorder Registry: Mixed Methods Study

Autor: Federico Germini, Victoria Borg Debono, David Page, Victoria Zuk, Alexandra Kucher, Chris Cotoi, Nicholas Hobson, Michael Sevestre, Mark W Skinner, Alfonso Iorio

Publikováno v: JMIR Human Factors, Vol 9, Iss 1, p e30797 (2022)

BackgroundThe Patient-Reported Outcomes, Burdens, and Experiences (PROBE) questionnaire is a tool for assessing the quality of life and disease burden in people living with hemophilia. ObjectiveThe objectives of our study were (1) to assess the need

Externí odkaz: https://doaj.org/article/c89350bda0f04b42a3dc1c4f00dca729

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Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Autor: Sergej Ramusovic, Thorsten Lehr, Joerg Lippert, Stephan Schmidt, Mats O. Karlsson, Matthew M. Riggs, Peter A. Milligan, Juri Solodenko, Sebastian Frechen, Erik Sjögren, Donato Teutonico, Stephan Schaller, Michael Sevestre, Rolf Burghaus, Andreas Kovar, Valerie Nock, Jan Schlender, Alexander Staab, Andrea N. Edginton

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 12, Pp 878-882 (2019)
CPT: Pharmacometrics & Systems Pharmacology

Systems pharmacology integrates structural biological and pharmacological knowledge and experimental data, enabling dissection of organism and drug properties and providing excellent predictivity. The development of systems pharmacology models is a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159c6e2733bb84f0f5960b9c2ef63082
https://doaj.org/article/bdd5616c4719420aa5b5c08de592ba8c

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Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO

Autor: Kim L. R. Brouwer, Michael Cohen-Wolkowiez, Andrea N. Edginton, Kevin M. Watt, Michael Sevestre, Ping Zhao, Jeffrey S. Barrett

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology

Extracorporeal life support (e.g., dialysis, extracorporeal membrane oxygenation (ECMO)) can affect drug disposition, placing patients at risk for therapeutic failure. In this population, dose selection to achieve safe and effective drug exposure is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0e03b2677f49d9a8e433d9826bce5f
https://doi.org/10.1002/psp4.12338

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Development of a Physiology-Based Whole-Body Population Model for Assessing the Influence of Individual Variability on the Pharmacokinetics of Drugs

Autor: Karsten Dipl.-Ing. Höhn, Andrea N. Edginton, Stefan Willmann, Juri Solodenko, Jörg Lippert, Michael Sevestre, Wolfgang Weiss, Walter Schmitt

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 34:401-431

In clinical development stages, an a priori assessment of the sensitivity of the pharmacokinetic behavior with respect to physiological and anthropometric properties of human (sub-) populations is desirable. A physiology-based pharmacokinetic (PBPK)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3672c4f21ec088f45cb99317bc215a29
https://doi.org/10.1007/s10928-007-9053-5

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The integration of allometry and virtual populations to predict clearance and clearance variability in pediatric populations over the age of 6 years

Autor: Jeremiah D. Momper, Andrea N. Edginton, Michael Sevestre, Bhavank Shah

Publikováno v: Clinical pharmacokinetics. 52(8)

Pharmacokinetics play an integral role in the pediatric drug development process. The determination of pharmacokinetic parameters, particularly clearance, in different age groups directly informs dosing strategies for subsequent efficacy trials. Allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f1ce50ccfd4d7009f2f637152a0c57
https://pubmed.ncbi.nlm.nih.gov/23588537

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A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 2 (2011)

Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multi-scale by nature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d93ce3a6cb179c24d0834fda5ed7887

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Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Autor: Christoph Niederalt, Andrea N. Edginton, In-Jin Jang, Michael Sevestre, Stefan Willmann, Michaela Vossen

Publikováno v: Theoretical Biology and Medical Modelling, Vol 4, Iss 1, p 13 (2007)
Theoretical Biology & Medical Modelling

Background Drug-drug interactions resulting from the inhibition of an enzymatic process can have serious implications for clinical drug therapy. Quantification of the drugs internal exposure increase upon administration with an inhibitor requires und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75078974e7c306709e6651d1311e26b
https://doi.org/10.1186/1742-4682-4-13

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