Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Michael Sefkow"'
Autor:
Maria Joosten, Sebastian Ginzel, Christian Blex, Dmitri Schmidt, Michael Gombert, Cai Chen, René Martin Linka, Olivia Gräbner, Anika Hain, Burkhard Hirsch, Anke Sommerfeld, Anke Seegebarth, Uschi Gruber, Corinna Maneck, Langhui Zhang, Katharina Stenin, Henrik Dieks, Michael Sefkow, Carsten Münk, Claudia D. Baldus, Ralf Thiele, Arndt Borkhardt, Michael Hummel, Hubert Köster, Ute Fischer, Mathias Dreger, Volkhard Seitz
Publikováno v:
Molecular Oncology, Vol 10, Iss 8, Pp 1232-1244 (2016)
Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B‐cell lymphomas, although a subset of patients with refractory or relapsed B‐cell lymphoma achieved
Externí odkaz:
https://doaj.org/article/8c0b9682d8d14e8aab687d3b139b6d0e
Autor:
Günter Scherowsky, Michael Sefkow
Publikováno v:
CHIMIA, Vol 47, Iss 1-2 (1993)
Optically active 3-hydroxybutyric and 3-hydroxyhexanoic acids were transformed into 3,4-disubstituted and 3,3,4-trisubstituted 2-oxetanones using two different approaches. Diastereoselective alkylation was performed either on dioxanone enolates or on
Externí odkaz:
https://doaj.org/article/5b3fe81ea30e4ccb8cace96671370170
Autor:
Uschi Gruber, Mathias Dreger, Christian Blex, Matthias Hakelberg, Anett Marais, Frederick Gyapon Quast, Friedrich Kroll, Kathrin Bartho, Anna K. Schrey, Hubert Köster, Oliver Popp, Michael Sefkow, Jens Furkert, Ralf Schülein, Jenny Eichhorst, Sylvia Niquet, Simon Michaelis
Publikováno v:
ChemBioChem. 18:1639-1649
Unbiased chemoproteomic profiling of small-molecule interactions with endogenous proteins is important for drug discovery. For meaningful results, all protein classes have to be tractable, including G protein-coupled receptors (GPCRs). These receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c85a61c9c229a5b5b44adbfcfef7b4
https://doi.org/10.1002/cbic.201700152
https://doi.org/10.1002/cbic.201700152
Autor:
Anika Hain, Volkhard Seitz, Burkhard Hirsch, Uschi Gruber, Arndt Borkhardt, Mathias Dreger, René M. Linka, Olivia Gräbner, Corinna Maneck, Christian Blex, Sebastian Ginzel, Henrik Dieks, Carsten Münk, Claudia D. Baldus, Michael Hummel, Anke Seegebarth, Anke Sommerfeld, Katharina Stenin, Michael Gombert, Michael Sefkow, Maria Joosten, Hubert Köster, Dmitri Schmidt, Ute Fischer, Ralf Thiele, Cai Chen, Langhui Zhang
Publikováno v:
Molecular Oncology. 10:1232-1244
Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B-cell lymphomas, although a subset of patients with refractory or relapsed B-cell lymphoma achieved part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee822a4c719001cb8a3b5e21fa5066d1
https://doi.org/10.1016/j.molonc.2016.06.001
https://doi.org/10.1016/j.molonc.2016.06.001
Autor:
Michael Sefkow
Publikováno v:
Topics in Current Chemistry ISBN: 9783540211259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9f27aaec4dd4ba0293010c66346142c
https://doi.org/10.1007/b96884
https://doi.org/10.1007/b96884
Autor:
Olivia Y. Graebner, Hubert Koester, Simon Michaelis, Lisa von Kleist, Anna K. Schrey, Kathrin Bartho, Mathias Dreger, Friedrich Kroll, Yan Luo, Marén Schlief, Michael Sefkow
Publikováno v:
Journal of medicinal chemistry. 59(10)
Structurally related inhibitors of a shared therapeutic target may differ regarding potential toxicity issues that are caused by different off-target bindings. We devised a differential competition capture compound mass spectrometry (dCCMS) strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7badf2450bed879ae95b4f7d6a1c0b57
https://pubmed.ncbi.nlm.nih.gov/27074629
https://pubmed.ncbi.nlm.nih.gov/27074629
Publikováno v:
Synthetic Communications. 41:41-51
Cross-coupling reactions, such as Buchwald-Hartwig arylamination and direct intramolecular biaryl coupling by C–H activation, were carried out using various Palladium-N-heterocyclic carbenes (Pd–NHC) as catalysts. The yields were good to excellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::889898ed5c0bc054e5118021d9e915f5
https://doi.org/10.1080/00397910903531755
https://doi.org/10.1080/00397910903531755
Autor:
Anna K. Schrey, Mirko Glinski, Michael Sefkow, Jan Ungewiss, Yan Luo, Hubert Koester, Olivia Y. Graebner, Jenny J. Fischer, Mathias Dreger
Publikováno v:
Journal of Proteomics. 73:815-819
The functional isolation of proteome subsets based on small molecule–protein interactions is an increasingly popular and promising field in functional proteomics. Entire protein families may be profiled on the basis of their common interaction with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60ba35be83bbf2adf4b2e64a47e18e8
https://doi.org/10.1016/j.jprot.2009.12.002
https://doi.org/10.1016/j.jprot.2009.12.002
Autor:
Yan Luo, Mathias Dreger, Michael Sefkow, Hubert Köster, Christian Blex, Mirko Glinski, Olivia Baessler
Publikováno v:
Molecular & Cellular Proteomics. 8:2843-2856
The profiling of subproteomes from complex mixtures on the basis of small molecule interactions shared by members of protein families or small molecule interaction domains present in a subset of proteins is an increasingly important approach in funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77b3d5926b3875df923989ce3b6c7ac4
https://doi.org/10.1074/mcp.m900110-mcp200
https://doi.org/10.1074/mcp.m900110-mcp200
Publikováno v:
Phytochemistry. 70:1309-1314
Di-nor-benzofuran neolignan aldehydes, Delta(7)-3,4-methylenedioxy-3'-methoxy-8',9'-dinor-4',7-epoxy-8,3'-neolignan-7'-aldehyde (ocophyllal A) 1, Delta(7)-3,4,5,3'-tetramethoxy-8',9'-dinor-4',7-epoxy-8,3'-neolignan-7'-aldehyde (ocophyllal B) 2, and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9701628444477f412cc447c691401a71
https://doi.org/10.1016/j.phytochem.2009.07.010
https://doi.org/10.1016/j.phytochem.2009.07.010