Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael Sean Pepper"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions
Externí odkaz:
https://doaj.org/article/413f6605a3ab484d8ddeb20c08dcbe3c
Autor:
Rosemary Ida Kabahuma, Wolf‐Dieter Schubert, Christiaan Labuschagne, Denise Yan, Michael Sean Pepper, Xue‐Zhong Liu
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract Background DFNB28, a recessively inherited nonsyndromic form of deafness in humans, is caused by mutations in the TRIOBP gene (MIM #609761) on chromosome 22q13. Its protein TRIOBP helps to tightly bundle F‐actin filaments, forming a rootle
Externí odkaz:
https://doaj.org/article/3432dc163ba648008a39bd6d1476a3f6
Autor:
Victoria Damerell, Melvin Anyasi Ambele, Shanel Salisbury, Alexis Neumann-Mufweba, Chrisna Durandt, Michael Sean Pepper, Sharon Prince
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the molecular mechanisms underpinning the transformation of mesenchymal stromal/stem cells (MSC
Externí odkaz:
https://doaj.org/article/51f1f7ec9f51405ba43eb6e73221ec88
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which causes local tissue damage a
Externí odkaz:
https://doaj.org/article/29809ccfd9c34070b1fa7ff84e476c2a
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Tumours are characterized by a state of chronic inflammation and are regarded as wounds that never heal. Mesenchymal stromal/stem cells (MSCs) are being considered as a possible treatment option. While MSCs can regulate the immune system, migrate to
Externí odkaz:
https://doaj.org/article/723b92eaaaf94ce6a4f0e55a144f66ad
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101186- (2021)
Bioprinting is a rapidly expanding technology with the ability to fabricate in vitro three-dimensional (3D) tissues in a layer-by-layer manner to ultimately produce a living tissue which physiologically resembles native in vivo tissue functionality.
Externí odkaz:
https://doaj.org/article/90a85b6b150f42e0a6275695b6d2a434
Publikováno v:
Stem Cells Translational Medicine, Vol 7, Iss 9, Pp 643-650 (2018)
Abstract Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non‐malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is
Externí odkaz:
https://doaj.org/article/ff3ccae38ee24659b528428ba3b48491
Autor:
Victoria Nembaware, African Genomic Medicine Training Initiative, Nicola Mulder, Omar Abidi, MB Akanle, Stuart Alvaro Ali, Cliff Asher Aliga, Paballo Chauke, Minnet Cotzee, Collet Dandara, Faisal M. Fadlelmola, Michael B. Fawale, Pedro L. Fernandes, Karen Ghansah, Zainab Abimbola Kashim, Samar Kamal Kassim, Morenikeji A. Komolafe, Guida Landouré, Cordelia Leisegang, Ebony B Madden, Kuda Majada, Malebo Malope, Mamadou Kaba, Keofentse Mathuba, Alice Matimba, George Mochamah, Sarah L Morgan, Nash Oyekanmi, Nchangwi S Munung, Temitope Esther Owoeye, Michael Sean Pepper, Lunelle Pienaar, Elize Pietersen, Fouzia Radouani, Raj S Ramesar, Michelle Skelton, Sununguko Wata Mpoloka, Wayengerera Misaki, Ambroise Wonkam, Adetunji Samuel Adesina, Tina-Marié Wessels
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The potential of genomic medicine in improving the quality of healthcare both at population and individual-level is well-recognized globally. However, successful adoption of genetic and genomic evidence into clinical practice depends on training the
Externí odkaz:
https://doaj.org/article/8214b855680044f8ab8ea8c88c48041e
Autor:
Carlo Stephan Jackson, Chrisna Durandt, Ilse Janse van Rensburg, Vincent Praloran, Philippe Brunet de la Grange, Michael Sean Pepper
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 124-131 (2017)
Culture conditions used for the expansion of hematopoietic stem and progenitor cells (HSCs and HPCs, collectively HSPCs) should ideally favor the self renewal of long-term HSCs. At 20% O2, the synthesis of HIF-1α is balanced by its hydroxylation and
Externí odkaz:
https://doaj.org/article/f2adcef4b1d64c1a9bce91d593a0c484
Autor:
Dina Christina Janse van Rensburg, Catharina Cornelia Grant, Audrey Jansen van Rensburg, Roelf Petrus Gerhardus Botha, Paola Silvia Wood, Kim Nolte, Lizelle Fletcher, Peet Jacobus du Toit, Michael Sean Pepper, Pieter Ernst Kruger
Publikováno v:
Health SA Gesondheid: Journal of Interdisciplinary Health Sciences, Vol 21, Iss C, Pp 431-436 (2016)
Background: The FitTrack Index is a web-based programme developed in South Africa and widely used by athletes to indicate their fitness. A need exists for a self-managed, non-invasive tool to evaluate and categorise health-related fitness in differen
Externí odkaz:
https://doaj.org/article/dee3942c47d94c4a9a45b364576559e5