Zobrazeno 1 - 10 of 94 pro vyhledávání: '"Michael Seagar"'
1
Akademický článek
The downregulation of Kv1 channels in Lgi1−/− mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels
Autor: Jorge Ramirez-Franco, Kévin Debreux, Marion Sangiardi, Maya Belghazi, Yujin Kim, Suk-Ho Lee, Christian Lévêque, Michael Seagar, Oussama El Far
Publikováno v: Neurobiology of Disease, Vol 196, Iss , Pp 106513- (2024)
In animal models of LGI1-dependent autosomal dominant lateral temporal lobe epilepsy, Kv1 channels are downregulated, suggesting their crucial involvement in epileptogenesis. The molecular basis of Kv1 channel-downregulation in LGI1 knock-out mice ha
Externí odkaz: https://doaj.org/article/2e7ee02f8fec4a0aa115a578527a6516
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2
Akademický článek
A Role for the V0 Sector of the V-ATPase in Neuroexocytosis: Exogenous V0d Blocks Complexin and SNARE Interactions with V0c
Autor: Christian Lévêque, Yves Maulet, Qili Wang, Marion Rame, Léa Rodriguez, Sumiko Mochida, Marion Sangiardi, Fahamoe Youssouf, Cécile Iborra, Michael Seagar, Nicolas Vitale, Oussama El Far
Publikováno v: Cells, Vol 12, Iss 5, p 750 (2023)
V-ATPase is an important factor in synaptic vesicle acidification and is implicated in synaptic transmission. Rotation in the extra-membranous V1 sector drives proton transfer through the membrane-embedded multi-subunit V0 sector of the V-ATPase. Int
Externí odkaz: https://doaj.org/article/59f893d975e14efca870c5732bb32957
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3
Akademický článek
Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor
Autor: Richard Desplantes, Christian Lévêque, Benjamin Muller, Manuela Lotierzo, Géraldine Ferracci, Michel Popoff, Michael Seagar, Robert Mamoun, Oussama El Far
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The development of simple molecular assays with membrane protein receptors in a native conformation still represents a challenging task. Exosomes are extracellular vesicles which, due to their stability and small size, are suited for analysi
Externí odkaz: https://doaj.org/article/9910d540c8b94f5dbe7a7370c996bd77
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4
Akademický článek
Phoneutria nigriventer ω-Phonetoxin IIA: A new tool for anti-calcium channel autoantibody assays in Lambert–Eaton myasthenic syndrome
Autor: Nicole Martin-Moutot, Luc de Haro, Raquel Gouvea Dos Santos, Yasuo Mori, Michael Seagar
Publikováno v: Neurobiology of Disease, Vol 22, Iss 1, Pp 57-63 (2006)
Lambert–Eaton myasthenic syndrome (LEMS) is a neurological autoimmune disease in which downregulation of voltage-gated calcium channels (VGCCs) leads to reduced acetylcholine release from motoneuron terminals. 70% of cases are paraneoplastic and ra
Externí odkaz: https://doaj.org/article/b521c5240004407284afab0aa8d6753e
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5
Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex
Autor: Jorge Ramirez-Franco, Fodil Azzaz, Marion Sangiardi, Géraldine Ferracci, Fahamoe Youssouf, Michel Robert Popoff, Michael Seagar, Christian Lévêque, Jacques Fantini, Oussama El Far
Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2022, 79 (9), pp.496. ⟨10.1007/s00018-022-04527-4⟩
International audience; Botulinum neurotoxin serotype B (BoNT/B) uses two separate protein and polysialoglycolipid-binding pockets to interact with synaptotagmin 1/2 and gangliosides. However, an integrated model of BoNT/B bound to its neuronal recep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d2f4bb309d656f914aa9f1bcac9eb7
https://pubmed.ncbi.nlm.nih.gov/36006520
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6
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
Autor: Jorge Ramirez-Franco, Kévin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian Lévêque, Claire Debarnot, Pascale Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh R Irani, Oussama El Far
Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, 2022, pp.awac218. ⟨10.1093/brain/awac218⟩
Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cellular and su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47e29bfb73faf39171eae8c48c1bcf2
https://pubmed.ncbi.nlm.nih.gov/35727946
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8
The protein-binding pocket of Botulinum neurotoxin B accommodates a preassembled synaptotagmin / ganglioside complex
Autor: Jacques Fantini, Fodil Azzaz, Michel R. Popoff, Michael Seagar, Marion Sangiardi, Christian Lévêque, Oussama El Far, Jorge Ramírez-Franco, Fahamoe Youssouf, G eacuteraldine Ferracci
Botulinum neurotoxin serotype B (BoNT/B) uses two separate protein and polysialoglycolipid-binding pockets to interact with synaptotagmin 1/2 and gangliosides. However, an integrated model of BoNT/B bound to its neuronal receptors in a native membran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::882c89f0524778507e226a009bc715c1
https://doi.org/10.1101/2021.10.18.464377
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9
Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification
Autor: Dominique Debanne, Oussama El Far, Yves Maulet, Sylvain Rama, Christian Lévêque, Fahamoe Youssouf, Michael Seagar, Norah Boumedine-Guignon, Marion Sangiardi, Maya Belghazi
Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2019, 56 (5), pp.3591-3602. ⟨10.1007/s12035-018-1324-1⟩
Molecular Neurobiology, 2019, 56 (5), pp.3591-3602. ⟨10.1007/s12035-018-1324-1⟩
International audience; Synaptic vesicle proton V-ATPase is an essential component in synaptic vesicle function. Active acidification of synaptic vesicles, triggered by the V-ATPase, is necessary for neurotransmitter storage. Independently from its p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb57ad10c24eee92d5311388dfdb3fd1
https://www.hal.inserm.fr/inserm-01878772/document
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10
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
Autor: Kévin Debreux, Géraldine Ferracci, Marion Sangiardi, Richard Desplantes, Jacques Fantini, Christian Lévêque, Marie-Pierre Blanchard, Fahamoe Youssouf, Cécile Iborra, Oussama El Far, Jorge Ramírez-Franco, Yves Maulet, Alessandra Flores, Michel R. Popoff, Florian Wernert, Michael Seagar
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (36), pp.18098-18108. ⟨10.1073/PNAS.1908051116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (36), pp.18098-18108. ⟨10.1073/PNAS.1908051116⟩
International audience; Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor components: a polysialoganglioside, predominantly GT1b, and synaptotagmin 1/2. It is widely thought that BoNT/B initially binds to GT1b t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ece8a080cc84fd202aa04b00b7394c
https://www.hal.inserm.fr/inserm-02274412/document
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