Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael Schwenkert"'
Autor:
Sabrina Kneissl, Qi Zhou, Michael Schwenkert, François-Loic Cosset, Els Verhoeyen, Christian J Buchholz
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79047 (2013)
B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vector
Externí odkaz:
https://doaj.org/article/8b9b2f53c7cd4bbd92ad2213161fa91e
Autor:
Michael Schwenkert, Gerold Schuler, Andreas Hombach, Hinrich Abken, Jan Dörrie, Beatrice Schuler-Thurner, Christian Krug, Alexander Paulus, Patrick Schmidt, Nicole Hoffmann, Georg H. Fey, Niels Schaft, Katrin Birkholz
Publikováno v:
Cancer Immunology, Immunotherapy. 64:1623-1635
Chimeric antigen receptor (CAR)-modified T cells emerged as effective tools in the immunotherapy of cancer but can produce severe on-target off-tissue toxicities. This risk can conceivably be overcome, at least partially, by transient transfection. T
Autor:
Joerg Bruenke, Matthias Peipp, Bernhard Stockmeyer, Christoph Stein, Georg H. Fey, Kristin Mentz, Heike Horner, Joerg Schubert, Michael Schwenkert, Karin Barbin, Christian Kellner
Publikováno v:
Cancer Letters. 303:128-139
Bispecific scFv antibody-derivatives (bsscFvs) recruiting natural killer (NK) cells for the lysis of malignant cells have therapeutic potential. However, a bsscFv specific for the B-lymphoid tumor antigen CD19 and the trigger molecule CD16 on NK cell
Autor:
Michael Schwenkert, Christoph Stein, Georg H. Fey, Andreas Mackensen, Fuat Oduncu, Markus Kügler, Kristin Mentz, Bernhard Stockmeyer, Ingo Schubert, Christian Kellner, Heiko Singer, Domenica Saul
Publikováno v:
British Journal of Haematology. 150:574-586
Two trivalent constructs consisting of single-chain Fv antibody fragments (scFvs) specific for the interleukin-3 receptor alpha chain (CD123), CD33 and the Fcgamma-receptor III (CD16) were designed and characterized for the elimination of acute myelo
Autor:
Christian Kellner, Julia Stieglmaier, Georg H. Fey, Kristin Mentz, Peter Lang, Michael Schwenkert, Michael Schwemmlein, Matthias Peipp, Bernhard Stockmeyer, Fuat Oduncu, Joerg Bruenke, Heiko Singer
Publikováno v:
Journal of Immunotherapy. 31:871-884
A novel bispecific antibody-derived recombinant protein targeting leukemias and lymphomas was designed, a single-chain Fv triple body (sctb) consisting of 1 polypeptide chain with 3 scFvs connected in tandem. The distal scFvs were specific for the tu
Autor:
Michael Schwenkert, Matthias Peipp, Jan Dörrie, Katrin Birkholz, Christian Kellner, Dirk M. Nettelbeck, Niels Schaft, Georg H. Fey, Beatrice Schuler-Thurner, Eckhart Kämpgen, Markus Kügler, Soldano Ferrone, Michael Schwemmlein
Publikováno v:
Melanoma Research. 18:73-84
A recombinant immunotoxin was constructed by fusing a single chain fragment variable antibody fragment, specific for the melanoma-associated chondroitin sulfate proteoglycan (MCSP), to a truncated variant of Pseudomonas exotoxin A (ETA'), carrying a
Autor:
Manal, Amoury, Radoslav, Mladenov, Thomas, Nachreiner, Anh-Tuan, Pham, Dmitrij, Hristodorov, Stefano, Di Fiore, Wijnand, Helfrich, Alessa, Pardo, Georg, Fey, Michael, Schwenkert, Theophilus, Thepen, Fabian, Kiessling, Ahmad F, Hussain, Rainer, Fischer, Katharina, Kolberg, Stefan, Barth
Publikováno v:
International journal of cancer. 139(4)
Chondroitin sulfate proteoglycan 4 (CSPG4) has been identified as a highly promising target antigen for immunotherapy of triple-negative breast cancer (TNBC). TNBC represents a highly aggressive heterogeneous group of tumors lacking expression of est
Autor:
Ingo Schubert, Markus Kügler, Michael Schwenkert, Georg H. Fey, Andreas Mackensen, Fuat Oduncu, Domenica Saul, Christoph Stein, Bernhard Stockmeyer, Christian Berens, Christian Kellner
To test the hypothesis that dual-targeting confers the novel ability of selective binding to antigen double-positive over antigen single-positive cells, a single-chain triplebody (sctb), HLA-ds16-hu19, was produced and characterized. The molecule car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9880ce136b76dd521077c03737ac9bf9
https://europepmc.org/articles/PMC3338940/
https://europepmc.org/articles/PMC3338940/
Autor:
Ingo Schubert, Andreas Mackensen, Michael Schwenkert, Domenica Saul, Christoph Stein, Kristin Mentz, Wolfgang Hillen, Georg H. Fey, Christian Kellner, Bernhard Stockmeyer, Heiko Singer, Markus Kügler
A single-chain triplebody (sctb) 33-ds16-ds19 comprising two distal single-chain Fv fragments (scFvs) specific for the lymphoid antigen CD19 and the myeloid antigen CD33 flanking a central scFv specific for CD16, which is the low affinity Fc-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1829224576db9d26b73db6669177fb5e
https://europepmc.org/articles/PMC3038008/
https://europepmc.org/articles/PMC3038008/
Autor:
Markus, Kügler, Christoph, Stein, Christian, Kellner, Kristin, Mentz, Domenica, Saul, Michael, Schwenkert, Ingo, Schubert, Heiko, Singer, Fuat, Oduncu, Bernhard, Stockmeyer, Andreas, Mackensen, Georg H, Fey
Publikováno v:
British journal of haematology. 150(5)
Two trivalent constructs consisting of single-chain Fv antibody fragments (scFvs) specific for the interleukin-3 receptor alpha chain (CD123), CD33 and the Fcgamma-receptor III (CD16) were designed and characterized for the elimination of acute myelo