Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael Schuleit"'
Autor:
Benjamin R. Freedman, Andreas Kuttler, Nicolau Beckmann, Sungmin Nam, Daniel Kent, Michael Schuleit, Farshad Ramazani, Nathalie Accart, Anna Rock, Jianyu Li, Markus Kurz, Andreas Fisch, Thomas Ullrich, Michael W. Hast, Yann Tinguely, Eckhard Weber, David J. Mooney
Publikováno v:
Nature Biomedical Engineering. 6:1167-1179
Hydrogels that provide mechanical support and sustainably release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate
Autor:
Samaneh Pazesh, Michael Schuleit, Anna Millqvist-Fureby, Göran Alderborn, Niklas Nordgren, Maria Badal Tejedor, Mark W. Rutland
Publikováno v:
International Journal of Pharmaceutics. 537:140-147
Preprocessing of pharmaceutical powders is a common procedure to condition the materials for a better manufacturing performance. However, such operations may induce undesired material properties modifications when conditioning particle size through m
Autor:
Niklas Nordgren, Samaneh Pazesh, Göran Alderborn, Michael Schuleit, Mark W. Rutland, Maria Badal Tejedor, Anna Millqvist-Fureby
Publikováno v:
Langmuir. 33:920-926
The nature of the surfaces of particles of pharmaceutical ingredients, food powders, and polymers is a determining factor for their performance in for example tableting, powder handling, or mixing. Changes on the surface structure of the material wil
Autor:
Sabine Guth-Gundel, Benjamin R. Freedman, Michael Schuleit, Andreas Kuttler, Bruno Tigani, Mara Fornaro, Michaela Kneissel, Alexander G. Stafford, Jianyu Li, Anne Basler, David J. Mooney, Arno Doelemeyer, Nathalie Accart, Kuno Wuersch, Eckhard Weber, Christine Halleux
Publikováno v:
Advanced healthcare materials. 7(9)
Hydrogels are under active development for controlled drug delivery, but their clinical translation has been limited by low drug loading capacity, deficiencies in mechanical toughness and storage stability, and poor control over the drug release that
Autor:
Maria Badal Tejedor, Michael Schuleit, Anna Millqvist-Fureby, Niklas Nordgren, Mark W. Rutland
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 33(46)
Adhesion of the powders to the punches is a common issue during tableting. This phenomenon is known as sticking and affects the quality of the manufactured tablets. Defective tablets increase the cost of the manufacturing process. Thus, the ability t
Autor:
Baskim Ajdini, Lorenz Meinel, Pascale Holzerny, Michael Schuleit, Wolf Heusermann, Michael Keller, Katharina Bruno
Publikováno v:
Journal of Controlled Release. 157:297-304
Chitosans are naturally occurring polymers widely used in life science to mediate intracellular uptake of nucleic acids such as siRNA. Four chitosans of fungal origin (Agaricus bisporus; molecular weights MW = 44, 63, 93 and 143 kDa) were used in thi
Publikováno v:
Molecular Pharmaceutics. 8:1247-1256
Despite the advantages offered by solid dispersions, the marketed products based on this technology are few. The most frequent concern is the stability of the amorphous drug. The state of the drug in solid dispersions is, in general, poorly character
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 76:311-319
Solid dispersion tablets prepared by either spray drying or rotoevaporation and exhibiting different grain and pore sizes were investigated under the process of hydration-swelling-gelation. (2)H and (1)H NMR microimaging experiments were used to sele
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 70:478-485
Solid dispersions are promising drug delivery forms which offer the possibility to disperse a hydrophobic drug in a hydrophilic matrix and thereby improve the dissolution behavior and the bioavailability of the drug. One important aspect and a prereq
Publikováno v:
International Journal of Pharmaceutics. 309:157-162
NMR cryoporometry is a unique method permitting the investigation of pores in the microporous and mesoporous regimes for samples in aqueous environments. Here, we apply the technique to porous biodegradable polymer microparticles designed as devices