Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael Schrag"'
Autor:
Dan G. Duda, Andrew X. Zhu, Devalingam Mahalingam, Rebecca Miksad, Alok A. Khorana, Thomas A. Abrams, Gulam A. Manji, Anthony B. El-Khoueiry, Stacey Stein, Jennifer R. Eads, Michael H. Kagey, Michael Schrag, Cynthia Sirard, Lipika Goyal
Purpose:Dickkopf-1 (DKK1) modulates Wnt signaling, promoting tumor growth, metastasis, and immunosuppression. High DKK1 expression has been detected in various tumor types—including biliary tract cancer (BTC)—and is associated with poor prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acc2e0adf4f209458f9bd53a8d231f5
https://doi.org/10.1158/1078-0432.c.6529550.v1
https://doi.org/10.1158/1078-0432.c.6529550.v1
Autor:
Dan G. Duda, Andrew X. Zhu, Devalingam Mahalingam, Rebecca Miksad, Alok A. Khorana, Thomas A. Abrams, Gulam A. Manji, Anthony B. El-Khoueiry, Stacey Stein, Jennifer R. Eads, Michael H. Kagey, Michael Schrag, Cynthia Sirard, Lipika Goyal
Text and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189c3a90ac5930ea842b4b08064234ff
https://doi.org/10.1158/1078-0432.22476995.v1
https://doi.org/10.1158/1078-0432.22476995.v1
Autor:
Michael H. Kagey, Anthony B. El-Khoueiry, Lipika Goyal, Devalingam Mahalingam, Michael Schrag, Gulam Abbas Manji, Stacey Stein, Andrew X. Zhu, Alok A. Khorana, Cynthia A. Sirard, Dan G. Duda, Rebecca A. Miksad, Jennifer R. Eads, Thomas A. Abrams
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(23)
Purpose: Dickkopf-1 (DKK1) modulates Wnt signaling, promoting tumor growth, metastasis, and immunosuppression. High DKK1 expression has been detected in various tumor types—including biliary tract cancer (BTC)—and is associated with poor prognosi
Autor:
Min Wong, Yang Xu, Scot Middleton, Matthew R. Lee, Anu Gore, Mike Fiorino, Alex Pickrell, Kristine M. Muller, Andrea Itano, Mike Frohn, Heather A. Arnett, Janet Buys, Michelle Horner, Dalia Rivenzon-Segal, Jennifer E. Golden, Victor J. Cee, Hugo M. Vargas, Roland Burli, Susana C. Neira, Michael Schrag, Han Xu, Brian A. Lanman, Michele McElvain, Xuxia Zhang, Jerry Siu
Publikováno v:
ACS Medicinal Chemistry Letters. 2:107-112
The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo-[5,4-b]pyridin-2-yl)benzyl)azetidine-3-ca
Autor:
Hugo M. Vargas, Yang Xu, Jerry Siu, Janet Buys, Michelle Horner, Jian Lin, Ashis Saha, Han Xu, Michele McElvain, Anurag Sharadendu, Scot Middleton, Roland Burli, Yael Marantz, Dalia Segal, Kevin Salyers, Mercedes Lobera, Dilara Mccauley, Srinivas Chereku, Xiang Yu, Nili Schutz, Michael Schrag
Publikováno v:
ACS Medicinal Chemistry Letters. 2:97-101
We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P1 agonist with >1000× selectivity over S1
Autor:
Virginia Berry, Alexander M. Long, Tom DeMelfi, Nicholas Doerr, Philip Roveto, Yohannes Teffera, Loren Berry, Anthony Polverino, Danlin Chen, Juan Estrada, George Borg, Roger Zanon, Charlie Starnes, James Bready, Shawn Harriman, Kelly Regal, Michael Schrag, Jean-Christophe Harmange, David Bauer, Russell Graceffa, Daniel S. La, Vinod F. Patel, Sesha Neervannan, Matthew Weiss, Angela Coxon, Andrew Tasker, Douglas A. Whittington, Michele Potashman, Julie Flynn, Stephen Kaufman, Deborah Choquette
Publikováno v:
Journal of Medicinal Chemistry. 51:1668-1680
We have previously shown N-arylnaphthamides can be potent inhibitors of vascular endothelial growth factor receptors (VEGFRs). N-Alkyl and N-unsubstituted naphthamides were prepared and found to yield nanomolar inhibitors of VEGFR-2 (KDR) with an imp
Publikováno v:
Archives of Biochemistry and Biophysics. 438:21-28
The metabolism of pyrene to hydroxypyrene by CYP3A4 was investigated to determine the effect of cytochrome b5 (b5) on turnover kinetics. In the absence of b5, formation of hydroxypyrene in in vitro incubations showed a biphasic substrate-velocity cur
Autor:
Roland Burli, Matthew H. Plant, Randall W. Hungate, Roxanne Kunz, Douglas A. Whittington, Yang Xu, Shannon Rumfelt, Gordon Ng, Violeta Yu, Michael Schrag, Ning Chen, Yen Nguyen, Yanyan Tudor, Andrew Tasker, Kristin Meagher, Essa Hu, Dawei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5115-5117
Deregulation of the receptor tyrosine kinase c-Kit is associated with an increasing number of human diseases, including certain cancers and mast cell diseases. Interference of c-Kit signaling with multi-kinase inhibitors has been shown clinically to
Autor:
Mohamoud M. Abdi, Nabil Hussain Al-Humadi, Mayssa Attar, Theodore J. Baird, Jeff Behrens, Nathan Boersen, Jacqueline A. Brassard, Melissa J. Beck, Jennifer G. Brown, Edward W. Carney, Ting-Tung A. Chang, Mingli Chen, Dorothy B. Colagiovanni, John B. Colerangle, Roger Collins, Rebecca Dabora, Jill A. Dalton, Kevin H. Denny, Rodney R. Dietert, Forbes P. Donald, J. Neil Duncan, John T. Farmer, Ali S. Faqi, Stephen Frantz, Les Freshwater, Tobias C. Fuchs, David V. Gauvin, Martin David Green, Lining Guo, Scott P. Henry, Philip G. Hewitt, Alan Hoberman, Ho-Wah Hui, Julia Y. Hui, Colleen Johnson, John W. Kille, Andrea S. Kim, Tae-Won Kim, Neil Kirby, Douglas Kornbrust, Douglas B. Learn, Thomas Lee, Elise Lewis, Steven Matsumoto, David L. McCormick, Kathleen B. Meyer-Tamaki, Odete R. Mendes, Michael V. Milburn, Igor Mikaelian, LaRonda L. Morford, John Nicolette, Paul Nugent, Hyesun H. Oh, Lekan Oyejide, Meg Ramos, Kelly A. Regal, David Rehagen, John Cody Resendez, John A. Ryals, Christopher P. Sambuco, Michael Schrag, David G. Serota, Raja Settivari, Richard Slauter, Christopher W. Stewart, Donald Stump, Sekhar Surapaneni, Michael Templin, Bjorn A. Thorsrud, Germaine L. Truisi, Chang Vangyi, Tom Vidmar, Jim Vrbanac, Qingli Wang, Zheng J. Wang, Lawrence O. Whitely, James S. Yan, Malcolm J. York, Husam S. Younis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa595349a72c0097cbac46cf9de6668
https://doi.org/10.1016/b978-0-12-387815-1.10037-1
https://doi.org/10.1016/b978-0-12-387815-1.10037-1
Autor:
Kelly Regal, Michael Schrag
The evaluation of a compound's pharmacokinetics (PK) and toxicokinetics (TK) is one critical component in understanding how a drug works in vivo. In the 1990s, one of the primary reasons for the failure of early clinical studies was poor or inadequat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a82b2ba96cb4ed396b26fe6d123867
https://doi.org/10.1016/b978-0-12-387815-1.00003-4
https://doi.org/10.1016/b978-0-12-387815-1.00003-4