Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael Schnall-Levin"'
Autor:
Grace X. Y. Zheng, Jessica M. Terry, Phillip Belgrader, Paul Ryvkin, Zachary W. Bent, Ryan Wilson, Solongo B. Ziraldo, Tobias D. Wheeler, Geoff P. McDermott, Junjie Zhu, Mark T. Gregory, Joe Shuga, Luz Montesclaros, Jason G. Underwood, Donald A. Masquelier, Stefanie Y. Nishimura, Michael Schnall-Levin, Paul W. Wyatt, Christopher M. Hindson, Rajiv Bharadwaj, Alexander Wong, Kevin D. Ness, Lan W. Beppu, H. Joachim Deeg, Christopher McFarland, Keith R. Loeb, William J. Valente, Nolan G. Ericson, Emily A. Stevens, Jerald P. Radich, Tarjei S. Mikkelsen, Benjamin J. Hindson, Jason H. Bielas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Single-cell gene expression analysis is challenging. This work describes a new droplet-based single cell RNA-seq platform capable of processing tens of thousands of cells across 8 independent samples in minutes, and demonstrates cellular subtypes and
Externí odkaz:
https://doaj.org/article/9c33171e807745c7908a1e1e9a3712e3
Autor:
Assaf Rotem, Oren Ram, Noam Shoresh, Ralph A Sperling, Michael Schnall-Levin, Huidan Zhang, Anindita Basu, Bradley E Bernstein, David A Weitz
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0116328 (2015)
The importance of single-cell level data is increasingly appreciated, and significant advances in this direction have been made in recent years. Common to these technologies is the need to physically segregate individual cells into containers, such a
Externí odkaz:
https://doaj.org/article/d8770f8d4dff4c1586d2ffb8958f9d41
Autor:
Clemens Bergwitz, Mark J Wee, Sumi Sinha, Joanne Huang, Charles DeRobertis, Lawrence B Mensah, Jonathan Cohen, Adam Friedman, Meghana Kulkarni, Yanhui Hu, Arunachalam Vinayagam, Michael Schnall-Levin, Bonnie Berger, Lizabeth A Perkins, Stephanie E Mohr, Norbert Perrimon
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e56753 (2013)
Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans. However, the mechanisms underlying homeostatic control of extracellular phosphate levels and cel
Externí odkaz:
https://doaj.org/article/e7e53f918c6d4218808ddad292f72774
Autor:
Sauzade M, Joe Shuga, Hanlee P. Ji, George A. Poultsides, Hepler L, Yang W, Michael Schnall-Levin, Yifeng Yin, Kumar, Tobias Daniel Wheeler, Susan M. Grimes, Bill Kengli Lin, Sullivan-Bibee K, Claudia Catalanotti, Stafford D, Billy T. Lau, Susanna Jett, Makarewicz Aj, Song M, Rajiv Bharadwaj, Džakula Ž, Zachary Bent, Sawhney Ss, Anuja Sathe, Andrew D. Price, Jon Sorenson, Jia-Yun Chen, Noemi Andor, Carlos Suárez, Matthew Kubit, Shamoni Maheshwari, Weinstein A, DeMare L, Rahimi M, Kamila Belhocine
Sequencing the genomes of individual cancer cells provides the highest resolution of intratumoral heterogeneity. To enable high throughput single cell DNA-Seq across thousands of individual cells per sample, we developed a droplet-based, automated pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cc1b57d7322984b5bcef5f31ec0431
Autor:
Pui-Yan Kwok, Kristina Giorda, Alex Hastie, Patrick Marks, Jeffrey D. Wall, Jessica Lam, Catherine Chu, Joyce Lee, Michal Levy-Sakin, Yulia Mostovoy, Ernest T. Lam, Chin Lin, Michael Schnall-Levin, Stephen A. Schlebusch, Han Cao, Željko Džakula
Publikováno v:
Nature methods
Despite tremendous progress in genome sequencing, the basic goal of producing a phased (haplotype-resolved) genome sequence with end-to-end contiguity for each chromosome at reasonable cost and effort is still unrealized. In this study, we describe a
Autor:
Kenneth Paigen, John Wright, Rosie McEachan, Eamonn Sheridan, Dan Mason, Yali Xue, Laura Southgate, Richard C. Trembath, Konrad J. Karczewski, Anne H. O’Donnell-Luria, Monkol Lek, Kristina Giorda, David A. van Heel, Srikanth Bellary, Chris Tyler-Smith, Mark G. Thomas, Louise Tee, Vagheesh M. Narasimhan, Michael Schnall-Levin, Shane A. McCarthy, Eamonn R. Maher, Jia Zhilong, Hajrah A. Khawaja, Harry Hemingway, Christopher M. Bates, Christopher L. Baker, Ann M. Kelly, Petko M. Petkov, Daniel G. MacArthur, Nicholas A. Bockett, Constantinos A. Parisinos, Anthony H. Barnett, Karen A. Hunt, Richard Durbin, Chris Griffiths, Michael R. Barnes
Publikováno v:
Science. 352:474-477
Rare gene knockouts in adult humans On average, most people's genomes contain approximately 100 completely nonfunctional genes. These loss-of-function (LOF) mutations tend to be rare and/or occur only as a single copy within individuals. Narasimhan e
Autor:
Francesca Meschi, Indira Wu, David Stafford, Andrew Wei Xu, Heather Ordonez, Jill Herschleb, Esty Holt, Tony Makarewicz, Shazia Mahamdallie, Elise Ruark, Josh Delaney, Adam Lowe, Pranav Patel, Stephen R. Williams, Christopher Hindson, Sarah T. Garcia, Nikka Keivanfar, Alvaro Martinez Barrio, Ian T. Fiddes, Keith Bjornson, Sheila Seal, Preyas Shah, Ariel Royall, Claudia Catalanotti, Patrick Marks, Jamie L. Marshall, Daniel G. MacArthur, Rajiv Bharadwaj, Nazneen Rahman, Bill Kengli Lin, Sofia Kyriazopoulou-Panagiotopoulou, Susanna Jett, Adrian Fehr, Haynes Heaton, Christopher J. O'Keefe, Deanna M. Church, Andrew D. Price, Shamoni Maheshwari, Brendan Galvin, Cassandra B. Jabara, Kamila Belhocine, Monkol Lek, Michael Schnall-Levin, Jorge Bernate
Publikováno v:
Genome research. 29(4)
Large-scale population analyses coupled with advances in technology have demonstrated that the human genome is more diverse than originally thought. To date, this diversity has largely been uncovered using short-read whole-genome sequencing. However,
Autor:
Patrick Marks, Sarah Garcia, Alvaro Martinez Barrio, Kamila Belhocine, Jorge Bernate, Rajiv Bharadwaj, Keith Bjornson, Claudia Catalanotti, Josh Delaney, Adrian Fehr, Ian T. Fiddes, Brendan Galvin, Haynes Heaton, Jill Herschleb, Christopher Hindson, Esty Holt, Cassandra B. Jabara, Susanna Jett, Nikka Keivanfar, Sofia Kyriazopoulou-Panagiotopoulou, Monkol Lek, Bill Lin, Adam Lowe, Shazia Mahamdallie, Shamoni Maheshwari, Tony Makarewicz, Jamie Marshall, Francesca Meschi, Chris O’keefe, Heather Ordonez, Pranav Patel, Andrew Price, Ariel Royall, Elise Ruark, Sheila Seal, Michael Schnall-Levin, Preyas Shah, Stephen Williams, Indira Wu, Andrew Wei Xu, Nazneen Rahman, Daniel MacArthur, Deanna M. Church
Large-scale population based analyses coupled with advances in technology have demonstrated that the human genome is more diverse than originally thought. To date, this diversity has largely been uncovered using short read whole genome sequencing. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d0453a799d81bfca88092832de0b65
https://doi.org/10.1101/230946
https://doi.org/10.1101/230946
Autor:
Rajiv Bharadwaj, Paul Wyatt, Joe Shuga, Donald A. Masquelier, Tarjei S. Mikkelsen, Mark T. Gregory, Junjie Zhu, Jerald P. Radich, Emily A. Stevens, Solongo B. Ziraldo, Christopher McFarland, Luz Montesclaros, Nolan G. Ericson, Alexander Wong, William J. Valente, Benjamin J. Hindson, Tobias Daniel Wheeler, Jason G. Underwood, H. Joachim Deeg, Jessica M. Terry, Kevin D. Ness, Phillip Belgrader, Stefanie Y. Nishimura, Geoffrey P. McDermott, Michael Schnall-Levin, Jason H. Bielas, Zachary Bent, Lan Beppu, Paul Ryvkin, Christopher Hindson, Grace X.Y. Zheng, Keith R. Loeb, Ryan Wilson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that enables 3′ mRNA counting of tens of thousands of single cells per sample. Cell encapsulation, o
Autor:
Nolan G. Ericson, Alexander Wong, Keith R. Loeb, Ryan Wilson, Zachary Bent, Emily A. Stevens, Tobias Daniel Wheeler, Rajiv Bharadwaj, H. Joachim Deeg, Jessica M. Terry, William J. Valente, Jason H. Bielas, Kevin D. Ness, Phillip Belgrader, Lan Beppu, Paul Ryvkin, Tarjei S. Mikkelsen, Geoffrey P. McDermott, Jerald P. Radich, Donald A. Masquelier, Solongo B. Ziraldo, Mark T. Gregory, Luz Montesclaros, Grace X.Y. Zheng, Christopher McFarland, Paul Wyatt, Christopher Hindson, Joe Shuga, Stefanie Y. Nishimura, Benjamin J. Hindson, Michael Schnall-Levin, Junjie Zhu
Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that enables 3′ mRNA counting of up to tens of thousands of single cells per sample. Cell encapsulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bb5ac0446559ec783467c8c0c59dd7
https://doi.org/10.1101/065912
https://doi.org/10.1101/065912