Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael Schleimer"'
Autor:
Dominique Klauer, Goetz Schlotterbeck, Mathias Wind, Arnaud Serafyn, Helge Grunwald, Michael Schleimer, Patrick Hargreaves, Klaus Gebhardt, Anne Schmitt-Hoffmann
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 85:138-144
A systematic comparison between two labeling approaches for the investigation of the in vitro metabolic pattern of pharmaceutical drugs was performed by examining the use of (i) radiolabeled drugs analyzed with LC-MS-offline radiodetection and (ii) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded91f32d734efc12c90731b0aeb4a20
https://doi.org/10.1016/j.jpba.2013.07.004
https://doi.org/10.1016/j.jpba.2013.07.004
A solid DMSO salvate of a compound of fornula (I) is described, which is a useful intemediate far preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4094::06b18b99cbe2eb2f3a7d5a3a63fb4021
http://hdl.handle.net/11585/767799
http://hdl.handle.net/11585/767799
Publikováno v:
Arzneimittelforschung. 52:593-599
Different experimental formulations based on aqueous and oily systems, water miscible solvents, and solid dispersions were investigated for their potential to increase the oral bioavailability (F) of two novel piperidine renin inhibitors (Ro-X1: (R)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca588bec548df30d528cde5383968e39
https://doi.org/10.1055/s-0031-1299936
https://doi.org/10.1055/s-0031-1299936
Autor:
Anne Schmitt-Hoffmann, Dominique Klauer, Mathias Wind, Patrick Roussel, Helge Grunwald, Michael Schleimer, Pascal Fullhardt, Jochen Spickermann, Klaus Illig, Claude Nuoffer, Klaus Gebhardt
Publikováno v:
Journal of Chromatography A. 1216:3946-3953
The in vitro metabolic profile of BAL30630, an antifungal piperazine propanol derivative, which inhibits the 1,3-beta- d -glucansynthase, was investigated by incubation with microsomes of several species and with rat hepatocytes. For the spotting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07571c51ae061a9fcc9ccee3c5a2170
https://doi.org/10.1016/j.chroma.2009.03.022
https://doi.org/10.1016/j.chroma.2009.03.022
Autor:
Jochen Spickermann, Klaus Gebhardt, Dominique Klauer, Massimiliano Donzelli, Mathias Wind, Anne Schmitt-Hoffmann, Rima Sturm-Haurany, Michael Schleimer, Pascal Fullhardt
Publikováno v:
Journal of Mass Spectrometry. 41:903-910
The metabolic profile of BAL4815, an antifungal azole drug, was determined using in vitro rat hepatocyte incubations and subsequent analysis by capillary LC-qTof-MS and MS/MS including accurate mass determination. For the detection of the metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2228c68141ee88f75d74d9ae47756242
https://doi.org/10.1002/jms.1049
https://doi.org/10.1002/jms.1049
Publikováno v:
Analytical Chemistry. 66:2893-2897
Immobilized chirasil-nickel (nickel(II) bis[3-(heptafluorobutanoyl)-(1R)-10-methylenecamphorate] chemically bonded to a poly(dimethylsiloxane)) was employed for the separation of enantiomers by capillary supercritical fluid chromatography and gas chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353c2a018e96b87bfdd15789a9f5ef50
https://doi.org/10.1021/ac00090a016
https://doi.org/10.1021/ac00090a016
Publikováno v:
Journal of Chromatography A. 679:23-34
The synthesis of two polysiloxane-based chiral stationary phases (CSPs) derived from a π-acidic N-(3.5-dinitrobenzoyl)-β-amino acid (JEM-1) and a π-basic N-(1-naphthyl)-leucine selector is described as is their systematical comparison with the cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302e66cd00bfb8814280a0a1eabc6432
https://doi.org/10.1016/0021-9673(94)80308-0
https://doi.org/10.1016/0021-9673(94)80308-0
Publikováno v:
Journal of Microcolumn Separations. 6:43-48
An immobilized chiral stationary phase, Chirasil-Dex, coated onto the inner surface of a 50 μm i.d. capillary and cyclodextrin derivatives added to the running buffer were simultaneously used for the study of enantiomer separations by capillary elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2139d72f5830fff08a4bcbb3942058
https://doi.org/10.1002/mcs.1220060109
https://doi.org/10.1002/mcs.1220060109
Autor:
Michael Schleimer, Volker Schurig
Publikováno v:
Journal of Chromatography A. 638:85-96
The synthesis of a polysiloxane containing chemically bonded chiral metal complex derived from nickel(II) bis[(3-heptafluorobutanoyl)-10-methylene-(1 R )-camphorate] (Chirasil-nickel) and its effective immobilization on the inner surface of fused-sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c7cff89122997e005adad6e44f5ef8d
https://doi.org/10.1016/0021-9673(93)85011-u
https://doi.org/10.1016/0021-9673(93)85011-u
Autor:
Martin Jung, Dieter Schmalzing, Ulrich Mühleck, Jan C. Buyten, Michael Schleimer, Philippe Mussche, Coen Duvekot, Volker Schurig
Publikováno v:
Journal of High Resolution Chromatography. 13:713-717
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a4ab6567ee45cc88bcff31b6947e76
https://doi.org/10.1002/jhrc.1240131012
https://doi.org/10.1002/jhrc.1240131012