Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael Schaber"'
Autor:
Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract 8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination a
Externí odkaz:
https://doaj.org/article/6865606e68fe4a83a2797cb46fc67eee
Autor:
Melissa Dumble, Ming-Chih Crouthamel, Shu-Yun Zhang, Michael Schaber, Dana Levy, Kimberly Robell, Qi Liu, David J Figueroa, Elisabeth A Minthorn, Mark A Seefeld, Meagan B Rouse, Sridhar K Rabindran, Dirk A Heerding, Rakesh Kumar
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100880 (2014)
Tumor cells upregulate many cell signaling pathways, with AKT being one of the key kinases to be activated in a variety of malignancies. GSK2110183 and GSK2141795 are orally bioavailable, potent inhibitors of the AKT kinases that have progressed to h
Externí odkaz:
https://doaj.org/article/332f1cf8dcff42b69e7e64f5dde37d45
Autor:
Gaochao Tian, Steven Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia Davis, Sam Duvall, Brett Kaufman, William Rumsey
8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination apurinic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf3fcdf75087760c207faf2a8a930eb
https://doi.org/10.21203/rs.3.rs-1786284/v1
https://doi.org/10.21203/rs.3.rs-1786284/v1
Autor:
Yong Jiang, Tia Lewis, Patricia M. McCormick, Michael Schaber, Beth Pietrak, Rachel D. Totoritis, Marc A. Holbert, Lawrence M. Szewczuk, Daniel Fornwald, William G. Bonnette, Geoffrey Quinque, Maggie Grimes, Rosalie E. Matico, Ed Dul, Randy K. Bledsoe, Derrick W. Meinhold, Stephanie Chen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Significant resource is spent by drug discovery project teams to generate numerous, yet unique target constructs for the multiple platforms used to drive drug discovery programs including: functional assays, biophysical studies, structural biology, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b0cbe26de02a861c13c08b95ac2b93
http://link.springer.com/article/10.1038/s41598-019-49149-2
http://link.springer.com/article/10.1038/s41598-019-49149-2
CAK1 Promotes Meiosis and Spore Formation in Saccharomyces cerevisiae in a CDC28-Independent Fashion
Autor:
Anne Lindgren, Philipp Kaldis, Karen Schindler, Michael Schaber, David Bungard, Edward Winter
Publikováno v:
Molecular and Cellular Biology. 22:57-68
CAK1 encodes a protein kinase in Saccharomyces cerevisiae whose sole essential mitotic role is to activate the Cdc28p cyclin-dependent kinase by phosphorylation of threonine-169 in its activation loop. SMK1 encodes a sporulation-specific mitogen-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee25aff7596a4fe3eb965d27bfd9193
https://doi.org/10.1128/mcb.22.1.57-68.2002
https://doi.org/10.1128/mcb.22.1.57-68.2002
Publikováno v:
Gene. 43:69-77
To investigate the properties of the fos oncogene, we have constructed bacterial and yeast vectors which express the entire fos -coded protein (Fos) and two C-terminal deletion products. In Escherichia coli , Fos proteins were expressed from the phag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491d85c093a1d2c3ed7be217fb0dfc67
https://doi.org/10.1016/0378-1119(86)90009-0
https://doi.org/10.1016/0378-1119(86)90009-0
Publikováno v:
Somatostatin ISBN: 9781468453287
Most small peptide hormones are synthesized as part of larger precursors which undergo proteolytic processing to generate the bioactive peptides (1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89eca37fc9a0dbae61962cb4bcb830b
https://doi.org/10.1007/978-1-4684-5326-3_5
https://doi.org/10.1007/978-1-4684-5326-3_5
Autor:
R Chizzonite, Michael Schaber, G Ju, Robert M. Crowl, G Kumar, M Poonian, C Miyamoto, K Rupprecht, Kramer Richard Allen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 82(21)
mRNA from human HL-60 cells was used to prepare a cDNA library, from which two full-length clones that encompass the complete c-myc coding region were isolated. One clone, pM1-11, contains all three exons of human c-myc. The second clone, pM4-10, rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329aa656de8e2c3019858aca0c3e9de0
https://pubmed.ncbi.nlm.nih.gov/3903749
https://pubmed.ncbi.nlm.nih.gov/3903749