Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael Saynisch"'
Autor:
Luisa Schmidt, Michael Saynisch, Christian Hoegsbjerg, Andreas Schmidt, Abigail Mackey, Jan-Wilm Lackmann, Stefan Müller, Manuel Koch, Bent Brachvogel, Michael Kjaer, Philipp Antczak, Marcus Krüger
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114374- (2024)
Summary: Morphological studies of skeletal muscle tissue provide insights into the architecture of muscle fibers, the surrounding cells, and the extracellular matrix (ECM). However, a spatial proteomics analysis of the skeletal muscle including the m
Externí odkaz:
https://doaj.org/article/1b4e8a745e234578800b9f4eff119bd6
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Many developing tissues require Par-driven polarization, but its role in mammalian tissue maintenance is unclear. Here, the authors show that in mouse epidermis, Par3 governs tissue homeostasis not via orientation of cell division but by coupling cel
Externí odkaz:
https://doaj.org/article/01f3c0959d3e463a953531f3edee330c
Autor:
Sandra Iden, Annika Graband, Michael Leitges, Alexandra Schwickert, Oana-Diana Persa, Carien M. Niessen, Susanne Vorhagen, Dominik Kleefisch, Michael Saynisch
Publikováno v:
Oncogene. 37:5136-5146
The polarity proteins Par3 and aPKC are key regulators of processes altered in cancer. Par3/aPKC are thought to dynamically interact with Par6 but increasing evidence suggests that aPKC and Par3 also exert complex-independent functions. Whereas aPKC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2ddabe1dbf0bd328115973dcfed364
https://doi.org/10.1038/s41388-018-0313-1
https://doi.org/10.1038/s41388-018-0313-1
Phosphorylation of the myosin regulatory light chain 2 is a post-translational modification commonly used to report for myosin ATPase activity and actomyosin contractility. While its use in cell culture has been broadly reported in several studies, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0130e1d28bd692127d7d638e6871d7a
https://doi.org/10.21203/rs.2.10178/v1
https://doi.org/10.21203/rs.2.10178/v1
Dephosphorylation of epitopes is a common way of testing phospho-specificity of antibodies. Whereas it is a regularly used protocol for dephosphorylation in cell lysates, its use in immunohistochemistry has been limited. Here we describe a methodolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d695ae9d96553b02917d4652ee1bf93
https://doi.org/10.21203/rs.2.10179/v1
https://doi.org/10.21203/rs.2.10179/v1
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Epithelial homeostasis requires balanced progenitor cell proliferation and differentiation, whereas disrupting this equilibrium fosters degeneration or cancer. Here we studied how cell polarity signaling orchestrates epidermal self-renewal and differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48246d504b309b7ad1071aa054bf3fc5
https://pubmed.ncbi.nlm.nih.gov/31358743
https://pubmed.ncbi.nlm.nih.gov/31358743
Autor:
Sina K. Knapp, Sandra Iden, Michael Saynisch, Peter Jeong, Max Schlaak, Cornelia Mauch, Jennifer Landsberg, Thomas Tüting, Marina Kranen, Melina Mescher, Carien M. Niessen, Matthias Rübsam
Publikováno v:
The Journal of Experimental Medicine
Mescher et al. uncover a novel tissue-borne tumor suppression mechanism, engaging polarity proteins in the epithelial microenvironment that prevent malignant outgrowth of neighboring cell types through control of heterologous cell–cell contacts. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2230085d24df800e7532ece0d7315c
https://www.ncbi.nlm.nih.gov/pubmed/28096290
https://www.ncbi.nlm.nih.gov/pubmed/28096290
Publikováno v:
Journal of Investigative Dermatology. 136:S181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d670c4ca2b98383c9ba0a9c9091daba
https://doi.org/10.1016/j.jid.2016.06.140
https://doi.org/10.1016/j.jid.2016.06.140