Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael Salcius"'
Autor:
Beat Nyfeler, Dominic Hoepfner, Deborah Palestrant, Christina A Kirby, Lewis Whitehead, Robert Yu, Gejing Deng, Ruth E Caughlan, Angela L Woods, Adriana K Jones, S Whitney Barnes, John R Walker, Swann Gaulis, Ervan Hauy, Saskia M Brachmann, Philipp Krastel, Christian Studer, Ralph Riedl, David Estoppey, Thomas Aust, N Rao Movva, Zuncai Wang, Michael Salcius, Gregory A Michaud, Gregory McAllister, Leon O Murphy, John A Tallarico, Christopher J Wilson, Charles R Dean
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e42657 (2012)
Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G (EF-G) as the cellular target of argyrin B in bacteria, via resistant mutant selection and
Externí odkaz:
https://doaj.org/article/8cc21bffe9b742f29677cb5ec08eb108
Autor:
Jinhai Gao, Andreas Harsch, Dong Liu, Deborah Rothman, Stephen M. Canham, Silvio Roggo, Joseph Loureiro, John A. Tallarico, Philipp Krastel, Lloyd B. Klickstein, Gregory A. Michaud, Christy Fryer, Bushell Simon, Savage Nik, Michael Salcius, Kian L. Tan, Joerg Kallen, Feng Cong, Philipp Lustenberger, Manuel Mihalic, Eric T Williams, Aude Izaac, Jian Ding, Patrick J. Devine, Xiaobo Xia, Fred Harbinski, Erhan I. Altinoglu, Shaowen Wang, Rishi K. Jain, Liling Zeng, Xiaolin Gao, Larraufie Marie-Helene
Publikováno v:
Cell chemical biology. 28(9)
Summary Acute kidney injury (AKI) is a life-threatening disease with no known curative or preventive therapies. Data from multiple animal models and human studies have linked dysregulation of bone morphogenetic protein (BMP) signaling to AKI. Small m
Autor:
Michael Salcius, David Estoppey, Markus Schirle, Jason R. Thomas, Christian Studer, Ireos Filipuzzi, Verena Pries, Dominic Hoepfner
Publikováno v:
ACS Chemical Biology. 12:2264-2269
The microbial metabolite Chivosazole F has been described to affect the cytoskeleton and to inhibit actin polymerization in vitro. Applying orthogonal genomic and proteomics approaches, we now show for the first time that Chivosazole F exerts its eff
Autor:
Kevin Xie, Favour A Akinjiyan, Frederic Sigoillot, John A. Tallarico, Jeffrey A. Chao, Judith Knehr, Eric T Williams, Matthew T. Spencer, Juan B. Rodríguez-Molina, Gregory A. Michaud, Walter Carbone, Howard R Miller, Aleem Fazal, Sarah H. Carl, Jeremy L. Jenkins, Jason Murphy, Jonathan J. Turner, Gregory J Molind, Guglielmo Roma, Felix Lohmann, Caroline G Artus-Revel, Scott Gleim, Wilhelm A. Weihofen, Aye Chen, Michael Salcius, Rohan Eric John Beckwith, John S. Reece-Hoyes, Scott M. Brittain, Nathan T. Ross, Mark Zambrowski, Geoffrey Boynton, Lori A. Passmore, Min Jia, Elizabeth George, Sven Schuierer, Chitra Saran, Martin Henault, Markus Schirle, Jason R. Thomas, Seth Carbonneau, Yuan Wang, Johannes H Wilbertz
Publikováno v:
Nature Chemical Biology. 16:479-479
Autor:
Rohan Eric John Beckwith, John A. Tallarico, Geoffrey Boynton, Jason R. Thomas, Gregory J Molind, Scott M. Brittain, Lori A. Passmore, Min Jia, Michael Salcius, Jason Murphy, Jonathan J. Turner, Seth Carbonneau, John S. Reece-Hoyes, Juan B. Rodríguez-Molina, Judith Knehr, Howard R Miller, Scott Gleim, Yuan Wang, Sven Schuierer, Martin Henault, Frederic Sigoillot, Johannes H Wilbertz, Walter Carbone, Felix Lohmann, Aye Chen, Chitra Saran, Aleem Fazal, Favour A Akinjiyan, Gregory A. Michaud, Jeremy L. Jenkins, Sarah H. Carl, Eric T Williams, Matthew T. Spencer, Guglielmo Roma, Wilhelm A. Weihofen, Elizabeth George, Markus Schirle, Kevin Xie, Mark Zambrowski, Jeffrey A. Chao, Caroline G Artus-Revel, Nathan T. Ross
Publikováno v:
Nat Chem Biol
The post-genomic era has seen many advances in our understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate multiple approaches to target even monogenic tumors. Here, we combine phenotypic screening with chemical genetics
Autor:
Keith Jendza, Mitsunori Kato, Michael Salcius, Honnappa Srinivas, Andrea De Erkenez, Anh Nguyen, Doug McLaughlin, Celine Be, Christian Wiesmann, Jason Murphy, Philippe Bolduc, Muneto Mogi, Jose Duca, Abdel Namil, Michael Capparelli, Veronique Darsigny, Erik Meredith, Ritesh Tichkule, Luciana Ferrara, Jessica Heyder, Fang Liu, Patricia A. Horton, Michael J. Romanowski, Markus Schirle, Nello Mainolfi, Karen Anderson, Gregory A. Michaud
Publikováno v:
Nature chemical biology. 15(7)
The complement pathway is an important part of the immune system, and uncontrolled activation is implicated in many diseases. The human complement component 5 protein (C5) is a validated drug target within the complement pathway, as an anti-C5 antibo
Autor:
Xiaolu Zhang, Jeffery A. Porter, Atwood K. Cheung, Vic E. Myer, Mark C. Fishman, Caroline Gubser Keller, Rajeev Sivasankaran, John A. Tallarico, Marc Hild, Sven Schuierer, Michael McLellan, Frada Berenshteyn, William F. Dietrich, Cecile Blaustein, Youngah Shin, Lei Shu, Michael Salcius, Monish Jain, Mailin Van Hoosear, Donovan N. Chin, Arnaud Lacoste, Martin Beibel, James Palacino, Nicole A. Renaud, Leo Murphy, Marcel J. J. Blommers, Lawrence G. Hamann, Caroline Bullock, Xiaoying Shi, Lin Deng, Jason R. Thomas, Daniel Curtis, Thomas M. Smith, Susanne E. Swalley, Gregory A. Michaud, Cheng Song, Brian Tseng, Guglielmo Roma, Natalie Dales, Rebecca Servais
Publikováno v:
Nature Chemical Biology. 11:511-517
Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric mortality. A duplicate copy (SMN2) is inefficiently spliced, producing a tru
Autor:
Tony R. Hazbun, Stanley Fields, Jing Huang, Gregory A. Michaud, Fulai Jin, Paul Predki, Michael Salcius
Publikováno v:
Nature Methods. 3:183-189
The generation of large-scale data sets is a fundamental requirement of systems biology. But despite recent advances, generation of such high-coverage data remains a major challenge. We developed a pooling-deconvolution strategy that can dramatically
Publikováno v:
Current Opinion in Biotechnology. 16:447-452
Arrays of immobilized proteins have been developed for the discovery and characterization of protein functions ranging from molecular recognition to enzymatic activity. The success of these applications is highly dependent upon the maintenance of pro
Autor:
Wolfgang Jahnke, Antonin V. Tutter, Qin Hao, Andras J. Bauer, Gregory A. Michaud, John A. Tallarico, Jean-Michel Rondeau, Michael Salcius, E. Bourgier, Jacob Raphael, Shu Li
Publikováno v:
Journal of biomolecular screening. 19(6)
Bioactive small molecules are an invaluable source of therapeutics and chemical probes for exploring biological pathways. Yet, significant hurdles in drug discovery often come from lacking a comprehensive view of the target(s) for both early tool mol