Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michael Saganich"'
Autor:
Donald S. Karanewsky, Guy Servant, Hanghui Liu, Bert Chi, Lily Ida, Michael Saganich, Sara Werner, Joseph R. Fotsing, Andrew Patron, Catherine Tachdjian, Amy Arthur
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 507-520 (2017)
A toxicological evaluation of N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218; CAS 1622458-34-7), a flavour with modifying properties, was completed for the purpose of assessin
Externí odkaz:
https://doaj.org/article/e104bf811a6b41778b1fd0b467f96e72
Autor:
Lan Zhang, Hanghui Liu, Brett Weylan Ching, Guy Servant, Tanya Ditschun, Andrew Patron, Thomas Brady, Mark C. Williams, Melissa Arellano, Vincent Darmohusodo, Michael Saganich, Qing Chen, Timothy Davis, Catherine Tachdjian, Donald S. Karanewsky, Joseph R. Fotsing
Publikováno v:
Journal of medicinal chemistry. 63(9)
In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blocker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bf37e3c7509316160de3e35812932e
https://pubmed.ncbi.nlm.nih.gov/32330040
https://pubmed.ncbi.nlm.nih.gov/32330040
Autor:
Bert Chi, Andrew Patron, Michael Saganich, Sara Werner, Catherine Tachdjian, Guy Servant, Amy J. Arthur, Joseph R. Fotsing, Lily Ida, Hanghui Liu, Donald S. Karanewsky
Publikováno v:
Toxicology Reports, Vol 4, Iss, Pp 507-520 (2017)
Toxicology Reports
Toxicology Reports
Graphical abstract The results of the ADME, genotoxicity, rodent toxicology and developmental toxicology studies conducted on a new flavour compound S2218 are reported. S2218 is a positive allosteric modifier (PAM) of the human sweet taste receptor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdef84c8da13f7445a16395430628f3
https://doi.org/10.1016/j.toxrep.2017.09.004
https://doi.org/10.1016/j.toxrep.2017.09.004