Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Michael S.Y. Huen"'
Autor:
Lok Hei Chan, Lei Zhou, Kai Yu Ng, Tin Lok Wong, Terence K. Lee, Rakesh Sharma, Jane H. Loong, Yick Pang Ching, Yun-Fei Yuan, Dan Xie, Chung Mau Lo, Kwan Man, Benedetta Artegiani, Hans Clevers, Helen H. Yan, Suet Yi Leung, Stéphane Richard, Xin-Yuan Guan, Michael S.Y. Huen, Stephanie Ma
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 690-701.e8 (2018)
Summary: Arginine methylation is a post-translational modification that plays pivotal roles in signal transduction and gene transcription during cell fate determination. We found protein methyltransferase 6 (PRMT6) to be frequently downregulated in h
Externí odkaz:
https://doaj.org/article/94d362baf9af4bfd950842e35b71f463
Autor:
Lin-Yu Lu, Michael S.Y. Huen, Andrew Chi-Pang Tai, De-pei Liu, Kathryn S.E. Cheah, Jian-Dong Huang
Publikováno v:
BioTechniques, Vol 44, Iss 2, Pp 217-224 (2008)
The λ phage Red recombination system has been used to modify plasmid, bacterial artificial chromosome (BAC), and chromosomal DNA in a highly precise and versatile manner. Linear double-stranded DNA fragments or synthetic single-stranded oligonucleot
Externí odkaz:
https://doaj.org/article/77b24b1535574a1d9bfd50409e3faeaf
Autor:
Terence K. Lee, KY Ng, Phillis W.F. Kau, Noélia Che, Man Tong, Stephanie Ma, Tin Lok Wong, Michael S.Y. Huen, Lok Hei Chan, Jing Ping Yun
Publikováno v:
Cancer Letters. 501:247-262
Autophagy is a critical survival factor for cancer cells, whereby it maintains cellular homeostasis by degrading damaged organelles and unwanted proteins and supports cellular biosynthesis in response to stress. Cancer cells, including hepatocellular
Publikováno v:
Nucleic Acids Research
DNA double-strand breaks (DSBs) at ribosomal gene loci trigger inhibition of ribosomal DNA (rDNA) transcription and extensive nucleolar reorganization, including the formation of nucleolar caps where rDNA DSBs engage with canonical DSB signaling and
Autor:
Michael S.Y. Huen, Raissa Ng
Publikováno v:
Genome Instability & Disease. 1:151-154
The lifespan regulator protein SIRT6 is an NAD + -dependent deacetylase that plays an early role in cellular responses to DNA damage. In a recent study from Liu, Xu and team (2020), the authors describe a novel lysine acetylation/deacetylation switch
Autor:
Xin Yi Tan, Junshi Li, Justin W.C. Leung, Kirk West, Cheng-han Yu, Shirley M.-H. Sy, Chao Dong, Toyotaka Ishibashi, Michael S.Y. Huen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cells avoid clashes between DNA repair machineries and the transcription apparatus by temporary halting gene expression in the vicinity of DNA double-strand breaks (DSBs), an emerging DNA damage response (DDR) that underlies genome integ
Autor:
Xin Yi Tan, Michael S.Y. Huen
Publikováno v:
Essays in Biochemistry. 64:705-719
Timely repair of DNA double-strand break (DSB) entails coordination with the local higher order chromatin structure and its transaction activities, including transcription. Recent studies are uncovering how DSBs trigger transient suppression of nearb
Autor:
Dongbo Ding, Qing Li, Maggie Zi-Ying Chow, Kui Ming Chan, Junhong Han, Michael S.Y. Huen, Yuchen Zhang, Toyotaka Ishibashi, Du Yang, Tze Zhen Evangeline Kang, Yi Ching Esther Wan, Lina Zhu, Xin Wang, Jiaxian Liu, Zongli Zheng, Ajay Goel, Tsz Chui Sophia Leung, Chengmin Qian, Jitian Zhang, Xulun Sun
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-4 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Autor:
L. An, Robert L. Eoff, Michael S.Y. Huen, Jiadong Wang, Zhanzhan Xu, Jessica L. Kelliher, Justin W.C. Leung, Megan R. Reed, Kirk West
Publikováno v:
Nucleic Acids Research. 47:6236-6249
The tumor suppressor protein 53BP1 plays key roles in response to DNA double-strand breaks (DSBs) by serving as a master scaffold at the damaged chromatin. Current evidence indicates that 53BP1 assembles a cohort of DNA damage response (DDR) factors
Autor:
Michael S.Y. Huen, Tian Tian, Guixing Jiang, Jun Huang, Yi Wang, Mingjie Wu, Liping Cao, Xiaomei Zhu, Ting Liu, Feiyu Xia, Jinhua Han, Li Wan
Publikováno v:
Proc Natl Acad Sci U S A
DNA end resection is a critical step in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). However, the mechanisms governing the extent of resection at DSB sites undergoing homology-directed repair remain unclear. Here,