Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Michael S. Westphall"'
Autor:
Noah M. Lancaster, Pavel Sinitcyn, Patrick Forny, Trenton M. Peters-Clarke, Caroline Fecher, Andrew J. Smith, Evgenia Shishkova, Tabiwang N. Arrey, Anna Pashkova, Margaret Lea Robinson, Nicholas Arp, Jing Fan, Juli Hansen, Andrea Galmozzi, Lia R. Serrano, Julie Rojas, Audrey P. Gasch, Michael S. Westphall, Hamish Stewart, Christian Hock, Eugen Damoc, David J. Pagliarini, Vlad Zabrouskov, Joshua J. Coon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles in myriad cell processes. That said, detecting and quantifying protein phosphorylation has remained a challenge. We describe the use of a novel
Externí odkaz:
https://doaj.org/article/06a4611f710d4885ae910c3dc977ec18
Autor:
Michael S. Westphall, Kenneth W. Lee, Austin Z. Salome, Jean M. Lodge, Timothy Grant, Joshua J. Coon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
Mass spectrometry (MS) is a powerful tool for the structural characterization of protein complexes. Here the authors offer a path for direct integration of MS and electron microscopy with a MS approach that enables grid deposition and structural pres
Externí odkaz:
https://doaj.org/article/6e45a8f643a24a1f9f34b640053ec2a6
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mass spectrometry facilitates large-scale glycosylation profiling but in-depth analysis of intact glycopeptides is still challenging. Here, the authors show that activated ion electron transfer dissociation is suitable for glycopeptide fragmentation
Externí odkaz:
https://doaj.org/article/db34920cf377464b93976745b85dbd71
Autor:
Dain R. Brademan, Ian J. Miller, Nicholas W. Kwiecien, David J. Pagliarini, Michael S. Westphall, Joshua J. Coon, Evgenia Shishkova
Publikováno v:
Patterns, Vol 1, Iss 7, Pp 100122- (2020)
Summary: Researchers now generate large multi-omic datasets using increasingly mature mass spectrometry techniques at an astounding pace, facing new challenges of “Big Data” dissemination, visualization, and exploration. Conveniently, web-based d
Externí odkaz:
https://doaj.org/article/cca67b4f95a24e44a73d4f6683883400
Autor:
Sara C. Buch-Larsen, Ivo A. Hendriks, Jean M. Lodge, Martin Rykær, Benjamin Furtwängler, Evgenia Shishkova, Michael S. Westphall, Joshua J. Coon, Michael L. Nielsen
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108176- (2020)
Summary: ADP-ribosylation (ADPr) is a post-translational modification that plays pivotal roles in a wide range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under physiological conditions, without relying on genetic or chemical
Externí odkaz:
https://doaj.org/article/2654f52b97fc441ca4c7c1706ad65f8a
Autor:
Joshua M. Baughman, Christopher M. Rose, Ganesh Kolumam, Joshua D. Webster, Emily M. Wilkerson, Anna E. Merrill, Timothy W. Rhoads, Rajkumar Noubade, Paula Katavolos, Justin Lesch, Donald S. Stapleton, Mary E. Rabaglia, Kathy L. Schueler, Raymond Asuncion, Melanie Domeyer, Jose Zavala-Solorio, Michael Reich, Jason DeVoss, Mark P. Keller, Alan D. Attie, Alexander S. Hebert, Michael S. Westphall, Joshua J. Coon, Donald S. Kirkpatrick, Anwesha Dey
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 583-595 (2016)
We introduce neutron-encoded (NeuCode) amino acid labeling of mice as a strategy for multiplexed proteomic analysis in vivo. Using NeuCode, we characterize an inducible knockout mouse model of Bap1, a tumor suppressor and deubiquitinase whose in vivo
Externí odkaz:
https://doaj.org/article/8cdbcd1118fe43d0a32e0e75203ce3e3
Autor:
Justin Brumbaugh, Jason D. Russell, Pengzhi Yu, Michael S. Westphall, Joshua J. Coon, James A. Thomson
Publikováno v:
Stem Cell Reports, Vol 2, Iss 1, Pp 18-25 (2014)
NANOG is a divergent homeobox protein and a core component of the transcriptional circuitry that sustains pluripotency and self-renewal. Although NANOG has been extensively studied on the transcriptional level, little is known regarding its posttrans
Externí odkaz:
https://doaj.org/article/3cdff99f7e004eb9a0faa2a15bea5c2e
Autor:
David H. Keating, Yaoping Zhang, Irene M. Ong, Sean McIlwain, Eduardo H. Morales, Jeffrey A. Grass, Mary Tremaine, William Bothfeld, Alan Higbee, Arne Ulbrich, Allison J. Balloon, Michael S. Westphall, Josh Aldrich, Mary S. Lipton, Joonhoon Kim, Oleg V. Moskvin, Yury V. Bukhman, Joshua J. Coon, Patricia J. Kiley, Donna M. Bates, Robert Landick
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
Efficient microbial conversion of lignocellulosic hydrolysates to biofuels is a key barrier to the economically viable deployment of lignocellulosic biofuels. A chief contributor to this barrier is the impact on microbial processes and energy metabol
Externí odkaz:
https://doaj.org/article/001cf026d0fd4b66bde5e420055ed7c7
Autor:
Christopher M. Rose, Muthusubramanian eVenkateshwaran, Paul A. Grimsrud, Michael S. Westphall, Michael R. Sussman, Joshua J. Coon, Jean-Michel eAné
Publikováno v:
Frontiers in Plant Science, Vol 3 (2012)
The ability of legume crops to fix atmospheric nitrogen via a symbiotic association with soil rhizobia makes them an essential component of many agricultural systems. Initiation of this symbiosis requires protein phosphorylation-mediated signaling in
Externí odkaz:
https://doaj.org/article/25095be82f96455bb7e191b19dbac443
Autor:
Pavel Sinitcyn, Alicia L. Richards, Robert J. Weatheritt, Dain R. Brademan, Harald Marx, Evgenia Shishkova, Jesse G. Meyer, Alexander S. Hebert, Michael S. Westphall, Benjamin J. Blencowe, Jürgen Cox, Joshua J. Coon
Publikováno v:
Nature Biotechnology.
An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically identified by peptide sequences representing a small fraction of their total amino acids. Hence, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::960929f94e68f3337d5613ac6be43a00
https://doi.org/10.1038/s41587-023-01714-x
https://doi.org/10.1038/s41587-023-01714-x