Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael S. Valerio"'
Autor:
Molly E. Baumann, Nina Rossa Haddad, Alyssa Salazar, W. Lee Childers, Shawn Farrokhi, Neil B. Goldstein, Brad D. Hendershot, Lisa Reider, Richard E. Thompson, Michael S. Valerio, Christopher L. Dearth, Luis A. Garza
Publikováno v:
JID Innovations, Vol 4, Iss 4, Pp 100276- (2024)
In persons with limb loss, prosthetic devices cause skin breakdown, largely because residual limb skin (nonvolar) is not intended to bear weight such as palmoplantar (volar) skin. Before evaluation of treatment efficacy to improve skin resiliency, ef
Externí odkaz:
https://doaj.org/article/5478eb289fab4a64b2a85b172f5b185b
Autor:
Joseph G. Wasser, Brad D. Hendershot, Julian C. Acasio, Lauren D. Dodd, Rebecca L. Krupenevich, Alison L. Pruziner, Ross H. Miller, Stephen M. Goldman, Michael S. Valerio, Lien T. Senchak, Mark D. Murphey, David A. Heltzel, Michael G. Fazio, Christopher L. Dearth, Nelson A. Hager
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Motivated by the complex and multifactorial etiologies of osteoarthritis, here we use a comprehensive approach evaluating knee joint health after unilateral lower limb loss. Thirty-eight male Service members with traumatic, unilateral lower
Externí odkaz:
https://doaj.org/article/29cb210a29fe453680c21b0c545f086d
Autor:
Connor P. Dolan, Andrew R. Clark, Jessica M. Motherwell, Naveena B. Janakiram, Michael S. Valerio, Christopher L. Dearth, Stephen M. Goldman
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Volumetric muscle loss (VML)—defined as the irrecoverable loss of skeletal muscle tissue with associated persistent functional deficits—is among the most common and highly debilitating combat-related extremity injuries. This is particula
Externí odkaz:
https://doaj.org/article/72d56c9fcf8c4affa8c56f65a116b70e
Autor:
Michael S. Valerio, Jorge B. Edwards, Connor P. Dolan, Jessica M. Motherwell, Benjamin K. Potter, Christopher L. Dearth, Stephen M. Goldman
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13606 (2023)
Intra-articular fractures (IAF) result in significant and prolonged inflammation, increasing the chances of developing post-traumatic osteoarthritis (PTOA). Interleukin-one beta (IL-1β) and Tumor Necrosis Factor-alpha (TNF-α) are key inflammatory f
Externí odkaz:
https://doaj.org/article/3ecbc5f450154f619bdb00ca4c57342d
Autor:
Michael S. Valerio, William A. Pace, Connor P. Dolan, Jorge B. Edwards, Naveena B. Janakiram, Benjamin K. Potter, Christopher L. Dearth, Stephen M. Goldman
Publikováno v:
Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)
Abstract Purpose This study aimed to develop and characterize a closed intra‐articular fracture (IAF) mediated post‐traumatic osteoarthritis (PTOA) model in rats to serve as a testbed for putative disease modifying interventions. Methods Male rat
Externí odkaz:
https://doaj.org/article/1e4fcf24e98346fcb7327fb4551df014
Autor:
Connor P. Dolan, Michael S. Valerio, W. Lee Childers, Stephen M. Goldman, Christopher L. Dearth
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-4 (2021)
Extremity injuries occur frequently during warfare. While traditionally treated in definitive clinics, the future battlefield is projected to be different in a variety of ways, and there will likely be a shift towards prolonged field care (PFC) for t
Externí odkaz:
https://doaj.org/article/656b79fb40054ce68047ed878f8888d4
Autor:
Jessica M. Motherwell, Connor P. Dolan, Sergey S. Kanovka, Jorge B. Edwards, Sarah R. Franco, Naveena B. Janakiram, Michael S. Valerio, Stephen M. Goldman, Christopher L. Dearth
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3564 (2023)
The use of a rehabilitation approach that promotes regeneration has the potential to improve the efficacy of pro-regenerative therapies and maximize functional outcomes in the treatment of volumetric muscle loss (VML). An adjunct antifibrotic treatme
Externí odkaz:
https://doaj.org/article/f716c839762c46308ded1fdba9246cbc
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13552 (2021)
Composite tissue injuries (CTI) are common among US Military Service members during combat operations, and carry a high potential of morbidity. Furthermore, CTI are often complicated due to an altered wound healing response, resulting in part from a
Externí odkaz:
https://doaj.org/article/d4619ac0a36441fa88bd828a58afdb19
Autor:
Sarah R. Franco, Christopher L. Dearth, Jessica M. Motherwell, Stephen M. Goldman, Michael S Valerio, Naveena B. Janakiram, Connor P. Dolan
Publikováno v:
Acta Biomaterialia. 140:379-388
Volumetric muscle loss (VML) was defined as the frank loss of skeletal muscle tissue with associated chronic functional deficits. Significant effort has been dedicated to developing approaches for treating VML injuries, most of which have focused on
Publikováno v:
Cell and Tissue Research. 385:149-159
Biologic scaffolds (BS) are the most widely studied therapeutics for the treatment of volumetric muscle loss (VML) owing to their purported effects on cell proliferation, chemotaxis, migration, and differentiation. Despite these claims, variability i