Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael S. Schappe"'
Autor:
Michael S. Schappe, Marta E. Stremska, Gregory W. Busey, Taylor K. Downs, Philip V. Seegren, Suresh K. Mendu, Zachary Flegal, Catherine A. Doyle, Eric J. Stipes, Bimal N. Desai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Efficient removal of apoptotic cells by phagocytosis underlies tissue development, wound repair, host defense and organ homeostasis. Here, authors identify TRPM7 as a regulator of cargo acidification and Ca2+ signaling during apoptotic cell clearance
Externí odkaz:
https://doaj.org/article/91b4d7f5e2564ec69283f69be2f00ae0
Autor:
Suresh K. Mendu, Marta E. Stremska, Bimal N. Desai, Julia K. Krupa, Clare A. Parker, Michael S. Schappe, Eric J. Stipes, Jason S. Rogers, Justin S. A. Perry, Emily K. Moser, Thomas J. Braciale
Publikováno v:
Sci Signal
The thymic development of regulatory T (T(reg)) cells, crucial suppressors of the responses of effector T (T(eff)) cells, is governed by the transcription factor FOXP3. Despite the clinical importance of T(reg) cells, there is a dearth of druggable m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d82adb853980e9002ca0667da87e572
https://doi.org/10.1126/scisignal.abb0619
https://doi.org/10.1126/scisignal.abb0619
Publikováno v:
The Journal of General Physiology
Chiu and colleagues review the primary evidence for divergent activation mechanisms and unitary properties of Pannexin 1 channels.
Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activat
Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b208d8af10a9f5f31d8132c0d37e7d5
https://doi.org/10.1085/jgp.201711888
https://doi.org/10.1085/jgp.201711888
Autor:
Michael S, Schappe, Marta E, Stremska, Gregory W, Busey, Taylor K, Downs, Philip V, Seegren, Suresh K, Mendu, Zachary, Flegal, Catherine A, Doyle, Eric J, Stipes, Bimal N, Desai
Publikováno v:
Nature communications. 13(1)
Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is fundamental to developmental biology, organ physiology, and immunology. Macrophages use multiple mechanisms to detect and engulf apoptotic cells, but the signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24c7eae980eec238d9a908d8e8bca226
https://pubmed.ncbi.nlm.nih.gov/35680919
https://pubmed.ncbi.nlm.nih.gov/35680919
Autor:
Michael S. Schappe, Bimal N. Desai
Publikováno v:
Bio-protocol. 8(14)
After recognizing extracellular bacterial lipopolysaccharide (LPS), the toll-like receptor 4 (TLR4)-CD14 signaling complex initiates two distinct signaling pathways-one from the plasma membrane and the other from the signaling endosomes (Kagan et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14d12ebaef4eed5ca74b76a713f6b00
https://pubmed.ncbi.nlm.nih.gov/30112425
https://pubmed.ncbi.nlm.nih.gov/30112425
Autor:
Akshaya K. Meher, Michael S. Schappe, Dory E. DeWeese, Paxton Voigt, Clint M Upchurch, Bimal N. Desai, Vlad Serbulea, Norbert Leitinger
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(27)
Adipose tissue macrophages (ATMs) adapt their metabolic phenotype either to maintain lean tissue homeostasis or drive inflammation and insulin resistance in obesity. However, the factors in the adipose tissue microenvironment that control ATM phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3b04d0a394e1c90cf721bba0b6340f
https://pubmed.ncbi.nlm.nih.gov/29891687
https://pubmed.ncbi.nlm.nih.gov/29891687
Autor:
Michael S. Schappe, Suresh K. Mendu, Julia K. Krupa, Eric J. Stipes, Emily K. Moser, Jason S. Rogers, Clare A. Parker, Bimal N. Desai, Thomas J. Braciale
In BriefGenetic deletion of Trpm7 in T-cells or pharmacological inhibition of TRPM7 channel promotes the development of fully functional Treg cells by increasing IL-2Rα and STAT5-dependent FOXP3 expression in the developing thymocytes. The study ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea3e524fb619577d530826fb3e9a7ea
https://doi.org/10.1101/330233
https://doi.org/10.1101/330233
Autor:
Michael S, Schappe, Kalina, Szteyn, Marta E, Stremska, Suresh K, Mendu, Taylor K, Downs, Philip V, Seegren, Michelle A, Mahoney, Sumeet, Dixit, Julia K, Krupa, Eric J, Stipes, Jason S, Rogers, Samantha E, Adamson, Norbert, Leitinger, Bimal N, Desai
Publikováno v:
Immunity. 48(1)
Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f2f62d7f5bbddeafebef5fef9e00da1
https://pubmed.ncbi.nlm.nih.gov/29343439
https://pubmed.ncbi.nlm.nih.gov/29343439
Autor:
Julia K. Krupa, Gregory W. Brown, Michael S. Schappe, Suresh K. Mendu, Monica W. Buckley, Yu-Hsin Chiu, Vesna Jevtovic-Todorovic, Janelle L. Weaver, Jin K Kim, Shaofang Shu, Joyce Chung, Kodi S. Ravichandran, Sanja Arandjelovic, Bimal N. Desai, Douglas A. Bayliss
Publikováno v:
Scientific Reports
Neuropathic pain symptoms respond poorly to available therapeutics, with most treated patients reporting unrelieved pain and significant impairment in daily life. Here, we show that Pannexin 1 (Panx1) in hematopoietic cells is required for pain-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab13ca4dfc20969568f8df0b47a3d9c2
Autor:
Norbert Leitinger, Julia K. Krupa, Kalina Szteyn, Taylor K Downs, Eric J. Stipes, Jason S. Rogers, Bimal N. Desai, Marta E. Stremska, Michelle A. Mahoney, Philip V. Seegren, Michael S. Schappe, Samantha E. Adamson, Suresh K. Mendu, Sumeet Dixit
Publikováno v:
Immunity. 48:59-74.e5
Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::860a3b496cc6be489272cb40bc2de44e
https://doi.org/10.1016/j.immuni.2017.11.026
https://doi.org/10.1016/j.immuni.2017.11.026