Zobrazeno 1 - 10
of 483
pro vyhledávání: '"Michael S. Sacks"'
Autor:
Xinzeng Feng, Yifei Liu, David Kamensky, David W. McComb, Christopher K. Breuer, Michael S. Sacks
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Genetically modified mouse models provide a versatile and efficient platform to extend our understanding of the underlying disease processes and evaluate potential treatments for congenital heart valve diseases. However, applications have be
Externí odkaz:
https://doaj.org/article/cc32eab84353481db45cc39c93d1189d
Autor:
Bruno V. Rego, Amir H. Khalighi, Eric K. Lai, Robert C. Gorman, Joseph H. Gorman, Michael S. Sacks
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Each year, more than 40,000 people undergo mitral valve (MV) repair surgery domestically to treat regurgitation caused by myocardial infarction (MI). Although continual MV tissue remodelling following repair is believed to be a major contrib
Externí odkaz:
https://doaj.org/article/f131bd5421044b7fa1bbf0c0e2cf54fa
Autor:
Toni M. West, Daniel P. Howsmon, Miles W. Massidda, Helen N. Vo, Athena A. Janobas, Aaron B. Baker, Michael S. Sacks
Publikováno v:
APL Bioengineering, Vol 7, Iss 2, Pp 026101-026101-14 (2023)
Aortic valves (AVs) undergo unique stretch histories that include high rates and magnitudes. While major differences in deformation patterns have been observed between normal and congenitally defective bicuspid aortic valves (BAVs), the relation to u
Externí odkaz:
https://doaj.org/article/c808399f09f84faf9c750b9a88fc375b
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Calcific aortic valve disease (CAVD) is characterized by progressive stiffening of aortic valve (AV) tissues, inducing stenosis and insufficiency. Bicuspid aortic valve (BAV) is a common congenital defect in which the AV has two leaflets rather than
Externí odkaz:
https://doaj.org/article/0902442305f54c9d8313db48197dffc1
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Murine animal models are an established standard in translational research and provides a potential platform for studying heart valve disease. To date, studies on heart valve disease using murine models have been hindered by a lack of approp
Externí odkaz:
https://doaj.org/article/2622d5b5e0b140f4aadaecd9ce8af04e
Autor:
Hao Liu, João S. Soares, John Walmsley, David S. Li, Samarth Raut, Reza Avazmohammadi, Paul Iaizzo, Mark Palmer, Joseph H. Gorman, Robert C. Gorman, Michael S. Sacks
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Myocardial infarction (MI) rapidly impairs cardiac contractile function and instigates maladaptive remodeling leading to heart failure. Patient-specific models are a maturing technology for developing and determining therapeutic modalities f
Externí odkaz:
https://doaj.org/article/82d45691d36245a6ae9cd5b612ac0300
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The pericardium is a thin connective tissue membrane that surrounds the heart and is an integral regulatory component of cardiopulmonary performance. Pathological growth and remodeling of the right ventricle (RV) stemming from structural heart diseas
Externí odkaz:
https://doaj.org/article/c415a56ddc7a4c21ab4f41ff387e8efb
Publikováno v:
SoftwareX, Vol 11, Iss , Pp - (2020)
Tracking the deformation of fiducial markers in the vicinity of living cells embedded in compliant synthetic or biological gels is a powerful means to study cell mechanics and mechanobiology in three-dimensional environments. However, current approac
Externí odkaz:
https://doaj.org/article/e3cffc32e9824d02870cbf352da8a177
Autor:
Wanda Anselmo, Emanuela Branchetti, Juan B. Grau, Gen Li, Salma Ayoub, Eric K. Lai, Nancy Rioux, Artak Tovmasyan, Jacqueline H. Fortier, Michael S. Sacks, Ines Batinic‐Haberle, Stanley L. Hazen, Robert J. Levy, Giovanni Ferrari
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)
Background Aortic valve sclerosis (AVSc), the early asymptomatic presentation of calcific aortic valve (AV) disease, affects 25% to 30% of patients aged >65 years. In vitro and ex vivo experiments with antioxidant strategies and antagonists of osteog
Externí odkaz:
https://doaj.org/article/dde9ec6fe3aa4a8d96773f055c9f4c38
Autor:
Karthik M. Kodigepalli, Kaitlyn Thatcher, Toni West, Daniel P. Howsmon, Frederick J. Schoen, Michael S. Sacks, Christopher K. Breuer, Joy Lincoln
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 4, p 57 (2020)
Heart valves are dynamic structures that, in the average human, open and close over 100,000 times per day, and 3 × 109 times per lifetime to maintain unidirectional blood flow. Efficient, coordinated movement of the valve structures during the cardi
Externí odkaz:
https://doaj.org/article/6e86fe313d5d4d658d8ca09575af335f