Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Michael S. Lebowitz"'
Autor:
Noa G. Holtzman, Michael S. Lebowitz, Rima Koka, Maria R. Baer, Kanam Malhotra, Amir Shahlaee, Hossein A. Ghanbari, Søren M. Bentzen, Ashkan Emadi
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundAspartate β-hydroxylase (ASPH) is an embryonic transmembrane protein aberrantly upregulated in cancer cells, associated with malignant transformation and, in some reports, with poor clinical prognosis.ObjectiveTo report the expression patt
Externí odkaz:
https://doaj.org/article/f86fb60e39bc4aa5ab5969a96ee00ea4
Autor:
Yoshifumi Iwagami, Sarah Casulli, Katsuya Nagaoka, Miran Kim, Rolf I. Carlson, Kosuke Ogawa, Michael S. Lebowitz, Steve Fuller, Biswajit Biswas, Solomon Stewart, Xiaoqun Dong, Hossein Ghanbari, Jack R. Wands
Publikováno v:
Heliyon, Vol 3, Iss 9 (2017)
Background and aims: Hepatocellular carcinoma (HCC) is a difficult to treat tumor with a poor prognosis. Aspartate β-hydroxylase (ASPH) is a highly conserved enzyme overexpressed on the cell surface of both murine and human HCC cells. Methods: We ev
Externí odkaz:
https://doaj.org/article/a8d450ab73fd4cff99ad7eeec69711d0
Autor:
Michael S Lebowitz, Chun-Hsien Chen, Jiming Zhou, Chia-Ru Chung, Ying-Hao Wen, Jang-Jih Lu, Steve Shi, Min-Hsien Wu, Hsin-Yao Wang
Publikováno v:
Cancers, Vol 12, Iss 1442, p 1442 (2020)
Cancers
Volume 12
Issue 6
Cancers
Volume 12
Issue 6
Background: Tumor markers are used to screen tens of millions of individuals worldwide at annual health check-ups, especially in East Asia. Machine learning (ML)-based algorithms that improve the diagnostic accuracy and clinical utility of these test
Autor:
Alfred Morgenstern, Ekaterina Dadachova, Muctarr A. Sesay, Susan Walker, Ekaterina Revskaya, Zewei Jiang, Michael S. Lebowitz, Claudia Gravekamp, Steven Fuller, Hossein A. Ghanbari, Frank Bruchertseifer
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 32:57-65
There is a need for novel effective and safe therapies for metastatic breast cancer based on targeting tumor-specific molecular markers of cancer. Human aspartyl (asparaginyl) β-hydroxylase (HAAH) is a highly conserved enzyme that hydroxylates epide
Autor:
Songhua Zhang, Jack R. Wands, Steve Fuller, Zhi-Gang Jiang, Katsuya Nagaoka, Xuewei Bai, Kosuke Ogawa, Rolf I. Carlson, Hossein A. Ghanbari, Yanmei Zhou, Xiaoqun Dong, Michael S. Lebowitz
Publikováno v:
Cancer Lett
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with very limited treatment options. Antibody drug conjugates (ADCs) are promising cytotoxic agents capable of highly selective delivery. Aspartate-β-hydroxylase (ASPH) is
Autor:
Hossein A. Ghanbari, Csiki Ildiko, Steven Fuller, Hong Dai, Michael S. Lebowitz, Kanam Malhotra
Publikováno v:
Cancer Research. 79:1454-1454
SNS-301 is a first-in-class immunotherapeutic cancer vaccine candidate targeting human aspartate β-hydroxylase (ASPH). ASPH is an oncofetal antigen expressed in multiple human cancers but not in healthy adult tissue. As a biologic modifier of the NO
Autor:
Michael S. Lebowitz, Amir H. Shahlaee, Maria R. Baer, Hossein A. Ghanbari, Kanam Malhotra, Ashkan Emadi, Søren M. Bentzen, Noa G. Holtzman, Steven Fuller, Rima Koka
Publikováno v:
Blood. 132:5273-5273
Introduction Despite recent advances in treatment, acute myeloid leukemia (AML) remains difficult to cure with high rates of relapse. Relapsed/refractory AML patients who are elderly or unfit for cytotoxic chemotherapy and whose disease fails to resp
Autor:
Steven Fuller, Michael S. Lebowitz, Susan Walker, Hossein A. Ghanbari, Solomon Stewart, Wu Samindhi M
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts We are evaluating the immunogenicity and efficacy of a nanoparticle vaccine (NPV) targeting the tumor marker human aspartyl (asparaginyl) β-hydroxylase (HAAH). HAAH is an embryonic protein that is over-expressed on the surface of c
Autor:
Scott A. Burton, Susan Walker, Leonard Y. Chu, Steven Fuller, Allan Bohlke, Michael S. Lebowitz, Vinh Hua, Solomon Stewart, Hossein A. Ghanbari
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts We are evaluating the immunogenicity and efficacy of a nanoparticle vaccine (NPV) targeting the tumor marker human aspartyl (asparaginyl) β-hydroxylase (HAAH). HAAH is an embryonic protein that is over-expressed on the surface of c
Autor:
Timothy D. Veenstra, Nikolai Daraselia, Elizabeth J. Haanes, Mark A. Semenuk, Yuriy Gusev, Michael S. Lebowitz, Gradimir Georgevich, Elena Schwartz, Mark Rochman, Branka M. Bogunovic
Publikováno v:
Recent Patents on Biomarkerse. 1:222-240
The use of biomarkers for the diagnosis, prognosis, and monitoring of disease; as well as to guide the choice of therapeutic regimens is predicted to be one of the leading priorities in clinical practice. The sheer complexity of the human cell, inclu