Zobrazeno 1 - 10
of 387
pro vyhledávání: '"Michael S. Lawrence"'
Autor:
Yasha Butt, Ramin Sakhtemani, Rukshana Mohamad-Ramshan, Michael S. Lawrence, Ashok S. Bhagwat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The APOBEC3 enzymes convert cytosines in single-stranded DNA to uracils to protect against viruses and retrotransposons but can contribute to mutations that diversify tumors. To understand the mechanism of mutagenesis, we map the uracils res
Externí odkaz:
https://doaj.org/article/820624b331134de1a53888915fff2f2b
Autor:
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S. Chen, Reuben S. Harris, Michael S. Lawrence, Rémi Buisson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially targets single-stranded DNAs, with a noted affinity for DNA regions that a
Externí odkaz:
https://doaj.org/article/242d0a53917f49e5bc6d9be8d45bb23e
Autor:
Haibo Yang, Emily M. Lachtara, Xiaojuan Ran, Jessica Hopkins, Parasvi S. Patel, Xueping Zhu, Yao Xiao, Laiyee Phoon, Boya Gao, Lee Zou, Michael S. Lawrence, Li Lan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in
Externí odkaz:
https://doaj.org/article/98680727c35b4bf0a0a9d6b0cc5aec93
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-7 (2022)
Abstract Head and Neck Squamous Cell Carcinoma (HNSCC) is an aggressive epithelial cancer with poor overall response rates to checkpoint inhibitor therapy (CPI) despite CPI being the recommended treatment for recurrent or metastatic HNSCC. Mechanisms
Externí odkaz:
https://doaj.org/article/d934c79c59bc4b6fbf3d73b2e7013bb4
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
Autor:
Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112129- (2023)
Summary: TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influen
Externí odkaz:
https://doaj.org/article/d7cf1d03230041eaa0fc9ddd6ef3a6cf
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101991- (2023)
Summary: Computational pipelines for chromatin immunoprecipitation sequencing analysis can neglect colocalization events that occur in a mere subset of the genome. Here, we detail a streamlined approach for assessing colocalization of chromatin-bound
Externí odkaz:
https://doaj.org/article/ced0e3c176b448b6a3d7d5ed9577cfcd
Autor:
Nana Chen, Gabriel Golczer, Subhoshree Ghose, Brian Lin, Adam Langenbucher, Jason Webb, Haymanti Bhanot, Nicholas B. Abt, Derrick Lin, Mark Varvares, Martin Sattler, Ann Marie Egloff, Richard Joh, Ravindra Uppaluri, Kevin S. Emerick, Michael S. Lawrence, Srinivas Vinod Saladi
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110970- (2022)
Summary: Analysis of The Cancer Genome Atlas and other published data of head and neck squamous cell carcinoma (HNSCC) reveals somatic alterations of the Hippo-YAP pathway in approximately 50% of HNSCC. Better strategies to target the YAP1 transcript
Externí odkaz:
https://doaj.org/article/13be6881b6a64f958b845f078f8a66c3
Autor:
Adam Langenbucher, Danae Bowen, Ramin Sakhtemani, Elodie Bournique, Jillian F. Wise, Lee Zou, Ashok S. Bhagwat, Rémi Buisson, Michael S. Lawrence
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimal
Externí odkaz:
https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d50
Autor:
Matthew A. Reyna, David Haan, Marta Paczkowska, Lieven P. C. Verbeke, Miguel Vazquez, Abdullah Kahraman, Sergio Pulido-Tamayo, Jonathan Barenboim, Lina Wadi, Priyanka Dhingra, Raunak Shrestha, Gad Getz, Michael S. Lawrence, Jakob Skou Pedersen, Mark A. Rubin, David A. Wheeler, Søren Brunak, Jose M. G. Izarzugaza, Ekta Khurana, Kathleen Marchal, Christian von Mering, S. Cenk Sahinalp, Alfonso Valencia, PCAWG Drivers and Functional Interpretation Working Group, Jüri Reimand, Joshua M. Stuart, Benjamin J. Raphael, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/2e68c62b177945e9b33b29c835967c66
Autor:
Pégah Jalili, Danae Bowen, Adam Langenbucher, Shinho Park, Kevin Aguirre, Ryan B. Corcoran, Angela G. Fleischman, Michael S. Lawrence, Lee Zou, Rémi Buisson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven
Externí odkaz:
https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c