Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Michael S. Kobrin"'
1
Expression of a truncated EGF receptor is associated with inhibition of pancreatic cancer cell growth and enhanced sensitivity to cisplatinum
Autor: Markus W. Büchler, Kristi M. van Nostrand, Christopher Hope, Tracy Cao, Martha E. Lopez, Michael S. Kobrin, M. Wagner, Hung Fan, Murray Korc
Publikováno v: International Journal of Cancer. 68:782-787
Human pancreatic cancers over-express the epidermal growth factor receptor (EGF-R) and all 5 known ligands of the EGF family, including EGF, transforming growth factor-alpha (TGF-alpha), amphiregulin, betacellulin and heparin-binding EGF-like growth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21106325ddca0ae0dfd9c253ab644b0b
https://doi.org/10.1002/(sici)1097-0215(19961211)68:6<782::aid-ijc16>3.0.co
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2
Epidermal growth factor receptor expression in pancreatic lesions induced in the rat by azaserine
Autor: I. Seifert-Bock, R.A. de Weger, Michael S. Kobrin, C.J.T. Visser, R. A. Woutersen, Murray Korc, W. T. M. Van Blokland
Publikováno v: British Journal of Cancer, 1, 74, 92-98
British Journal of Cancer
In the present study, the expression of the epidermal growth factor receptor (EGFR) was investigated in putative preneoplastic and neoplastic acinar cell lesions induced in the rat pancreas by azaserine, using Northern blotting, in situ hybridisation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cd019049901cfb0621cf95842c5ca5
https://doi.org/10.1038/bjc.1996.321
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3
A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling
Autor: Murray Korc, Christopher Hope, Michael S. Kobrin, Lynn Speck, Tetsuya Moriai
Publikováno v: Proceedings of the National Academy of Sciences. 91:10217-10221
Epidermal growth factor (EGF) and type alpha transforming growth factor (TGF-alpha) bind to a specific region in subdomain III of the extracellular portion of the EGF receptor (EGFR). Binding leads to receptor dimerization, auto-and transphosphorylat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fdd3bbd91e736e76bfd146561c5b6a
https://doi.org/10.1073/pnas.91.21.10217
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4
A Subgroup of Patients with Chronic Pancreatitis Overexpress the c-erb B-2 Protooncogene
Autor: Helmut Friess, Hans G. Beger, Markus W. Büchler, Murray Korc, Yoichiro Yamanaka, Michael S. Kobrin, Kai Hammer
Publikováno v: Annals of Surgery. 220:183-192
OBJECTIVE: Chronic pancreatitis (CP) is a chronic condition associated with pancreatic fibrosis. A small subgroup of patients with CP develop enlargement of the head of the pancreas (EHP). This study examined some of the mechanisms that may lead to t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cacc37a6607482b20b4d9ff5eaad574
https://doi.org/10.1097/00000658-199408000-00010
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5
Induction and Expression of Heparin-Binding EGF-Like Growth Factor in Human Pancreatic Cancer
Autor: Michael S. Kobrin, Markus W. Büchler, Hitoshi Funatomi, Peter Stathis, Helmut Friess, Murray Korc
Publikováno v: Biochemical and Biophysical Research Communications. 202:1705-1709
Heparin-binding EGF-like growth factor (HB-EGF) is a polypeptide with an apparent molecular weight of 22 kilodalton that is related to epidermal growth factor (EGF) and that binds and activates the EGF receptor. We examined HB-EGF biological action a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0150c463db833a071a66406a1ab42244
https://doi.org/10.1006/bbrc.1994.2131
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6
Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis
Autor: Murray Korc, Helmut Friess, Markus W. Büchler, Eiichi Tahara, Yoichiro Yamanaka, Michael S. Kobrin
Publikováno v: International Journal of Cancer. 56:668-674
Cripto is a 188 amino-acid protein containing a central segment that shares amino-acid sequence homology with epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The EGF receptor, EGF and TGF-alpha are expressed in the nor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5ae1fde5cfe2a790f751e498bcc68c
https://doi.org/10.1002/ijc.2910560511
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7
Contents, Vol. 11, 1994
Autor: M.W. Büchler, P. Vock, L. Fernández-Cruz, St. Hürlimann, Michael S. Kobrin, Dik J. Kwekkeboom, Holger Kalthoff, H.G. Beger, Rudolf W. Ammann, H. Friess, S. Gonzalez, H. Frieß, Myriam Delhaye, Alain Vandermeeren, Wolff Schmiegel, Jacques Devière, L. Salvador, Ch.A. Seller, V. Di Carlo, M. Prados, S.R. Bramhall, Markus W. Büchler, Sven N. Reske, Leslie I. Gold, Jean Claude Reubi, K.-H. Link, Jakob R. Izbicki, M. Wagner, Parviz M. Pour, Gerhard Glatting, W. Uhl, K. Gyr, J.E.J. Krige, Helmut Friess, Dale E. Bockman, Canton J. Young, Jens C. Stollfuss, M. Falconi, Guido Adler, L. De Santis, Gisli H. Sigurdsson, I.M. Modlin, Michael G. Sarr, Jon S. Odorico, K.E. Gyr, H.U. Baer, Waldemar Uhl, Nicholas A. Wright, Michel Cremer, Hans Weidenbach, J. Lange, David L. Can-Locke, P. Aeberhard, Jan Axelson, R.F. Meier, E. Caldiron, C.W. Imrie, Arthur Zimmermann, Peter Malfertheiner, G.P. Lawton, Ch. Stoupis, P. Pederzoli, Christian Roeder, Günter Klöppel, Ch. Becker, J. Pillasch, M. Ebert, M. Thumshirn, Gregor Dornschneider, Adrian Schmassmann, Jürgen Triller, B. Hofbauer, Wolfram T. Knoefel, Susanne Liptay, E. Astudillo, Eugene P. DiMagno, S.A. Sgambati, Werner Inauen, P.C. Bornman, A.M. Wheatley, J.P. Neoptolemos, Peter A. Banks, Jean-Marc Dumonceau, Ulrich Scheurer, Wilker Dk, S. Navarro, F. Largiadèr, Michel Baize, Hans G. Beger, N. Sartori, N. Rilinger, Enrique Domínguez-Muñoz, Ingemar Ihse, Michael W. Müller, C. Bassi, Jan Schmielau, Howard A. Reber, Charles F. Frey, Roland M. Schmid, Larry K. Kvols, Murray Korc, Katsumi Amikura, M.M. Lerch, Hans W. Sollinger, F. Halter, G. Adler, Nicholas R. Lemoine, Kurt G. Grillenberger, Fred Halter, H.-J. Schrag, F. Gansauge, Andrzej S. Tarnawski, Åke Andrén-Sandberg, C. Socci, T. Obeid, Eric P. Krenning, Christian Bloechle, Khalid Al-Sharaf, A. Saenz, Stanislas Pauwels, Christoph E. Broelsch
Publikováno v: Digestive Surgery. 11:I-V
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a81ed1dfb98a2e5c5b548576989db16
https://doi.org/10.1159/000172238
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8
Increased mdm2 expression and immunoreactivity in human pancreatic ductal adenocarcinoma
Autor: Markus W. Büchler, Michael S. Kobrin, M. Ebert, Munehiro Yokoyama, Helmut Friess, Murray Korc
Publikováno v: International journal of oncology. 5(6)
The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bebd30baf01a30caffa091b82c8bfca
https://pubmed.ncbi.nlm.nih.gov/21559710
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10
Cytotoxic effects of TGF-alpha-Pseudomonas exotoxin A fusion protein in human pancreatic carcinoma cells
Autor: Murray Korc, Trang Tran, Rae Lynn Baldwin, Ira Pastan, Michael S. Kobrin
Publikováno v: Pancreas. 13(1)
The epidermal growth factor (EGF) receptor is overexpressed in human pancreatic cancers and cultured cell lines. TP40 is a chimeric protein composed of transforming growth factor-alpha (TGF-alpha) linked to a modified Pseudomonas exotoxin A (PE40) th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575d3ba18dc602a4dbb58a4ba14323e3
https://pubmed.ncbi.nlm.nih.gov/8783329
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