Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael S. G. Clark"'
Publikováno v:
Psychopharmacology. 138:275-282
Sabcomeline, (SB-202026 [R-(Z)-alpha-(methoxyimino)-1 -azabicyclo [2.2.2] octane-3-acetonitrile]), a functionally selective muscarinic M1 receptor partial agonist, was tested in rats trained to perform a delayed, reinforced alternation task in a T ma
Autor:
Frederick Cassidy, Julie Hawkins, Barry Sidney Orlek, Steven Mark Bromidge, Christopher B. Naylor, Frank Brown, Michael S. G. Clark, Loudon Julia Mary, Michael S. Hadley, Graham J. Riley, Steven Dabbs
Publikováno v:
Journal of Medicinal Chemistry. 40:4265-4280
Loss of cholinergic function is believed to be implicated in the cognitive decline associated with senile dementia of the Alzheimer type (SDAT). The disease is characterized by progressive loss of muscarinic receptors located on nerve terminals while
Autor:
Julie Hawkins, Barry Sidney Orlek, Graham J. Riley, Emma J. Collings, Richard E. Faulkner, Frederick Cassidy, Michael S. G. Clark
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1411-1414
Replacement of the ester group in methyl quinuclidine-3-car☐ylate1 with a 1,2,4-triazine ring afforded the high affinity muscarinic partial agonist6a. Analogues7a,7b and7d which incorporate the 1-azabicyclo[2.2.1]heptane ring also display high affi
Autor:
Frederick Cassidy, Richard E. Faulkner, Steven Mark Bromidge, Barry Sidney Orlek, Graham J. Riley, Michael S. G. Clark, Michael S. Hadley, Geoffrey Stemp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1185-1190
Constraining the 1,2,5,6-tetrahydropyridine ring of arecoline 1a and the related muscarinic agonists 1b–e by replacing the N-methyl group by an ethano bridge between the nitrogen and the C5-position afforded compounds 2a–e . These compounds have
Autor:
Barry Sidney Orlek, Graham J. Riley, Richard E. Faulkner, Steven Mark Bromidge, Frank Brown, Michael S. G. Clark, Frederick Cassidy, Loudon Julia Mary, Steven Dabbs, Emma J. Collings
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:557-562
The combination of N-methoxy imidoyl halide and nitrile moieties with the 1,2,5,6-tetrahydropyridine ring system afforded a novel series of potent muscarinic agonists. Members of this class, exemplified by the imidoyl nitriles 2c and 3c , show favour
Autor:
Frank Brown, Steven Mark Bromidge, Graham J. Riley, Emma J. Collings, Loudon Julia Mary, Barry Sidney Orlek, Richard E. Faulkner, Frederick Cassidy, Michael S. G. Clark, Steven Dabbs
Publikováno v:
ChemInform. 25
The combination of N-methoxy imidoyl halide and nitrile moieties with the 1,2,5,6-tetrahydropyridine ring system afforded a novel series of potent muscarinic agonists. Members of this class, exemplified by the imidoyl nitriles 2c and 3c , show favour
Publikováno v:
ChemInform. 26
Autor:
Frederick Cassidy, Michael S. Hadley, Michael S. G. Clark, Geoffrey Stemp, Barry Sidney Orlek, Steven Mark Bromidge, Richard E. Faulkner, Graham J. Riley
Publikováno v:
ChemInform. 25
Constraining the 1,2,5,6-tetrahydropyridine ring of arecoline 1a and the related muscarinic agonists 1b–e by replacing the N-methyl group by an ethano bridge between the nitrogen and the C5-position afforded compounds 2a–e . These compounds have
Autor:
Emma J. Collings, Graham J. Riley, Michael S. G. Clark, Frederick Cassidy, Julie Hawkins, Barry Sidney Orlek, Richard E. Faulkner
Publikováno v:
ChemInform. 25
Replacement of the ester group in methyl quinuclidine-3-car☐ylate1 with a 1,2,4-triazine ring afforded the high affinity muscarinic partial agonist6a. Analogues7a,7b and7d which incorporate the 1-azabicyclo[2.2.1]heptane ring also display high affi
Autor:
Frank Brown, Steven Mark Bromidge, Michael S. G. Clark, Julia M. Loudon, Graham J. Riley, Frederick Cassidy, Steven Dabbs, Barry Sidney Orlek, Michael S. Hadley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:787-790
Replacement of the ester group of methyl quinuclidine-3-carboxylate 2 with an oxime ether afforded a series of potent muscarinic agonists with efficacies ranging from full to partial agonism. From an investigation of the relationship between central