Výsledky vyhledávání - "Michael S. Downey"

Akademický článek

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

Publikováno v: eLife, Vol 11 (2022)

DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A an

Externí odkaz: https://doaj.org/article/57deb83a4c11495681d45121899c60e3

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IRE1α Drives Lung Epithelial Progenitor Dysfunction to Establish a Niche for Pulmonary Fibrosis

Autor: Vincent C. Auyeung, Michael S. Downey, Maike Thamsen, Talia A. Wenger, Bradley J. Backes, Dean Sheppard, Feroz R. Papa

Publikováno v: Am J Physiol Lung Cell Mol Physiol

After lung injury, damage-associated transient progenitors (DATPs) emerge, representing a transitional state between injured epithelial cells and newly regenerated alveoli. DATPs express profibrotic genes, suggesting that they might promote idiopathi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6ca567b10dbdb443a9e6d5321aceae
https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5244

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IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

Autor: Alexis Brumwell, Harold A. Chapman, Vincent C. Auyeung, Feroz R. Papa, Maike Thamsen, Michael S. Downey, Dean Sheppard, Bradley J. Backes, Jaymin J. Kathiriya, Talia A. Wenger

Idiopathic pulmonary fibrosis (IPF) is a disease of progressive interstitial fibrosis, which leads to severe debilitation, respiratory failure, and death. In IPF, environmental exposures interact with genetic risk factors to engender critical patho-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad9c1f7f0f13d4146f65458325184f8
https://doi.org/10.1101/2021.09.16.460705

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Flail Toe Correction: Interpositional Bone Graft and Syndactylization Approaches

Autor: Michael S. Downey

Publikováno v: Hammertoes ISBN: 9783319165516

The flail toe or floppy toe deformity is a condition in which one or more toes of a foot lack stability and structural integrity as the result of excessive bone loss (from surgery, infection, trauma, or tumor) and/or gross motor instability from rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4617bed9bb677eb705ecf2a90ebd846e
https://doi.org/10.1007/978-3-319-16552-3_27

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Autogenous Bone Graft Interpositional Arthrodesis for the Correction of Flail Toe

Autor: K T Mahan, Michael S. Downey, Glenn D. Weinfeld

Publikováno v: Journal of the American Podiatric Medical Association. 93:167-173

Digital surgery is one of the most common types of surgery performed by foot and ankle surgeons. Flail toe is a complication that may occur after overaggressive resection arthroplasty of the proximal interphalangeal joint of the lesser toes. Correcti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c94ac3af5974db5ddde9d9501de883b4
https://doi.org/10.7547/87507315-93-3-167

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Polymicrobial Septic Arthritis Due to Clostridium Species: Case Report and Review

Autor: Michael L. Silverman, Michael S. Downey, Christa M. Gredlein

Publikováno v: Clinical Infectious Diseases. 30:590-594

Clostridium species are capable of producing several types of infectious processes, many of which have proven to be life-threatening. Septic arthritis caused by Clostridium, however, is not a very frequent finding. Currently, only 37 cases of infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7de971a268c070276fc152af3f23b30
https://doi.org/10.1086/313686

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Retrospective analysis of neurapraxia and axonotmesis injuries of select peripheral nerves of the foot and ankle and their conservative and surgical treatment (external neurolysis and neurectomy)

Autor: Howard J. Hillstrom, Michael S. Downey, J. Peter Barrett

Publikováno v: The Journal of Foot and Ankle Surgery. 38:185-193

There is a paucity of scientific literature that has reviewed the conservative and surgical treatment efficacy for the management of injuries causing neurapraxia and axonotmesis. This retrospective study evaluates the clinical outcomes of certain tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd00c2fb8d2c825fdc04d3ede5c0ac41
https://doi.org/10.1016/s1067-2516(99)80051-9

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