Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael S. Donoviel"'
Autor:
Peter Vogel, Michael S Donoviel, Robert Read, Gwenn M Hansen, Jill Hazlewood, Stephen J Anderson, Weimei Sun, Jonathan Swaffield, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4112 (2009)
BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism. Because S1P modulates a wide range of physiological processes, its concentration must be tightly regulated
Externí odkaz:
https://doaj.org/article/7172458c7cd84783a0429e05ecd639e9
Autor:
Alan Wilson, Iris B. Owusu, Boteju Lakmal W, Saadat Aleem, Philip Manton Brown, Jack Yan, Theodore C. Jessop, David J. Augeri, Suman Layek, Zhong Lai, S. David Kimball, Jill Hazelwood, William Heydorn, Kenneth G. Carson, Tamas Oravecz, Liam Moran, Suma Gopinathan, Haiming Zhang, Michael S. Donoviel, Amr Nouraldeen, William K. Sonnenburg, Jeffrey T. Bagdanoff, Jeffrey A. Kramer, Alan Main, Barbara Brooks, Li Dong, James E. Tarver, Padmaja Yalamanchili, Kenny Frazier, Marianne Carlsen, Mark S. Bednarz
Publikováno v:
Journal of Medicinal Chemistry. 53:8650-8662
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in vivo evaluation of synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87e00a9781c267b0a4f8d1324759661
https://doi.org/10.1021/jm101183p
https://doi.org/10.1021/jm101183p
Autor:
Qingyun Liu, Weimei Sun, Amr Nouraldeen, Lawrence F. Courtney, Alan Wilson, Suman Layek, Marianne Carlsen, Sean Yu, Mark S. Bednarz, Zhong Lai, Ann Marie Digeorge-Foushee, Tamas Oravecz, Jerry A. Taylor, Traci Smith, Haiming Zhang, Liam Moran, Jonathan C. Swaffield, Debra Bruce, Jill Hazelwood, Simon D.P. Baugh, David J. Augeri, Emily O’Neill, Joseph Barbosa, Kristen M. Terranova, Suma Gopinathan, Gardyan Michael Walter, Huy Van Nguyen, S. David Kimball, Jeffrey T. Bagdanoff, Jack Yan, Theodore C. Jessop, Michael S. Donoviel, Qinghong Fu, Jeffrey A. Kramer, Alan Main, James E. Tarver, Kenneth G. Carson
Publikováno v:
Journal of Medicinal Chemistry. 52:3941-3953
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL catalyzes the irreversible decomposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb6db472626b33c48fc85b6ff019d0
https://doi.org/10.1021/jm900278w
https://doi.org/10.1021/jm900278w
Autor:
Michael Maceyka, Sarah Spiegel, Tamas Oravecz, Nitai C. Hait, Subramaniam Ramachandran, Sheldon Milstien, Kazuaki Takabe, Michael S. Donoviel
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12)
Sphingosine 1-phosphate (S1P) is a pleiotropic bioactive sphingolipid metabolite that regulates numerous processes important for immune responses. S1P is made within cells and must be transported out of cells to exert its effects through activation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdde1af4f8a829dee4d80b27c4b1571
https://pubmed.ncbi.nlm.nih.gov/26324848
https://pubmed.ncbi.nlm.nih.gov/26324848
Autor:
Jeffrey T, Bagdanoff, Michael S, Donoviel, Amr, Nouraldeen, Marianne, Carlsen, Theodore C, Jessop, James, Tarver, Saadat, Aleem, Li, Dong, Haiming, Zhang, Lakmal, Boteju, Jill, Hazelwood, Jack, Yan, Mark, Bednarz, Suman, Layek, Iris B, Owusu, Suma, Gopinathan, Liam, Moran, Zhong, Lai, Jeff, Kramer, S David, Kimball, Padmaja, Yalamanchili, William E, Heydorn, Kenny S, Frazier, Barbara, Brooks, Philip, Brown, Alan, Wilson, William K, Sonnenburg, Alan, Main, Kenneth G, Carson, Tamas, Oravecz, David J, Augeri
Publikováno v:
Journal of medicinal chemistry. 53(24)
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in vivo evaluation of synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::204bf8f2e5cfe6d6fe7e35186b834e44
https://pubmed.ncbi.nlm.nih.gov/21090716
https://pubmed.ncbi.nlm.nih.gov/21090716
Autor:
Weimei Sun, Gwenn M. Hansen, Tamas Oravecz, Peter Vogel, Michael S. Donoviel, R. Read, Stephen J. Anderson, Jonathan C. Swaffield, Jill Hazlewood
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4112 (2009)
PLoS ONE
PLoS ONE
BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism. Because S1P modulates a wide range of physiological processes, its concentration must be tightly regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe3a756878216394d2804e78bffc0c5
http://europepmc.org/articles/PMC2606024?pdf=render
http://europepmc.org/articles/PMC2606024?pdf=render
Autor:
Kathleen H. Holt, Anne V. Philips, Robert Brommage, Brian Zambrowicz, William J. Paradee, Gwenn M. Hansen, Arthur T. Sands, Christopher M. DaCosta, Adisak Suwanichkul, Deon D. Smith, Derek E. Eberhart, Urvi Desai, David R. Powell, Jean Pierre Revelli, Laura L. Kirkpatrick, Kenneth A. Platt, Kenneth J Coker, Gregory K. Fontenot, Michael R. Kelly, Michael S. Donoviel, Dorit B. Donoviel
Publikováno v:
Obesity (Silver Spring, Md.). 16(10)
We developed a high-throughput approach to knockout (KO) and phenotype mouse orthologs of the 5,000 potential drug targets in the human genome. As part of the phenotypic screen, dual-energy X-ray absorptiometry (DXA) technology estimates body-fat sto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412bccf6fb9bece486a8d3a75661930e
https://pubmed.ncbi.nlm.nih.gov/18719666
https://pubmed.ncbi.nlm.nih.gov/18719666
Autor:
Michael S. Donoviel, Elton T. Young
Publikováno v:
Genetics. 143(3)
Two cis-acting elements have been identified that act synergistically to regulate expression of the glucose-repressed alcohol dehydrogenase 2 (ADH2) gene. UAS1 is bound by the trans-activator Adrlp. UAS2 is thought to be the binding site for an unide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceae8e1230ef00e75594b51fd6b0e489
https://pubmed.ncbi.nlm.nih.gov/8807288
https://pubmed.ncbi.nlm.nih.gov/8807288
Autor:
Michael S. Donoviel, Weimei Sun, Jonathan C. Swaffield, Kenneth G. Carson, Alan Main, Brian Zambrowicz, James Piggott, Qingyun Liu, Arthur T. Sands, S. David Kimball, C. Alexander Turner, David J. Augeri, Stephen J. Anderson, Tamas Oravecz
Publikováno v:
Blood. 110:2292-2292
The ceramide metabolite sphingosine 1-phosphate (S1P) is an important modulator of a wide variety of physiologic functions via its action as a second messenger in intracellular signaling pathways and its extracellular interaction with specific G prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90e340343e47678dcec990315c476c08
https://doi.org/10.1182/blood.v110.11.2292.2292
https://doi.org/10.1182/blood.v110.11.2292.2292
Autor:
Michael S. Donoviel, Brenda J. Andrews
Publikováno v:
Science. 270:251-251
The crystal structure of a heterodimeric transcriptional repressor from yeast, a 1/alpha-2, reported in the same issue of Science , reveals a mechanism for ensuring DNA-binding specificity that may be used by many other DNA-binding heterodimers. B. J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed226239fc88edcb6c7367f149cce31
https://doi.org/10.1126/science.270.5234.251
https://doi.org/10.1126/science.270.5234.251