Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael S. C. Fung"'
Autor:
Nancy T. Chang, Peter Graepel, Jürg Böni, Dietmar G. Braun, Ruey-Shyan Liou, Huldrych F. Günthard, Peter Grob, Michael S. C. Fung, Jörg Schüpbach, Peter L. Gowland, Ruedi Lüthy
Publikováno v:
Europe PubMed Central
A phase I/IIA clinical trial with the chimeric mouse-human monoclonal antibody CGP 47,439 to the principal neutralization determinant in the V3 region of human immunodeficiency virus type 1 (HIV-1) strain IIIB envelope protein gp120 is reported. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f8e62a2a8a8e7fdd58f3ff1633e70e
http://doc.rero.ch/record/299229/files/170-6-1384.pdf
http://doc.rero.ch/record/299229/files/170-6-1384.pdf
Publikováno v:
AIDS Research and Human Retroviruses. 14:205-211
We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the
Autor:
Tse Wen Chang, Wen-I Chang, Michael S. C. Fung, Lee K. Sun, William N. C. Sun, Cecily R. Y. Sun
Publikováno v:
Bio/Technology. 13:779-786
Human hybridoma cell lines secreting IgG specific for the major allergen in the pollen of short ragweed, Amb a I, were established from patients who had been receiving antigen injections for immunotherapy. Recombinant Ig genes were then constructed b
Autor:
Jörg Schüpbach, Tse Wen Chang, Daniel Gygax, Nancy T. Chang, W. Gordon, Huldrych F. Günthard, Dietmar G. Braun, Ruey-Shyan Liou, Luigi Botta, Michael S. C. Fung, Ruedi Lüthy, Peter L. Gowland
Publikováno v:
Biotherapy. 6:205-215
The pharmacokinetics of mouse V/human C (gamma 1, kappa) chimeric monoclonal antibody CGP 47 439 specific for the principal neutralizing determinant of human immunodeficiency virus type 1 (HIV-1) was studied in patients with stage IV HIV-1 disease in
Autor:
Richard A. Koup, Tse Wen Chang, Michael S. C. Fung, William N.C. Sun, Jeffrey T. Safrit, Charla Andrews, Dietmar G. Braun
Publikováno v:
AIDS. 7:15-22
To determine whether passive transfer of a monoclonal antibody specific for the principal neutralizing determinant in the V3 region of HIV-1IIIB gp120 can protect mice with severe combined immunodeficiency (SCID) transplanted with normal human periph
Autor:
Wayne Gordon, Tse Wen Chang, Michael S. C. Fung, Walter Bee, Luigi Botta, Fred Gudat, Dietmar G. Braun, Ruey-Shyan Liou, Nancy T. Chang, Ulrich Zühlke, Sam McKinney, Daniel Gygax
Publikováno v:
Biotherapy. 5:291-299
In preparing for testing a pharmaceutical grade preparation of chimeric (mouse/human) antibody CGP 47,439 in HIV-1 infected individuals, it was administered to Macaca fascicularis (cynomolgus) monkeys to study tolerability, immunogenicity and pharmac
Publikováno v:
The Journal of infectious diseases. 171(5)
Monoclonal antibody BAT123 was passively transferred into SCID mice reconstituted with human peripheral blood lymphocytes (hu-PBL-SCID) to study passive antibody protection against human immunodeficiency virus type 1 (HIV-1) infection. BAT123 is spec
Publikováno v:
AIDS research and human retroviruses. 8(8)
Autor:
Tse Wen Chang, Cecily Sun, Michael S. C. Fung, David D. Ho, Yunzhen Cao, Xi Ling Li, Nai-Chau Sun
To define the domains in the envelope glycoprotein important for antibody neutralization of the human immunodeficiency virus type 1 (HIV-1), monoclonal antibodies (mAbs) were generated by immunizing mice with purified glycoprotein gp120 of the IIIB i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2accc23c4339a38ff334b4f63507772
https://europepmc.org/articles/PMC52628/
https://europepmc.org/articles/PMC52628/
Publikováno v:
Nature Biotechnology. 5:940-946
Several hybridomas secreting neutralizing monoclonal antibodies against the AIDS virus, human immunodeficiency virus type 1 (HIV–1), have been developed by immunizing mice with inactivated HIV–1 and fusing the immune spleen cells with myeloma cel