Výsledky vyhledávání - "Michael S. Bohnen"

Akademický článek

Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension

Autor: Gabriel Redel-Traub, Kevin J. Sampson, Robert S. Kass, Michael S. Bohnen

Publikováno v: Biomolecules, Vol 12, Iss 10, p 1341 (2022)

Pulmonary arterial hypertension (PAH) is a devastating disease with high morbidity and mortality. Deleterious remodeling in the pulmonary arterial system leads to irreversible arterial constriction and elevated pulmonary arterial pressures, right hea

Externí odkaz: https://doaj.org/article/6d3c1f4ca390417098685e0b3f9e7c09

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery

Autor: Michael S. Bohnen, Danilo Roman‐Campos, Cecile Terrenoire, Jack Jnani, Kevin J. Sampson, Wendy K. Chung, Robert S. Kass

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 9 (2017)

BackgroundHeterozygous loss of function mutations in the KCNK3 gene cause hereditary pulmonary arterial hypertension (PAH). KCNK3 encodes an acid‐sensitive potassium channel, which contributes to the resting potential of human pulmonary artery smoo

Externí odkaz: https://doaj.org/article/32882c0141664ad9848b413aef312526

Zobrazit plný text záznamu

A Wrong Turn

Autor: Michael S. Bohnen, Brahmajee K. Nallamothu, Robert Zilinyi, Sanjay Saint, Emily D. Slater

Publikováno v: New England Journal of Medicine. 388:2087-2093

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d5743e271a29f55038e76005befed38
https://doi.org/10.1056/nejmcps2215388

Zobrazit plný text záznamu

Advanced heart failure patients supported with ambulatory inotropic therapy: What defines success of therapy?

Autor: Michael S. Bohnen, Hasan Garan, Veli K. Topkara, Nir Uriel, Christopher S. Grubb, Paolo C. Colombo, Ersilia M. DeFilippis, Shunichi Nakagawa, Gabriel Sayer, Jennifer Haythe, Maryjane Farr, Lauren K. Truby, Yoshifumi Naka, Kelly Axsom, Koji Takeda, Melana Yuzefpolskaya, A. Kleet

Publikováno v: American Heart Journal. 239:11-18

Objective The objective of this study was to describe the profiles and outcomes of a cohort of advanced heart failure patients on ambulatory inotropic therapy (AIT). Background With the growing burden of patients with end-stage heart failure, AIT is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a30118701383cee25254fb109df660
https://doi.org/10.1016/j.ahj.2021.05.001

Zobrazit plný text záznamu

Molecular Pathophysiology of Congenital Long QT Syndrome

Autor: Michael S. Bohnen, Kevin J. Sampson, Robert S. Kass, Vivek Iyer, Seth Robey, Cecile Terrenoire, G. Peng

Publikováno v: Physiological Reviews. 97:89-134

Ion channels represent the molecular entities that give rise to the cardiac action potential, the fundamental cellular electrical event in the heart. The concerted function of these channels leads to normal cyclical excitation and resultant contracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046c7f3be3f200f540a22a3c1c50e2c8
https://doi.org/10.1152/physrev.00008.2016

Zobrazit plný text záznamu

CASE OF THE PINK CELLS: A RARE CAUSE OF ACUTE SHOCK IN CHRONIC HEART FAILURE

Autor: Michael S. Bohnen, Sun Hi Lee, Markus D. Siegelin, Kelly Axsom, Claudio A Bravo, Robert Zilinyi, Ryan Lahey

Publikováno v: Journal of the American College of Cardiology. 75:3355

Eosinophilic myocarditis (EM) is a rare, rapidly progressive and often fatal cause of acute heart failure. A 66 year-old male with eosinophilic pneumonia and chronic systolic heart failure presented with elevated troponin and peripheral eosinophilia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8151f8daf4cfb40f1400bb4dc5d3197d
https://doi.org/10.1016/s0735-1097(20)33982-6

Zobrazit plný text záznamu

Loss of Function ABCC8 Mutations in Pulmonary Arterial Hypertension

Autor: Michael S. Bohnen, Charaka Hadinnapola, Joanna Pepke-Zaba, Anton Vonk Noordegraaf, David G. Kiely, Stephen J. Wort, Andrew J. Peacock, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Erika B. Rosenzweig, Frederick E. Dewey, Wendy K. Chung, Kevin J. Sampson, Mélanie Eyries, Paul A. Corris, Robert S. Kass, Lijiang Ma, Allan Lawrie, Yufeng Shen, Colin G. Nichols, Mark Toshner, Katherine Yates, Jeffrey G. Reid, Christophe Guignabert, Matthias Haimel, J. Simon R. Gibbs, Gerry Coghlan, Marc Humbert, John D. Overton, Harm Jan Bogaard, Arjan C. Houweling, Colin Church, Jennifer M. Martin, Robert V. MacKenzie Ross, Stefan Gräf, Barbara Girerd, Martin R. Wilkins, John Wharton, David Montani, Na Zhu, Marta Bleda, Aris Baras, Florent Soubrier, Conor McClenaghan, Nicholas W. Morrell, Usha Krishnan, Hongjian Qi, Jay Suntharalingam, Richard C. Trembath, Carmen M. Treacy

Publikováno v: Circulation. Genomic and precision medicine, 11(10). Lippincott Williams and Wilkins Ltd.
Bohnen, M S, Ma, L, Zhu, N, Qi, H, McClenaghan, C, Gonzaga-Jauregui, C, Dewey, F E, Overton, J D, Reid, J G, Shuldiner, A R, Baras, A, Sampson, K J, Bleda, M, Hadinnapola, C, Haimel, M, Bogaard, H J, Church, C, Coghlan, G, Corris, P A, Eyries, M L, Gibbs, J S R, Girerd, B, Houweling, A C, Humbert, M, Guignabert, C, Kiely, D G, Lawrie, A, MacKenzie Ross, R V, Martin, J M, Montani, D, Peacock, A J, Pepke-Zaba, J, Soubrier, F, Suntharalingam, J, Toshner, M, Treacy, C M, Trembath, R C, Vonk Noordegraaf, A, Wharton, J, Wilkins, M R, Wort, S J, Yates, K, Gräf, S, Morrell, N W, Krishnan, U, Rosenzweig, E B, Shen, Y, Nichols, C G, Kass, R S & Chung, W K 2018, ' Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension ', Circulation. Genomic and precision medicine, vol. 11, no. 10, pp. e002087 . https://doi.org/10.1161/CIRCGEN.118.002087

Background: In pulmonary arterial hypertension (PAH), pathological changes in pulmonary arterioles progressively raise pulmonary artery pressure and increase pulmonary vascular resistance, leading to right heart failure and high mortality rates. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfaae7efe5801390209c44868e91dfa5
https://europepmc.org/articles/PMC6206877/

Zobrazit plný text záznamu

The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery

Autor: Wendy K. Chung, Kevin J. Sampson, Cecile Terrenoire, Robert S. Kass, Michael S. Bohnen, Danilo Roman-Campos, Jack Jnani

Publikováno v: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Heterozygous loss of function mutations in the KCNK 3 gene cause hereditary pulmonary arterial hypertension ( PAH ). KCNK 3 encodes an acid‐sensitive potassium channel, which contributes to the resting potential of human pulmonary artery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47696ff8fbf280d9d19c5e6b117c8919
https://doi.org/10.1161/jaha.117.006465

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání