Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Michael S. Bernatowicz"'
Autor:
Claudio Mapelli, Ramakrishna Seethala, Songping Han, Ellen Sieber-McMaster, William R. Ewing, Ashish Khanna, Keith L. Constantine, Douglas James Riexinger, Daniel Longhi, John Krupinski, Zhengping Ma, Constance Smith-Monroy, Bastos Margarita M, Dan Shi, Michael S. Bernatowicz, Joseph R. Taylor, Christine Huang, Rajasree Golla, Gordon William Robinson, Jelka Pluscec, Jean M. Whaley, Sesha Natarajan, Jean-Philippe Meyer, Robert H. Stoffel, Li Xin, Ving G. Lee, Barry Koplowitz, Cecilia L Chi, Ildiko Antal-Zimanyi
Publikováno v:
Journal of Medicinal Chemistry. 52:7788-7799
Glucagon-like peptide 1 (GLP-1) is a 30 or 31 amino acid peptide hormone that contributes to the physiological regulation of glucose homeostasis and food intake. Herein, we report the discovery of a novel class of 11 amino acid GLP-1 receptor agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59d43fbd51aab4facd89ceaa788aab6
https://doi.org/10.1021/jm900752a
https://doi.org/10.1021/jm900752a
Publikováno v:
International Journal of Peptide and Protein Research. 28:107-112
The 3-nitro-2-pyridinesulfenyl (Npys) derivative of cysteine was prepared and used to facilitate the formation of an unsymmetrical disulfide bond. Since this derivative is stable in trifluoroacetic acid:CH2 Cl2 (1:1) and anhydrous hydrogen fluoride,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ae202fa67502cf0d5ccb2670bdeaf1
https://doi.org/10.1111/j.1399-3011.1986.tb03236.x
https://doi.org/10.1111/j.1399-3011.1986.tb03236.x
Publikováno v:
The Journal of Organic Chemistry. 59:6687-6691
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd31bc2affd8facfab9da798b29ccfbe
https://doi.org/10.1021/jo00101a029
https://doi.org/10.1021/jo00101a029
Publikováno v:
Journal of the American Chemical Society. 116:1746-1752
Tryptophan alkylation by resin-derived carbocations and formation of diketopiperazine are two major yield reducing side reactions observed in Fmoc/t-Bu based solid-phase peptide synthesis. With the development of a versatile silicon-based linkage age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d8424f8b852cd49317c8fd4c0c41b0
https://doi.org/10.1021/ja00084a016
https://doi.org/10.1021/ja00084a016
Publikováno v:
Synthetic Communications. 23:3055-3060
Fmoc-Argw, w′(Boc)2-OH and Boc-Argw, w′(Cbz)2-OH were prepared in two steps: Guanylation of Cu(II)-ornithine complex at Nδ with N, N′bis-urethane protected derivatives of 1-guanylpyrazole, followed by Nα-protection using either 9-fluorenylmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e46005b8bc98339722300ca9488913
https://doi.org/10.1080/00397919308011149
https://doi.org/10.1080/00397919308011149
Publikováno v:
Tetrahedron Letters. 34:3377-3380
A new phosphitylating agent, compatible with the Fmoc/t-butyl strategy for the production of phosphotyrosine containing peptides was synthesized. Our results demonstrated that high yields and high purities of phosphotyrosine peptides can be obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::898473703547ad4b4133cd478ef79b7f
https://doi.org/10.1016/s0040-4039(00)79160-x
https://doi.org/10.1016/s0040-4039(00)79160-x
Publikováno v:
Tetrahedron Letters. 34:3389-3392
Bis-urethane protected derivatives of 1-guanylpyrazole were prepared and found to readily react with relatively amines at room temperature to produce bis-protected guanidines in good yields. Simultaneous removal of both protecting groups from these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::832f6a7c34063416c0a2a9e2d971bb6c
https://doi.org/10.1016/s0040-4039(00)79163-5
https://doi.org/10.1016/s0040-4039(00)79163-5
Publikováno v:
The Journal of Organic Chemistry. 58:2640-2644
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3336328f896075f5f8b963bfbe7818e7
https://doi.org/10.1021/jo00061a049
https://doi.org/10.1021/jo00061a049
Publikováno v:
Synthetic Communications. 23:657-661
A novel, more efficient and practical synthesis of the title compound, recently reported as a potent inhibitor of nitric oxide synthase is described. Reaction of (L)-ornithine with 1H-pyrazole-N-allyl-1-carboxamidine allowed facile isolation of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8542eae0fdc2fad4576987768c323a75
https://doi.org/10.1080/00397919308009824
https://doi.org/10.1080/00397919308009824
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e01d79c2d5341f05180475b29331769
https://doi.org/10.1002/chin.199234280
https://doi.org/10.1002/chin.199234280