Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael S-S Su"'
Autor:
Charles A. Dinarello, Sandra Grès, Catherine Farnarier, Michael S.-S. Su, Valérie Marin, Gilles Kaplanski, Solange Kaplanski
Publikováno v:
Blood. 98:667-673
Thrombin, the terminal serine protease in the coagulation cascade, is a proinflammatory molecule in vivo and induces endothelial activation in vitro. The cellular signaling mechanisms involved in this function are unknown. The role of the p38 mitogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3ea8e064fe4cd6cd18d014f61c7fb7
https://doi.org/10.1182/blood.v98.3.667
https://doi.org/10.1182/blood.v98.3.667
Autor:
Francesco G. Salituro, Ursula A. Germann, Keith P. Wilson, Guy W. Bemis, Ted Fox, Michael S.-S. Su
Publikováno v:
Current Medicinal Chemistry. 6:807-823
p38 MAP kinase is a member of the family of kinases which mediate intracellular transduction pathways. The activation of this particular MAP kinase pathway is in response to a broad variety of extracellular stimuli. Subsequent downstream events trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1e79bcba54a12326ce6a328d79e8c7
https://doi.org/10.2174/092986730609220401150415
https://doi.org/10.2174/092986730609220401150415
Autor:
Michael S.-S. Su, Pamella J. Ford, Joyce T. Coll, Xiaoling Xie, Mark A. Fleming, Ursula A. Germann, Margaret D. Porter, Ted Fox, S. Pazhanisamy, Wilson Keith P, Vincent Galullo
Publikováno v:
Protein Science. 7:2249-2255
Mitogen-activated protein (MAP) kinases are serine/threonine kinases that mediate intracellular signal transduction pathways. Pyridinyl imidazole compounds block pro-inflammatory cytokine production and are specific p38 kinase inhibitors. ERK2 is rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37641d7d3204292ae2056bd27d2e57de
https://doi.org/10.1002/pro.5560071102
https://doi.org/10.1002/pro.5560071102
Autor:
Mark A. Fleming, William Markland, Yong Gu, Joyce T. Coll, Paul R. Caron, Wilson Keith P, Ted Fox, Xiaoling Xie, Michael S-S Su
Publikováno v:
Structure. 6(8):983-991
Background: The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. Activation and nuclear localization of JNK3, a neuronal-specific i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58a6f1538ecefa95325b44908c9920e
Autor:
Hajime Karasuyama, Yong Gu, Tarik F. Haydar, Pasko Rakic, Michael S.-S. Su, Chia-Yi Kuan, Keisuke Kuida, Richard A. Flavell, Choji Taya
Publikováno v:
Cell. 94:325-337
Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a critical upstream activator of caspases through gene targeting in mice. The majority of Casp9 knockout mice die perinatal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d22d7630d8567228299ad2a00d3fa3
https://doi.org/10.1016/s0092-8674(00)81476-2
https://doi.org/10.1016/s0092-8674(00)81476-2
Autor:
Thomas Mandrup-Poulsen, Michael S.-S. Su, Leland Shapiro, Allan E. Karlsen, Lone F. Juhl, Claus M. Larsen, Charles A. Dinarello, Henrik U. Andersen, Karin Wadt, Klaus Seedorf
Publikováno v:
Journal of Biological Chemistry. 273:15294-15300
Interleukin-1beta (IL-1beta) is cytotoxic to rat pancreatic beta-cells by inhibiting glucose oxidation, causing DNA damage and inducing apoptosis. Nitric oxide (NO) is a necessary but not sufficient mediator of these effects. IL-1beta induced kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288670218f4362f2eb9b3de48d33e0ea
https://doi.org/10.1074/jbc.273.24.15294
https://doi.org/10.1074/jbc.273.24.15294
Publikováno v:
Blood. 90:2075-2083
The short-chain fatty acid butyrate has been shown to elevate fetal hemoglobin (HbF ) by inducing expression of the γ-globin gene. Regulation of gene expression by butyrate is thought to proceed via inhibition of the enzyme histone deacetylase, lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1793e2d8f58beb6b558cb5e0ec56e125
https://doi.org/10.1182/blood.v90.5.2075
https://doi.org/10.1182/blood.v90.5.2075
Publikováno v:
Journal of Virology. 71:6465-6471
Hepatitis C virus encodes a large polyprotein precursor that is proteolytically processed into at least 10 distinct products, in the order NH2-C-E1-E2-p7-NS2-NS3-NS4A-NS4B-NS5A-NS5B -COOH. A serine proteinase encoded in the N-terminal 181 residues of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0b8356f1883d2293a5973e49c75a6a
https://doi.org/10.1128/jvi.71.9.6465-6471.1997
https://doi.org/10.1128/jvi.71.9.6465-6471.1997
Publikováno v:
Molecular and Cellular Biology. 17:2360-2371
The transcription factors Elk-1 and SAP-1 bind together with serum response factor to the serum response element present in the c-fos promoter and mediate increased gene expression. The ERK, JNK, and p38 groups of mitogen-activated protein (MAP) kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244189b07e4f21f9208f7fd7188117d8
https://doi.org/10.1128/mcb.17.5.2360
https://doi.org/10.1128/mcb.17.5.2360
Autor:
James P. Griffith, Michael S.-S. Su, Paul R. Caron, Stephen P. Chambers, Matthew J. Fitzgibbon, Wenyong Chen, Wilson Keith P, Patricia G. McCaffrey
Publikováno v:
Journal of Biological Chemistry. 271:27696-27700
p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses. The crystal structure of the apo, unphosphorylated form of p38 kinase has been solved a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4d04f49f0551ca46aeae941e390859
https://doi.org/10.1074/jbc.271.44.27696
https://doi.org/10.1074/jbc.271.44.27696