Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Michael S Wertheim"'
Autor:
Alexander Spira, Michael S Wertheim, Edward J Kim, Benjamin Tan, Heinz-Josef Lenz, Petros Nikolinakos, Patricia L Rich, Genevieve Jehl, Andreas Machl, Rena Ito, James L Gulley, Scott Kopetz
Publikováno v:
The oncologist, vol 28, iss 2
Colorectal cancer (CRC) is a heterogeneous and complex disease with limited treatment options. Targeting transforming growth factor β (TGF-β) and programmed death ligand 1 pathways may enhance antitumor efficacy. Bintrafusp alfa is a first-in-class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d6403e7262c76cbeb055a90d5d8f38
https://pubmed.ncbi.nlm.nih.gov/36576431
https://pubmed.ncbi.nlm.nih.gov/36576431
Autor:
Fitzroy Dawkins, Andres Forero-Torres, William Jeffery Edenfield, Justin Call, Li Zhou, Daniel O. Persky, Paolo Caimi, Xuejun Chen, Swaminathan P. Iyer, Carolina Escobar, Abdulraheem Yacoub, Michael S. Wertheim, Douglas J DeMarini, Radhakrishnan Ramchandren, Martin Gutierrez, Luke P. Akard, Tycel Phillips
This phase 1/2 study assessed parsaclisib (INCB050465), a next-generation, potent, and highly selective phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor, in patients with relapsed or refractory B-cell malignancies, alone or in combination with a J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcecfa88ad0f4c321ee1122db18dc82d
https://europepmc.org/articles/PMC6543513/
https://europepmc.org/articles/PMC6543513/
Autor:
Jiping Zha, Rodryg Ramlau, J. Goldschmidt, David R. Spigel, Maciej Krzakowski, Benoit Godbert, Gilles Robinet, Michael S. Wertheim, George R. Blumenschein, Thomas Ervin, Robert L. Yauch, Premal Patel, Fabrice Barlesi, Ramaswamy Govindan, Wei Yu, Sergey Orlov, Amy C. Peterson, Taral Patel, See Chun Phan, Davey B. Daniel
Publikováno v:
Journal of Clinical Oncology. 31:4105-4114
Purpose Increased hepatocyte growth factor/MET signaling is associated with poor prognosis and acquired resistance to epidermal growth factor receptor (EGFR) –targeted drugs in patients with non–small-cell lung cancer (NSCLC). We investigated whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3024fb24b642f42b1d3093fde13e00d
https://doi.org/10.1200/jco.2012.47.4189
https://doi.org/10.1200/jco.2012.47.4189
Autor:
Paula W. Annunziato, Donald M. Poretz, Michael R. Mullane, Jon E. Stek, Michael S. Wertheim, Tina M. Sterling, Yanli Zhao, Steven A. Pergam, Drew J. Winston, Susan B. Manoff, Luis H. Camacho, Kathleen M. Mullane, Robert F. Betts
Publikováno v:
The Journal of Infectious Diseases. 208:1375-1385
BACKGROUND Safety and immunogenicity of heat-treated zoster vaccine (ZVHT) were assessed in immunocompromised adults. METHODS In a randomized, double-blind, placebo-controlled, multicenter study, 4 doses ZVHT or placebo were administered approximatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97050cdd1620224f7df2fd47a78eb8c1
https://doi.org/10.1093/infdis/jit344
https://doi.org/10.1093/infdis/jit344
Autor:
Thomas A. Hensing, Raymond Thertulien, Ravi Salgia, Frank A. Scappaticci, David R. Gandara, Rajendra S. Pradhan, Dawn M. Carlson, Nasser H. Hanna, Jiang Qian, Glenwood D. Goss, James Chih-Hsin Yang, Benjamin Besse, Ross A. Soo, Christa Lee, J. L. Ricker, Michael S. Wertheim, Eng Huat Tan, Neeraj Gupta, Julien Mazieres, Qin Qin
Publikováno v:
Journal of Thoracic Oncology. 6(8):1418-1425
Introduction This study assessed activity and safety of linifanib (ABT-869), a selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptors, in patients with locally advanced or metastatic non-small cell lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ffd67fbb8197c609949ab788169233
Autor:
Stanislav Spelda, Andrew Coates, Barry L. Dowell, Andrew Krivoshik, Jane Qian, Peter Ansell, Xiangdong Zhou, Gary S. Gordon, Rajendra S. Pradhan, Ann M. Mauer, Martin Šmakal, Evelyn McKeegan, Rosalyn A. Juergens, Charles M. Rudin, Michael S. Wertheim
Publikováno v:
Journal of Clinical Oncology. 29:1075-1082
Purpose ABT-751 is an antimitotic and vascular disrupting agent with potent preclinical anticancer activity. We conducted a phase I and randomized double-blind phase II study of pemetrexed with ABT-751 or placebo in patients with recurrent advanced o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92882bc9bc37b39ddf5c47974e8889d2
https://doi.org/10.1200/jco.2010.32.5944
https://doi.org/10.1200/jco.2010.32.5944
Autor:
Thomas E. Jackson, Michael S. Wertheim, Paul G. D. Spry, John M Sparrow, Adam H. Ross, Jeremy P. Diamond
Publikováno v:
European Journal of Ophthalmology. 21:400-403
Purpose TO compare the diurnal intraocular pressure (IOP) profile pre and post trabeculectomy with a control group of medically controlled patients. We compared the change in mean, peak, and diurnal IOP fluctuation. Methods This was an observational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bdc0ff68f2419b7be2c020a2e2c1ad
https://doi.org/10.5301/ejo.2010.5821
https://doi.org/10.5301/ejo.2010.5821
Autor:
Michael S. Wertheim, Petros Nikolinakos, Isabelle Dussault, Benjamin R. Tan, Edward J. Kim, Christoph Helwig, Patricia Rich, Heinz-Josef Lenz, Scott Kopetz, James L. Gulley, David Smith, Alexander I. Spira, Laureen S. Ojalvo
Publikováno v:
Journal of Clinical Oncology. 36:764-764
764 Background: Inhibiting the transforming growth factor β (TGF-β) pathway, which plays a key role in tumor immunosuppression, may enhance the response to programmed death 1/programmed death ligand 1 (PD-1/PD-L1) monoclonal antibodies (mAbs). M782
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79e2265166d437a3573ab15a16900902
https://doi.org/10.1200/jco.2018.36.4_suppl.764
https://doi.org/10.1200/jco.2018.36.4_suppl.764
Autor:
Jean P. O'Malley, William D. Mathers, Michael S. Wertheim, F. Mackensen, Angela S. Watkins, Lyndell L Lim, James T. Rosenbaum
Publikováno v:
Ocular Immunology and Inflammation. 14:203-206
To explore the use of in-vivo confocal microscopy (IVCM) as a potential non-invasive adjunctive tool for diagnosing sarcoidosis.Conjunctivae were imaged using confocal microscopy in 10 patients with sarcoidosis and 27 control subjects. We utilized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095ce07c951bdd06c91146c69e6bfa76
https://doi.org/10.1080/09273940600826471
https://doi.org/10.1080/09273940600826471
Autor:
Théa Faivre, Tycel Phillips, Andres Forero-Torres, William Jeffery Edenfield, Michael S. Wertheim, Harry Miao, Jennifer Pulini, Matt Spear, Swamy Yeleswaram, Rod Ramchandren, Li Zhou, Martin Gutierrez, Maureen Bleam
Publikováno v:
Cancer Research. 76:CT056-CT056
Background: PI3Kδ inhibitors have demonstrated efficacy in the treatment of B-cell malignancies, but off-target toxicity and/or the inability to achieve near-complete inhibition of the PI3Kδ pathway may affect the depth and duration of response. IN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326706787442d8f949e98552de69e8f5
https://doi.org/10.1158/1538-7445.am2016-ct056
https://doi.org/10.1158/1538-7445.am2016-ct056