Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Michael S Scherman"'
Autor:
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87909 (2014)
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB baci
Externí odkaz:
https://doaj.org/article/5a17b56fb20942aa854494bae86ab371
Autor:
Charles S. Henry, Michael S. Scherman, Yosita Panraksa, James S. Terry, Zachary Call, Jeremy Link, Brian J. Geiss, David S. Dandy, Ilhoon Jang, Cody S. Carrell
A disposable enzyme-linked immunosorbent assay (dELISA) device for ate-home or doctor’s office use was developed to detect SARS-CoV-2 antibodies. Serology testing for SARS-CoV-2 antibodies is currently run using well-plate ELISAs in centralized lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5411b65ce2261a80a86a0889cdc5e4ae
https://doi.org/10.26434/chemrxiv-2021-c4bmd-v3
https://doi.org/10.26434/chemrxiv-2021-c4bmd-v3
Autor:
Gregory T. Robertson, Pradeep B. Lukka, Chetan Rathi, Anne J. Lenaerts, Zaid H. Temrikar, Bernd Meibohm, Michael S. Scherman, Keyur Parmar, Santosh Wagh, Jiuyu Liu, Richard E. Lee
Publikováno v:
Antimicrob Agents Chemother
Despite decades of research, tuberculosis remains a leading cause of death from a single infectious agent. Spectinamides are a promising novel class of antituberculosis agents, and the lead spectinamide 1810 has demonstrated excellent efficacy, safet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe9d5488e98eb4793e78bb952f24af
https://pubmed.ncbi.nlm.nih.gov/34424046
https://pubmed.ncbi.nlm.nih.gov/34424046
Autor:
James S. Terry, Tony Schountz, Carley McAlister, Brian J. Geiss, Rushika Perera, Michael S. Scherman, Loran Br. Anderson
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Virology
article-version (status) pre
article-version (number) 1
Virology
To help fight COVID-19, new molecular tools specifically targeting critical components of the causative agent of COVID-19, SARS-Coronavirus-2 (SARS-CoV-2), are desperately needed. The SARS-CoV-2 nucleocapsid protein is critical for viral replication,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fa5bd417e1ed439630d51c005ada18
http://europepmc.org/articles/PMC7480041
http://europepmc.org/articles/PMC7480041
Autor:
Jason Halladay, Tanya Parish, Wai Choi, Vincent Hernandez, Anne J. Lenaerts, Anthony J. Smith, Matthew B. McNeil, Gregory T. Robertson, Victoria A. Ektnitphong, Michael S. Scherman, Pamela Berry, Weimin Mao, Aaron Korkegian, Devon Dennison, Yi Xia, Yasheen Zhou, David S. Carter, M. R. K. Alley
Publikováno v:
Antimicrobial Agents and Chemotherapy
AN12855 is a direct, cofactor-independent inhibitor of InhA in Mycobacterium tuberculosis. In the C3HeB/FeJ mouse model with caseous necrotic lung lesions, AN12855 proved efficacious with a significantly lower resistance frequency than isoniazid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f207338121273b5a491c232cb556c368
https://doi.org/10.1128/aac.02071-18
https://doi.org/10.1128/aac.02071-18
Autor:
Pamela Berry, Yasheen Zhou, David S. Carter, Jason Halladay, Courtney Hastings, Vincent Hernandez, Bjorn Sunde, Weimin Mao, James C. Sacchettini, Aaron Korkegian, Wai Choi, Peter J. Tonge, Mrk Alley, Anne J. Lenaerts, Yi Xia, Gregory T. Robertson, Michael S. Scherman, Tanya Parish, Lisa K. Woolhiser, Veronica Gruppo, Lindsay Flint, Thomas R. Ioerger, Theresa O’Malley, Matthew B. McNeil
Publikováno v:
Life Science Alliance
AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis, good oral bioavailability, and comparable efficacy to isoniazid in infection models.
New antitubercular ag
New antitubercular ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b771f3e73b484f275174c0822eeecdd9
http://europepmc.org/articles/PMC6238539
http://europepmc.org/articles/PMC6238539
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Autor:
Julian G. Hurdle, Rashid Akbergenov, Cristina Villellas, José A. Aínsa, Michael R. McNeil, Robin B. Lee, Jiuyu Liu, Dora B. Madhura, Erik C. Böttger, Rakesh, Zhong Zheng, Richard E. Lee, Bernd Meibohm, Pavan K. Vaddady, Jianjun Qi, Sourav Das, Samanthi L. Waidyarachchi, David F. Bruhn, Helena I. Boshoff, Michael S. Scherman, Dianqing Sun, Mercedes Gonzalez-Juarrero, Tanja Matt, Chetan Rathi, Anne J. Lenaerts, Ashit Trivedi
Publikováno v:
Nature medicine
Although the classical antibiotic spectinomycin is a potent bacterial protein synthesis inhibitor, poor antimycobacterial activity limits its clinical application for treating tuberculosis. Using structure-based design, we generated a new semisynthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396f54db42daeebac88aa11700c39d12
https://doi.org/10.1038/nm.3458
https://doi.org/10.1038/nm.3458
Autor:
Victoria Jones, Mary Jackson, Marcus M. Maddox, Anna E. Grzegorzewicz, Christophe Morisseau, E. Jeffrey North, Michael R. McNeil, David F. Bruhn, Tamara Hess, Jerrod S. Scarborough, Richard E. Lee, Michael S. Scherman, Lei Yang
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2587-2599
Out of the prominent global ailments, tuberculosis (TB) is still one of the leading causes of death worldwide due to infectious disease. Development of new drugs that shorten the current tuberculosis treatment time and have activity against drug resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff5d124a69bf8a2f42fef4079b74623
https://doi.org/10.1016/j.bmc.2013.02.028
https://doi.org/10.1016/j.bmc.2013.02.028
Autor:
Marko Maringer, Mary Gardiner, Wulf Oehlmann, Lisa Pirrie, Wassila Abdelli Boulkeroua, Ruth Brenk, Leah S. Torrie, Nicholas J. Westwood, Michael S. Scherman, Robert A. Field, Mahavir Singh, Aurijit Sarkar, Michael R. McNeil, James H. Naismith, David W. Gray, Magnus S. Alphey, Martin Rejzek
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology; Vol 8
ACS Chemical Biology; Vol 8
Glucose-1-phosphate thymidylyltransferase (RmlA) catalyzes the condensation of glucose-1-phosphate (G1P) with deoxy-thymidine triphosphate (dTTP) to yield dTDP-d-glucose and pyrophosphate. This is the first step in the l-rhamnose biosynthetic pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c20f6ed0f58f102bfaec1f8823af09
Autor:
Ashit Trivedi, Bernd Meibohm, David F. Bruhn, Michael R. McNeil, Marcus M. Maddox, Michael S. Scherman, Rakesh, Dora B. Madhura, Lei Yang, Robin B. Lee, Anne J. Lenaerts, Richard E. Lee, Janet C. Gilliland, Veronica Gruppo
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6063-6072
A series of tetracyclic nitrofuran isoxazoline anti-tuberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent anti-tuberculosis activity but suffered from poor solubility,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774b8ff1cb144c294974a0c3a34bb7c9
https://doi.org/10.1016/j.bmc.2012.08.023
https://doi.org/10.1016/j.bmc.2012.08.023