Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michael S Pegg"'
Autor:
Wen-Yang Wu, Hume Forrest White, Mark von Itzstein, Gaik B. Kok, Jeffrey Clifford Dyason, Michael S. Pegg, Stuart W. Oliver
Publikováno v:
Journal of Medicinal Chemistry. 39:388-391
The development of sialidase inhibitor-based potential anti-influenza drugs using rational drug design techniques has been of recent interest. The present study details an investigation of the active site of influenza virus sialidase by using the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f03e870f167b50bfc226754656aaf9a
https://doi.org/10.1021/jm950294c
https://doi.org/10.1021/jm950294c
Publikováno v:
European Journal of Biochemistry. 207:335-343
The enzyme mechanism of sialidase from influenza virus has been investigated by kinetic isotope methods, NMR, and a molecular dynamics simulation of the enzyme-substrate complex. Comparison of the reaction rates obtained with the synthetic substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35079f30c434612d7c97df50df7ba236
https://doi.org/10.1111/j.1432-1033.1992.tb17055.x
https://doi.org/10.1111/j.1432-1033.1992.tb17055.x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1077:65-71
Ca 2+ increases the initial rate of activity of sialidase from influenza virus (A/Tokyo/3/67). Increasing ionic strength also activates influenza virus sialidase. When ionic strength is controlled, smaller but still significant Ca 2+ effects are obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38107217e987835e818a7d1df4d3b4d7
https://doi.org/10.1016/0167-4838(91)90526-6
https://doi.org/10.1016/0167-4838(91)90526-6
Autor:
Michael S Pegg
EDITOR—In their article on overcoming barriers to recruitment in health research Hewison and Haines imply that all research ethics committees require that only patients who “opt in” after receiving a communication from a researcher can be inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87b93f6570440ec8e2fd7eb8888989f
https://europepmc.org/articles/PMC1550442/
https://europepmc.org/articles/PMC1550442/
Publikováno v:
FEBS Letters. 372:148-150
The effect of substrate aglycon on enzyme mechanism of sialidase from influenza virus was investigated by kinetic isotope effects using the substrates 4-methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid (Neu5Ac alpha 2MU) and p-nitrophenyl-N-acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775d837732cfc07e11f8a5edf1c84101
https://doi.org/10.1016/0014-5793(95)00967-e
https://doi.org/10.1016/0014-5793(95)00967-e
Autor:
R. J. Marks, Michael S Pegg
Publikováno v:
BMJ. 346:f2140-f2140
John Joseph Smirke Herbert Ruston was educated at Tonbridge School in Kent and trained at the Royal Free Hospital Medical School. During his first house job in Hastings he developed an interest in anaesthesia and met his wife, Mandy. He moved to Lond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03e8baaa89adb9b1517e255a3511128e
https://doi.org/10.1136/bmj.f2140
https://doi.org/10.1136/bmj.f2140
Autor:
Mark L. Smythe, Michael S. Pegg, Jeffrey Clifford Dyason, Gaik B. Kok, Joseph N. Varghese, Janet M. Cameron, D. Michael Ryan, Charles R. Penn, Jacqueline M. Woods, Stuart W. Oliver, Richard C. Bethell, Vanessa J. Hotham, Hume Forrest White, Tho Van Phan, Wen-Yang Wu, Mark von Itzstein, Peter M. Colman, Betty Jin
Publikováno v:
Nature. 363(6428)
Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648223fe80ceae60a82214c6fd0aa3b9
https://pubmed.ncbi.nlm.nih.gov/8502294
https://pubmed.ncbi.nlm.nih.gov/8502294
Autor:
Wendy P. Stewart, Michael S. Pegg, Mark von Itzstein, Wen-Yang Wu, Cindy T. Holzer, Betty Jin
Publikováno v:
Glycoconjugate journal. 10(1)
The inhibition of sialidase activity from influenza viruses A and B, parainfluenza 2 virus, Vibrio cholerae, Arthrobacter ureafaciens, Clostridium perfringens, and sheep liver by a range of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8f27bc8ea68973c4638607f9076c12
https://pubmed.ncbi.nlm.nih.gov/8358225
https://pubmed.ncbi.nlm.nih.gov/8358225
Publikováno v:
Trends in QSAR and Molecular Modelling 92 ISBN: 9789072199133
Trends in QSAR and Molecular Modelling 92
Trends in QSAR and Molecular Modelling 92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bdd0833b542316b5084d6ad974a22d5
https://doi.org/10.1007/978-94-011-1472-1_125
https://doi.org/10.1007/978-94-011-1472-1_125
Autor:
Michael S Pegg
Publikováno v:
BMJ. 311:877-877
EDITOR,--A recent ethical debate centres on two patients who had refused treatment in an accident and emergency department.1 One patient was admitted unconscious after an overdose of codydramol and was awakened by a dose of naloxone but then refused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6192911d2e1fac1d16fcae43aa423cf6
https://doi.org/10.1136/bmj.311.7009.877
https://doi.org/10.1136/bmj.311.7009.877