Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael S Patrick"'
Autor:
Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Akiko Takashima, Hiroyo Oda, Norimasa Tamehiro, Motohito Goto, Tadashi Okamura, Michael S Patrick, Harumi Suzuki
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89115 (2014)
Themis (also named Gasp) is a newly identified Grb2-binding protein that is essential for thymocyte positive selection. Despite the possible involvement of Themis in TCR-mediated signal transduction, its function remains unresolved and controversial.
Externí odkaz:
https://doaj.org/article/a590fe85d3e448a0ad9f583b8528cf4e
Publikováno v:
Immunology Letters. 151:1-9
RhoH is a new member of the atypical G proteins exclusively expressed in hematopoietic lineage cells. It has been shown to act as an adaptor for ZAP70, Syk, Lck and Csk kinases in signal transduction, and is required for positive selection of thymocy
Publikováno v:
The Journal of Immunology. 200:171.10-171.10
To understand the role of telomerase in T cell differentiation and function, we analyzed human telomerase reverse transcriptase (hTERT) mRNA expression and telomerase activity in six T cell subsets from 85 healthy human donors (aged 17–82 years old
Autor:
Takaya Abe, Koji Eshima, Yoshinori Sato, Mutsunori Shirai, Shun-ichiro Iemura, Hiroyo Oda, Tohru Natsume, Michael S. Patrick, Harumi Suzuki, Kunihiro Hayakawa, Takehiko Sasazuki, Teruo Kirikae
Publikováno v:
Proceedings of the National Academy of Sciences. 106:16345-16350
T cells develop in the thymus through positive and negative selection, which are responsible for shaping the T cell receptor (TCR) repertoire. To elucidate the molecular mechanisms involved in selection remains an area of intense interest. Here, we i
Autor:
Emily Pentzer, Sanjoy Paul, Nathan J. Dawson, Kenneth D. Singer, Kyle C. Peters, Robert J. Twieg, Rachael Matthews, Brett Ellman, Michael S. Patrick
Publikováno v:
SPIE Proceedings.
We report on time-of-flight (TOF) hole mobility measurements in an aged discotic columnar liquid crystal, Hexakis(pentyloxy)triphenylene (HAT5). The experimental data was fit to an interfacial trapping model based on Van de Walle’s approximations.
Quantification of hTERT alternatively spliced isoforms in resting and activated human T cell subsets
Publikováno v:
The Journal of Immunology. 198:74.6-74.6
The activity of telomerase is regulated at multiple levels of the reverse transcriptase (hTERT) subunit. In T cells, it is well documented that telomerase activity is not detected in resting cells while it is high in activated cells. However, it is u
Autor:
Harumi Suzuki, Norimasa Tamehiro, Hiroyo Oda, Takeshi Nitta, Toshiyuki Okada, Kentaro Kaji, Motohito Goto, Michael S. Patrick, Akiko Takashima, Tadashi Okamura
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89115 (2014)
PLoS ONE
PLoS ONE
Themis (also named Gasp) is a newly identified Grb2-binding protein that is essential for thymocyte positive selection. Despite the possible involvement of Themis in TCR-mediated signal transduction, its function remains unresolved and controversial.
Autor:
Michael S. Patrick, Tim R.V. Davis
Publikováno v:
Planning Review. 21:28-31
Benchmarking is being incorporated into the strategic planning and quality improvement processess of many service businesses. A case in point is the benchmarking effort by the member hospitals of the SunHealth alliance, a network of 250 non‐profit
Autor:
Robert J. Twieg, Brett Ellman, Emily Pentzer, Alexander N. Semyonov, Rachael Matthews, Sanjoy Paul, Kenneth D. Singer, Michael S. Patrick, Nathan J. Dawson
Publikováno v:
Journal of Applied Physics. 118:085502
This study reports on time-of-flight (TOF) hole mobility measurements in aged 2,3,6,7,10,11-Hexakis(pentyloxy)triphenylene columnar liquid crystals. In contrast to the original samples reported in 2006, homeotropically aligned samples yielded TOF tra
Autor:
Kazuro Sugi, Harumi Suzuki, Michael S. Patrick, Toshio Kitamura, Yoshinao Azuma, Seiji Kitahara, Kouhei Sakai, Jonathan Kaye, Hiroyo Oda, Mutsunori Shirai
Publikováno v:
Journal of leukocyte biology. 81(2)
Rac1, one of the Rho family small guanosinetriphosphatases, has been shown to work as a "molecular switch" in various signal transduc- tion pathways. To assess the function of Rac1 in the differentiation process of CD4 single-positive (CD4-SP) T cell