Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Michael S Kilberg"'
Autor:
Christopher J Fields, Lu Li, Nicholas M Hiers, Tianqi Li, Peike Sheng, Taha Huda, Jixiu Shan, Lauren Gay, Tongjun Gu, Jiang Bian, Michael S Kilberg, Rolf Renne, Mingyi Xie
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009934 (2021)
MicroRNAs (miRNA) are short non-coding RNAs widely implicated in gene regulation. Most metazoan miRNAs utilize the RNase III enzymes Drosha and Dicer for biogenesis. One notable exception is the RNA polymerase II transcription start sites (TSS) miRNA
Externí odkaz:
https://doaj.org/article/9e16ab6be9ab4e51a070766391d0856e
Autor:
Stephen J. Staklinski, Mario C. Chang, Rebecca C. Ahrens‐Nicklas, Shagun Kaur, Arianna K. Stefanatos, Elizabeth E. Dudenhausen, Matthew E. Merritt, Michael S. Kilberg
Publikováno v:
JIMD Reports, Vol 64, Iss 2, Pp 167-179 (2023)
Abstract Asparagine synthetase (ASNS) catalyzes the synthesis of asparagine (Asn) from aspartate and glutamine. Biallelic mutations in the ASNS gene result in ASNS Deficiency (ASNSD). Children with ASNSD exhibit congenital microcephaly, epileptic‐l
Externí odkaz:
https://doaj.org/article/43ff810be89c4f6e9718627d28111f9a
Autor:
Amitava Mukherjee, Nayyar Ahmed, Fateema T. Rose, Abraheem N. Ahmad, Tanveer A. Javed, Li Wen, Rita Bottino, Xiangwei Xiao, Michael S. Kilberg, Sohail Z. Husain
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 1-13 (2020)
Asparaginase (ASNase) causes pancreatitis in approximately 10% of leukemia patients, and the mechanisms underlying this painful complication are not known. ASNase primarily depletes circulating asparagine, and the endogenously expressed enzyme, aspar
Externí odkaz:
https://doaj.org/article/c25fd818c0474bc38c46bc8759cfc477
Autor:
Martina Chiu, Giuseppe Taurino, Massimiliano G. Bianchi, Michael S. Kilberg, Ovidio Bussolati
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly regulated at the transcriptional level, being induced by both the Amino Acid Res
Externí odkaz:
https://doaj.org/article/3fca4c59eabc49d8b25e55923f1a8ed3
Autor:
Mario C. Chang, Stephen J. Staklinski, Vinay R. Malut, Geraldine L. Pierre, Michael S. Kilberg, Matthew E. Merritt
Publikováno v:
Nutrients; Volume 15; Issue 8; Pages: 1938
The natural amino acid asparagine (Asn) is required by cells to sustain function and proliferation. Healthy cells can synthesize Asn through asparagine synthetase (ASNS) activity, whereas specific cancer and genetically diseased cells are forced to o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79966faedcf2ceac441d1960e958d5f
https://doi.org/10.3390/nu15081938
https://doi.org/10.3390/nu15081938
Autor:
Stephen J. Staklinski, Mario C. Chang, Fang Yu, Kathleen Collins Ruff, David N. Franz, Zhijian Qian, Linda B. Bloom, Matthew E. Merritt, Robert McKenna, Michael S. Kilberg
Publikováno v:
The Journal of biological chemistry. 298(9)
Asparagine synthetase (ASNS) catalyzes synthesis of asparagine (Asn) and Glu from Asp and Gln in an ATP-dependent reaction. Asparagine synthetase deficiency (ASNSD) results from biallelic mutations in the ASNS gene. Affected children exhibit congenit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b180d796527a9b3e0305269f1dc9b11
https://pubmed.ncbi.nlm.nih.gov/35985424
https://pubmed.ncbi.nlm.nih.gov/35985424
Autor:
Christopher J. Fields, Lu Li, Nicholas M. Hiers, Tianqi Li, Peike Sheng, Taha Huda, Jixiu Shan, Lauren Gay, Tongjun Gu, Jiang Bian, Michael S. Kilberg, Rolf Renne, Mingyi Xie
MicroRNAs (miRNA) are short non-coding RNAs widely implicated in gene regulation. Most metazoan miRNAs utilize the RNase III enzymes Drosha and Dicer for biogenesis. One notable exception is the RNA polymerase II transcription start sites (TSS) miRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c48f44e202dd972e8e7722639cca64
https://doi.org/10.1101/2021.10.05.463240
https://doi.org/10.1101/2021.10.05.463240
Autor:
Giancarlo Pruneri, Giuseppe Taurino, Luca Agnelli, Massimiliano G. Bianchi, Benedetta Dalla Palma, Valentina Franceschi, Giovanna D'Amico, Gaetano Donofrio, Jessica Burroughs-Garcia, Federica Costa, Roberta Andreoli, Ovidio Bussolati, Eugenia Martella, Nicoletta Campanini, Cristina Mancini, Rosa Alba Eufemiese, Erica Dander, Martina Chiu, Michael S. Kilberg, Denise Toscani, Valentina Marchica, Paola Storti, Nicola Giuliani, Jixiu Shan
Publikováno v:
Cancers, Vol 12, Iss 3267, p 3267 (2020)
Cancers
Volume 12
Issue 11
Cancers
Volume 12
Issue 11
Simple Summary Osteolytic bone lesions represent an important clinical feature of multiple myeloma (MM). MM cells metabolize very high amounts of glutamine (Gln) and significantly lower Gln in the bone marrow. In this contribution we demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa20f80d752d146918bf0cb960be92da
https://www.mdpi.com/2072-6694/12/11/3267
https://www.mdpi.com/2072-6694/12/11/3267
Publikováno v:
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 20(6)
The pancreas avidly takes up and synthesizes the amino acid asparagine (Asn), in part, to maintain an active translational machinery that requires incorporation of the amino acid. The de novo synthesis of Asn in the pancreas occurs through the enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae116e95191120e4cbac1be967d8558
https://pubmed.ncbi.nlm.nih.gov/32800652
https://pubmed.ncbi.nlm.nih.gov/32800652
Autor:
Zhaofeng Gao, Dawid Krokowski, Christine McDonald, Tristan J de Jesus, Xing-Huang Gao, David A. Buchner, Ganes C. Sen, Raul Jobava, Evelyn Chukwurah, Greeshma Ray, Calvin U. Cotton, Kenneth T. Farabaugh, Parameswaran Ramakrishnan, Bo-Jhih Guan, Michael S. Kilberg, Maria Hatzoglou, Jing Wu, Ovidio Bussolati, Massimiliano G. Bianchi, Michelle Suzanne Longworth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153bdcc7d1b708b5151f9c1e7ff6a5e1
https://doi.org/10.7554/elife.52241.sa2
https://doi.org/10.7554/elife.52241.sa2