Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael S Huh"'
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000594 (2020)
Alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler (ATRX), a DAXX (death domain-associated protein) interacting protein, is often lost in cells using the alternative lengthening of telomeres (ALT) pathway, but it is not known
Externí odkaz:
https://doaj.org/article/6305feaaad94470f9d5501a0e2e77e4b
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186989 (2017)
Reduced muscle mass due to pathological development can occur through several mechanisms, including the loss or reduced proliferation of muscle stem cells. Muscle-specific ablation of the α-thalassemia mental retardation syndrome mutant protein, Atr
Externí odkaz:
https://doaj.org/article/2d60244ad36f4c36a93cd93610000456
Autor:
Laura Evgin, Carolina S Ilkow, Marie-Claude Bourgeois-Daigneault, Christiano Tanese de Souza, Lawton Stubbert, Michael S Huh, Victoria A Jennings, Monique Marguerie, Sergio A Acuna, Brian A Keller, Charles Lefebvre, Theresa Falls, Fabrice Le Boeuf, Rebecca A Auer, John D Lambris, J Andrea McCart, David F Stojdl, John C Bell
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
The systemic delivery of therapeutic viruses, such as oncolytic viruses or vaccines, is limited by the generation of neutralizing antibodies. While pseudotyping of rhabdoviruses with the lymphocytic choriomeningitis virus glycoprotein has previously
Externí odkaz:
https://doaj.org/article/03318fbb20d24026bc983751bf71f24d
Autor:
Jack T. Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A. Tamming, Giuseppe Pugliese, Nikolas T. Martin, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E. F. Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S. Huh, Matt Y. Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D. Lichty, Carolina S. Ilkow, John C. Bell
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they can be readily engineered to express multiple large transgenes. However
Externí odkaz:
https://doaj.org/article/f7cfd3f77d384dec8678da5baade9481
Publikováno v:
European Journal of Human Genetics
Ribosomal RNA synthesis occurs in the nucleolus and is a tightly regulated process that is targeted in some developmental diseases and hyperactivated in multiple cancers. Subcellular localization and immunoprecipitation coupled mass spectrometry demo
Autor:
Michael S. Huh, Mathieu J.F. Crupi, Adrian Pelin, Carolina S. Ilkow, Donald Bastin, Amelia Sadie Aitken, Marie-Claude Bourgeois-Daigneault, Larissa Pikor, John C. Bell
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)
Antiviral responses are barriers that must be overcome for efficacy of oncolytic virotherapy. In mammalian cells, antiviral responses involve the interferon pathway, a protein-signaling cascade that alerts the immune system and limits virus propagati
Autor:
Manijeh Daneshmand, Sophie Cousineau, Kathryn Ottolino-Perry, David P. Conrad, Fernando A. Angarita, Caroline J. Breitbach, Christina L. Addison, Carolina S. Ilkow, Fabrice Le Boeuf, Emma Burgess, Subash Sad, John C. Bell, Marie-Claude Bourgeois-Daigneault, Jean-Simon Diallo, Michael S. Huh, Harold L. Atkins, J. Andrea McCart, Jovian Tsang, Amelia Mottashed, Theresa Falls, Cory Batenchuk, David H. Kirn, Brian D. Lichty, Rozanne Arulanandam, Grant A. Howe, Naomi De Silva, Leda Raptis
Publikováno v:
Cancer Cell. 28:210-224
SummaryOncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a consequence of VE
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186989 (2017)
PLoS ONE
PLoS ONE
Reduced muscle mass due to pathological development can occur through several mechanisms, including the loss or reduced proliferation of muscle stem cells. Muscle-specific ablation of the α-thalassemia mental retardation syndrome mutant protein, Atr
Autor:
Adrian Pelin, Matthew Y. Tang, Michael S. Huh, Bernstein Steven H, Victoria A. Jennings, Jessie Duong, Mathieu J.F. Crupi, Caroline J. Breitbach, Fabrice Le Boeuf, Katherine Clark-Knowles, Burgess Michael F, John C. Bell, Alan Melcher, Julia Petryk, Brian A. Keller, Larissa Pikor
Publikováno v:
Cancer Immunology Research. 7:B101-B101
The treatment paradigm for patients with metastatic cancer has evolved rapidly with the approval of agents targeting CTLA-4 and the PD-1/L1 immune checkpoint axis. Despite the profound impact these agents have had, they are minimally effective in the
Autor:
Bruce C. McKay, D. Ouazia, Robin J. Parks, Michael A. Rudnicki, David J. Picketts, Tina Price O’Dea, Gianni Parise, Michael S. Huh
Publikováno v:
Journal of Clinical Investigation. 122:4412-4423
ATR-X syndrome is a severe intellectual disability disorder caused by mutations in the ATRX gene. Many ancillary clinical features are attributed to CNS deficiencies, yet most patients have muscle hypotonia, delayed ambulation, or kyphosis, pointing