Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Michael S Boosalis"'
Autor:
Michael S Boosalis, Jose I Sangerman, Gary L White, Roman F Wolf, Ling Shen, Yan Dai, Emily White, Levi H Makala, Biaoru Li, Betty S Pace, Mehdi Nouraie, Douglas V Faller, Susan P Perrine
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144660 (2015)
High-level fetal (γ) globin expression ameliorates clinical severity of the beta (β) hemoglobinopathies, and safe, orally-bioavailable γ-globin inducing agents would benefit many patients. We adapted a LCR-γ-globin promoter-GFP reporter assay to
Externí odkaz:
https://doaj.org/article/2e893cb55f4d4593925e8200028f48ee
Autor:
Peter E. Newburger, P. Artur Plett, Stanley D. Kosanke, Christie M. Orschell, Michael S. Boosalis, Serguei A. Castaneda, Douglas V. Faller, Merriline Vedamony, Susan P. Perrine, Gary L. White, Daohong Zhou
An oral therapeutic which reduces duration of cytopenias and is active following accidental radiation exposures is an unmet need in radiation countermeasures. Alpha methylhydrocinnamate (ST7) prolongs STAT-5 phosphorylation, reduces growth-factor dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b617a0b25be9d88f028e96fba8a2d79
https://europepmc.org/articles/PMC5458738/
https://europepmc.org/articles/PMC5458738/
Publikováno v:
BioResearch Open Access
BioResearch Open Access, Vol 1, Iss 4, Pp 192-198 (2012)
BioResearch Open Access, Vol 1, Iss 4, Pp 192-198 (2012)
In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting DNA synthesis and cell g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4840008e3401d8d8911cef24ec7b14b0
http://europepmc.org/articles/PMC3559235
http://europepmc.org/articles/PMC3559235
Autor:
Roman F. Wolf, Douglas V. Faller, Levi Makala, Jose Sangerman, Emily White, Betty S. Pace, Gary L. White, Mehdi Nouraie, Ling Shen, Michael S. Boosalis, Biaoru Li, Susan P. Perrine, Yan Dai
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144660 (2015)
PLoS ONE, Vol 10, Iss 12, p e0144660 (2015)
High-level fetal (γ) globin expression ameliorates clinical severity of the beta (β) hemoglobinopathies, and safe, orally-bioavailable γ-globin inducing agents would benefit many patients. We adapted a LCR-γ-globin promoter-GFP reporter assay to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba3e81a05d7750e58a29b47a9a17395
http://europepmc.org/articles/PMC4694699
http://europepmc.org/articles/PMC4694699
Autor:
Allison Thies, David W. Emery, Serguei A. Castaneda, Douglas V. Faller, Susan P. Perrine, Michael S. Boosalis
Publikováno v:
Blood Cells, Molecules, and Diseases. 35:217-226
Accelerated apoptosis of erythroid progenitors is a characteristic of beta-thalassemia which presents a significant barrier to definitive therapeutic approaches utilizing induction of endogenous fetal globin gene expression. gamma-globin gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fa88459548f6c99cc90bf4df3bf3e6
https://doi.org/10.1016/j.bcmd.2005.06.007
https://doi.org/10.1016/j.bcmd.2005.06.007
Publikováno v:
Leukemia Research. 28:1125-1136
Six patients with bcr-abl positive AML or chronic myelogenous leukemia in blast crisis (CML-BC) were treated with the IMP-dehydrogenase (IMPDH) inhibitor, Tiazofurin , in a Phase-II trial. Tiazofurin was given by IV infusion (2200–2700mg/m 2 per da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12c5d7185bb684348b0b5acf8fb7077d
https://doi.org/10.1016/j.leukres.2004.03.003
https://doi.org/10.1016/j.leukres.2004.03.003
Autor:
Alexei Stortchevoi, Ellinor I.B. Peerschke, Daniel B. Rubinstein, Thierry Guillaume, Raheela Ashfaq, Michael S. Boosalis, Fabien Calvo, Berhane Ghebrehiwet
Publikováno v:
International Journal of Cancer. 110:741-750
Combinatorial Ig libraries with phage display allow in vitro generation of human Ig fragments without the need to maintain hybridomas in ongoing cell culture or to select circulating Ig from human serum. Identifying tumor-associated antigens on the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de136726addecb0a2db7f4a9f3a713e1
https://doi.org/10.1002/ijc.20105
https://doi.org/10.1002/ijc.20105
Autor:
Susan P. Perrine, Douglas V. Faller, Ram S. Bandyopadhyay, Betty S. Pace, Baohua Zhang, Michael S. Boosalis, Karyn Van DeMark, Emery H. Bresnick
Publikováno v:
Blood. 97:3259-3267
Current chemotherapeutic and butyrate therapeutics that induce fetal hemoglobin expression generally also suppress erythropoiesis, limiting the production of cells containing fetal hemoglobin (F cells). Recently, selected short-chain fatty acid deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d0d602c1c07bd35b367591c1c020e3
https://doi.org/10.1182/blood.v97.10.3259
https://doi.org/10.1182/blood.v97.10.3259
Autor:
Gary L. White, George F. Atweh, Michael S. Boosalis, Silvana D.A. Fonseca, Douglas V. Faller, Vassiliki Boosalis, Tohru Ikuta, Susan P. Perrine
Publikováno v:
Annals of the New York Academy of Sciences. 850:87-99
Cooley's anemia is characterized by a deficiency of beta-globin chains, a relative excess of alpha-globin chains, and consequent accelerated programmed death of developing erythroid cells in the bone marrow. Increasing expression of the gamma-globin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dce44d63a3af8de2710a60196a5bf3
https://doi.org/10.1111/j.1749-6632.1998.tb10466.x
https://doi.org/10.1111/j.1749-6632.1998.tb10466.x
Autor:
Silvana D.A. Fonseca, Betty S. Pace, Gary L. White, Douglas V. Faller, Tohru Ikuta, Susan P. Perrine, Michael S. Boosalis
Publikováno v:
Blood Cells, Molecules, and Diseases. 23:434-442
Short-chain fatty acids, such as butyrate and propionate, induce fetal globin gene expression and are under clinical investigation in the beta-hemoglobinopathies. Limitations of the short-chain fatty acids as therapeutics include their rapid metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e0db72c4d23a770e6b2ac56b7aff95
https://doi.org/10.1006/bcmd.1997.0162
https://doi.org/10.1006/bcmd.1997.0162