Výsledky vyhledávání - "Michael S, Nelson"

Akademický článek

Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

Autor: Young-Woong Kim, Greta Zara, HyunJun Kang, Sergio Branciamore, Denis O’Meally, Yuxin Feng, Chia-Yi Kuan, Yingjun Luo, Michael S. Nelson, Alex B. Brummer, Russell Rockne, Zhen Bouman Chen, Yi Zheng, Angelo A. Cardoso, Nadia Carlesso

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Here Kim et al. show that primary BMECs can be maintained ex vivo as distinct sinusoidal- and arterial-like populations and that the presence of macrophages is critical to preserve their native transcriptomic profiles and functional heterogeneity.

Externí odkaz: https://doaj.org/article/9ee80c4c324443f1b1bf968f84b4c61f

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Akademický článek

Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

Autor: Wilma Tixi, Maricela Maldonado, Ya-Ting Chang, Amy Chiu, Wilson Yeung, Nazia Parveen, Michael S Nelson, Ryan Hart, Shihao Wang, Wu Jih Hsu, Patrick Fueger, Janel L Kopp, Mark O Huising, Sangeeta Dhawan, Hung Ping Shih

Publikováno v: eLife, Vol 12 (2023)

Pancreatic islets are three-dimensional cell aggregates consisting of unique cellular composition, cell-to-cell contacts, and interactions with blood vessels. Cell aggregation is essential for islet endocrine function; however, it remains unclear how

Externí odkaz: https://doaj.org/article/1af8a5ad4f5e48b9ad89b0e0e5e6d997

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Akademický článek

A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

Autor: Daniela Castanotto, Xiaowei Zhang, Jacqueline Rüger, Jessica Alluin, Ritin Sharma, Patrick Pirrotte, Lars Joenson, Silvia Ioannou, Michael S. Nelson, Jonas Vikeså, Bo Rode Hansen, Troels Koch, Mads Aaboe Jensen, John J. Rossi, Cy A. Stein

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 63-75 (2021)

The androgen receptor (AR) plays a critical role in the development of prostate cancer (PCa) through the activation of androgen-induced cellular proliferation genes. Thus, blocking AR-mediated transcriptional activation is expected to inhibit the gro

Externí odkaz: https://doaj.org/article/05d438d8c2914f6a92b4a9a5650737aa

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Akademický článek

Tumor-infiltrating exhausted CD8+ T cells dictate reduced survival in premenopausal estrogen receptor–positive breast cancer

Autor: Colt A. Egelston, Weihua Guo, Jiayi Tan, Christian Avalos, Diana L. Simons, Min Hui Lim, Yinghui J. Huang, Michael S. Nelson, Arnab Chowdhury, Daniel B. Schmolze, John H. Yim, Laura Kruper, Laleh Melstrom, Kim Margolin, Joanne E. Mortimer, Yuan Yuan, James R. Waisman, Peter P. Lee

Publikováno v: JCI Insight, Vol 7, Iss 3 (2022)

CD8+ tumor-infiltrating lymphocytes (TILs) are associated with improved survival in triple-negative breast cancer (TNBC) yet have no association with survival in estrogen receptor–positive (ER+) BC. The basis for these contrasting findings remains

Externí odkaz: https://doaj.org/article/71630b8f86fc4c07b75223a29542c6d2

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Akademický článek

Differentiation of pancreatic ductal adenocarcinoma and chronic pancreatitis using graph neural networks on histopathology and collagen fiber features

Autor: Bin Li, Michael S. Nelson, Omid Savari, Agnes G. Loeffler, Kevin W. Eliceiri

Publikováno v: Journal of Pathology Informatics, Vol 13, Iss , Pp 100158- (2022)

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. However, the symptoms and radiographic appearance of chronic pancreatitis (CP) mimics that of PDAC, and sometimes the 2 entities can also be difficult to differentiate m

Externí odkaz: https://doaj.org/article/556fa16e8f2741ed9c5f6038973a1bdb

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Akademický článek

Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas

Autor: Saumya Srivastava, Ka Ming Pang, Mari Iida, Michael S. Nelson, Jiayi Liu, Arin Nam, Jiale Wang, Isa Mambetsariev, Raju Pillai, Atish Mohanty, Nellie McDaniel, Amita Behal, Prakash Kulkarni, Deric L. Wheeler, Ravi Salgia

Publikováno v: iScience, Vol 23, Iss 11, Pp 101692- (2020)

Summary: The tyrosine kinase receptor ephrin receptor A2 (EPHA2) is overexpressed in lung (LSCC) and head and neck (HNSCC) squamous cell carcinomas. Although EPHA2 can inhibit tumorigenesis in a ligand-dependent fashion via phosphorylation of Y588 an

Externí odkaz: https://doaj.org/article/862bc629bc1841d3ab9053896facbb15

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