Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael S, Lopez"'
Autor:
Alexander A Warkentin, Michael S Lopez, Elisabeth A Lasater, Kimberly Lin, Bai-Liang He, Anskar YH Leung, Catherine C Smith, Neil P Shah, Kevan M Shokat
Publikováno v:
eLife, Vol 3 (2014)
Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and mye
Externí odkaz:
https://doaj.org/article/2fc4b7634483440a90814b4285cadf5e
Autor:
Amarendar Reddy Maddirala, Jennifer Barks, Kevan M. Shokat, Nathaniel G. Jones, James W. Janetka, Majida El Bakkouri, Shaojun Long, Michael S. Lopez, Raymond Hui, L. David Sibley, Mary Savari Dhason, Qiuling Wang, Joshua B. Radke, Florentine U. Rutaganira
Publikováno v:
Journal of Medicinal Chemistry. 60:9976-9989
Calcium dependent protein kinase 1 (CDPK1) is an essential enzyme in the opportunistic pathogen Toxoplasma gondii. CDPK1 controls multiple processes that are critical to the intracellular replicative cycle of T. gondii including secretion of adhesins
Autor:
Zora Modrusan, Min Xu, Eric J. Brown, Mark McCreary, Donghong Yan, Cary D. Austin, Irene S. Tan, Jing Kang, Michael S. Lopez
Publikováno v:
Proceedings of the National Academy of Sciences. 114:11223-11228
The type VII secretion system (T7SS) of Staphylococcus aureus is a multiprotein complex dedicated to the export of several virulence factors during host infection. This virulence pathway plays a key role in promoting bacterial survival and the long-t
Autor:
Christopher M. Koth, Michael S. Lopez, Christine C. Jao, Mary Kate Alexander, Nicholas N. Nickerson, Steven T. Rutherford, John G. Quinn, Nicholas J. Skelton, Yiming Xu, Elizabeth Skippington, Jessica V. Hankins, Mireille Nishiyama, Anh Miu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
The outer membrane is an essential structural component of Gram-negative bacteria that is composed of lipoproteins, lipopolysaccharides, phospholipids, and integral β-barrel membrane proteins. A dedicated machinery, called the Lol system, ensures pr
Autor:
Michael S, Lopez, Irene S, Tan, Donghong, Yan, Jing, Kang, Mark, McCreary, Zora, Modrusan, Cary D, Austin, Min, Xu, Eric J, Brown
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(42)
Staphylococcus aureus is one of the most adaptable and prolific human pathogens, and it employs an arsenal of virulence factors to infect blood, bone, and soft tissues. The type VII secretion system (T7SS) is a dedicated virulence protein-secretion p
Autor:
Jonathan W. Choy, Ulf Peters, Michael S. Lopez, Martin L. Sos, David O. Morgan, Kevan M. Shokat
Publikováno v:
Journal of the American Chemical Society. 135:18153-18159
Analog-sensitive (AS) kinase technology is a powerful approach for studying phospho-signaling pathways in diverse organisms and physiological processes. The key feature of this technique is that a kinase-of-interest can be mutated to sensitize it to
Publikováno v:
Chemistry & Biology. 15:1015-1022
SummaryThe cancer drug, Imatinib, is a selective Abl kinase inhibitor that does not inhibit the closely related kinase c-Src. This one drug and its ability to selectively inhibit Abl over c-Src has been a guiding principle in virtually all kinase dru
Autor:
Anskar Y.H. Leung, Kevan M. Shokat, Neil P. Shah, Alexander A. Warkentin, Elisabeth A. Lasater, Catherine C. Smith, Bai-Liang He, Michael S. Lopez, Kimberly C. Lin
Publikováno v:
eLife, Vol 3 (2014)
eLife
eLife
Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and mye
Autor:
Bai-Liang He, Michael S. Lopez, Anskar Y.H. Leung, Catherine C. Smith, Kevan M. Shokat, Kimberly C. Lin, Alexander A. Warkentin, Neil P. Shah, Elisabeth A. Lasater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::789662e630e624f7f365c25ef5894f56
https://doi.org/10.7554/elife.03445.010
https://doi.org/10.7554/elife.03445.010
Publikováno v:
Methods in enzymology. 548
Analog-sensitive AS Kinase technology allows for rapid, reversible, and highly specific inhibition of individual engineered kinases in cells and in mouse models of human diseases. The technique consists of two parts: a kinase containing a space-creat