Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Michael S, Levine"'
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109355- (2024)
Summary: The evolution of gene expression programs underlying the development of vertebrates remains poorly characterized. Here, we present a comprehensive proteome atlas of the model chordate Ciona, covering eight developmental stages and ∼7,000 t
Externí odkaz:
https://doaj.org/article/c45e524c6efa479e821c389cc230dc42
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Huntington’s disease (HD) is a fatal, hereditary neurodegenerative disorder that causes chorea, cognitive deficits, and psychiatric symptoms. It is characterized by accumulation of mutant Htt protein, which primarily impacts striatal medium-sized s
Externí odkaz:
https://doaj.org/article/2dfd76722f8b4440a7661a50f68ad006
Autor:
Joshua Barry, Katerina D. Oikonomou, Allison Peng, Daniel Yu, Chenyi Yang, Peyman Golshani, Christopher J. Evans, Michael S. Levine, Carlos Cepeda
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
Opioids are the most common medications for moderate to severe pain. Unfortunately, they also have addictive properties that have precipitated opioid misuse and the opioid epidemic. In the present study, we examined the effects of acute administratio
Externí odkaz:
https://doaj.org/article/f3c1a56a3b2a46759a146183625a03d0
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105574- (2022)
Huntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and psychiatric symptoms. Histopathologically, there is a massive loss of stri
Externí odkaz:
https://doaj.org/article/15c95e1409ae43cdaff29b2eb915034a
Autor:
Justin L. Shobe, Elissa J. Donzis, Kwang Lee, Samiksha Chopra, Sotiris C. Masmanidis, Carlos Cepeda, Michael S. Levine
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105447- (2021)
Huntington's disease (HD) is a progressive, fatal neurodegenerative disorder characterized by motor, cognitive, and psychiatric disturbances. There is no known cure for HD, but its progressive nature allows for early therapeutic intervention. Current
Externí odkaz:
https://doaj.org/article/23018235b2024f95bbe738d7aa2c872f
Autor:
Ana C Sias, Ashleigh K Morse, Sherry Wang, Venuz Y Greenfield, Caitlin M Goodpaster, Tyler M Wrenn, Andrew M Wikenheiser, Sandra M Holley, Carlos Cepeda, Michael S Levine, Kate M Wassum
Publikováno v:
eLife, Vol 10 (2021)
Adaptive reward-related decision making often requires accurate and detailed representation of potential available rewards. Environmental reward-predictive stimuli can facilitate these representations, allowing one to infer which specific rewards mig
Externí odkaz:
https://doaj.org/article/f13e8ca44fc446ad953247be2041e83e
Autor:
Simon Levinson, Conny H. Tran, Joshua Barry, Brett Viker, Michael S. Levine, Harry V. Vinters, Gary W. Mathern, Carlos Cepeda
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
In the present study, we characterized the effects of bath application of the proconvulsant drug 4-aminopyridine (4-AP) alone or in combination with GABAA and/or GABAB receptor antagonists, in cortical dysplasia (CD type I and CD type IIa/b), tuberou
Externí odkaz:
https://doaj.org/article/4b1997950ca44d958256466b41bed4c3
Autor:
Jack C. Reidling, Aroa Relaño-Ginés, Sandra M. Holley, Joseph Ochaba, Cindy Moore, Brian Fury, Alice Lau, Andrew H. Tran, Sylvia Yeung, Delaram Salamati, Chunni Zhu, Asa Hatami, Carlos Cepeda, Joshua A. Barry, Talia Kamdjou, Alvin King, Dane Coleal-Bergum, Nicholas R. Franich, Frank M. LaFerla, Joan S. Steffan, Mathew Blurton-Jones, Charles K. Meshul, Gerhard Bauer, Michael S. Levine, Marie-Francoise Chesselet, Leslie M. Thompson
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 58-72 (2018)
Summary: Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment
Externí odkaz:
https://doaj.org/article/6a20e0b98a194e96bbd0862727f88f6d
Autor:
Anna Parievsky, Cindy Moore, Talia Kamdjou, Carlos Cepeda, Charles K. Meshul, Michael S. Levine
Publikováno v:
Neurobiology of Disease, Vol 108, Iss , Pp 29-44 (2017)
Huntington's disease (HD) is a fatal genetic disorder characterized by cell death of medium-sized spiny neurons (MSNs) in the striatum, traditionally attributed to excessive glutamate inputs and/or receptor sensitivity. While changes in corticostriat
Externí odkaz:
https://doaj.org/article/d2d42360bf334fbda93da5b4ae26f200
Autor:
Kwang Lee, Konstantin I. Bakhurin, Leslie D. Claar, Sandra M. Holley, Natalie C. Chong, Carlos Cepeda, Michael S. Levine, Sotiris C. Masmanidis
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2438-2449.e4 (2019)
Summary: The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior. The lateral striatum receives overlapping input
Externí odkaz:
https://doaj.org/article/6687792c86704d40893e8394ebcf8d59