Zobrazeno 1 - 10
of 382
pro vyhledávání: '"Michael S, Kobor"'
Autor:
Alexandre A. Lussier, Isabel K. Schuurmans, Anna Großbach, Julie Maclsaac, Kristy Dever, Nastassja Koen, Heather J. Zar, Dan J. Stein, Michael S. Kobor, Erin C. Dunn
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract DNA methylation (DNAm) is the most commonly measured epigenetic mechanism in human populations, with most studies using Illumina arrays to assess DNAm levels. In 2023, Illumina updated their DNAm arrays to the EPIC version 2 (EPICv2), buildi
Externí odkaz:
https://doaj.org/article/45bc3d1658e04f92acaf7744d5dae6f1
Autor:
Sarina Abrishamcar, Beryl C. Zhuang, Mara Thomas, Nicole Gladish, Julia L. MacIsaac, Meaghan J. Jones, Elinor Simons, Theo J. Moraes, Piush J. Mandhane, Jeffrey R. Brook, Padmaja Subbarao, Stuart E. Turvey, Edith Chen, Gregory E. Miller, Michael S. Kobor, Anke Hüls
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Maternal stress and depression during pregnancy and the first year of the infant’s life affect a large percentage of mothers. Maternal stress and depression have been associated with adverse fetal and childhood outcomes as well as differen
Externí odkaz:
https://doaj.org/article/04feef9201f24f2b91d0ff2cf9a360b7
Autor:
Ola E. Salama, Nikho Hizon, Melissa Del Vecchio, Kurt Kolsun, Mario A. Fonseca, David T. S. Lin, Oscar Urtatiz, Julia L. MacIsaac, Michael S. Kobor, Elizabeth A. C. Sellers, Vernon W. Dolinsky, Allison B. Dart, Meaghan J. Jones, Brandy A. Wicklow
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Objective Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is known to be a specific ris
Externí odkaz:
https://doaj.org/article/7bffa8c1e7684ef8bb5927a17a02682a
Autor:
Gillian England-Mason, Sarah M. Merrill, Jiaying Liu, Jonathan W. Martin, Amy M. MacDonald, David W. Kinniburgh, Nicole Gladish, Julia L. MacIsaac, Gerald F. Giesbrecht, Nicole Letourneau, Michael S. Kobor, Deborah Dewey
Publikováno v:
Epigenomes, Vol 8, Iss 3, p 31 (2024)
We examined whether prenatal exposure to two classes of endocrine-disrupting chemicals (EDCs) was associated with infant epigenetic age acceleration (EAA), a DNA methylation biomarker of aging. Participants included 224 maternal–infant pairs from a
Externí odkaz:
https://doaj.org/article/ee0d31bff686479e805e23e999284c77
Autor:
Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. MacIsaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older individuals. As epigene
Externí odkaz:
https://doaj.org/article/19ba354ebb6d410cb6decf8eb0a5ba68
Autor:
Marcia Smiti Jude, Chen Xi Yang, Fernando Studart Leitao Filho, Ana I. Hernandez Cordero, Julia Yang, Tawimas Shaipanich, Xuan Li, David Lin, Julie MacIsaac, Michael S. Kobor, Sunita Sinha, Corey Nislow, Amrit Singh, Wan Lam, Stephen Lam, Silvia Guillemi, Marianne Harris, Julio Montaner, Raymond T. Ng, Christopher Carlsten, S. F. Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD) independent of cigarette smoking. We hypothesized that dysbiosis in PLWH is associated with epigenetic and transcriptom
Externí odkaz:
https://doaj.org/article/3bbc99c6afb9461b8675959190300c9f
Autor:
Ana I. Hernandez Cordero, Xuan Li, Julia Yang, Chen Xi Yang, Tawimas Shaipanich, Julie L. MacIsaac, Kristy Dever, Michael S. Kobor, Julio Montaner, Marianne Harris, Silvia Guillemi, Shu Fan Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1261 (2024)
Background: DNA methylation may be a link between HIV, aging, and the increased risk of lung comorbidities. We investigated whether bronchoalveolar lavage (BAL) cells of people living with HIV (PLWH) demonstrate epigenetic disruptions and advanced ep
Externí odkaz:
https://doaj.org/article/f701d3d267eb4a0f96bcf938a909d574
Autor:
Junyu Chen, Evan Gatev, Todd Everson, Karen N. Conneely, Nastassja Koen, Michael P. Epstein, Michael S. Kobor, Heather J. Zar, Dan J. Stein, Anke Hüls
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Recent efforts have focused on developing methylation risk scores (MRS), a weighted sum of the individual’s DNA methylation (DNAm) values of pre-selected CpG sites. Most of the current MRS approaches that utilize Epigenome-wide association studies
Externí odkaz:
https://doaj.org/article/4babd77b39d246af9c962658b9fdc9ec
Autor:
Kurt P. Kolsun, BSc, Samantha Lee, MSc, Julia L. MacIsaac, PhD, Padmaja Subbarao, MD, MSc, Theo J. Moraes, MD, PhD, Piushkumar J. Mandhane, MD, PhD, Stuart E. Turvey, MBBS, DPhil, Michael S. Kobor, PhD, Meaghan J. Jones, PhD, Elinor Simons, MD, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 4, Pp 100130- (2023)
Background: In the first year of life, DNA methylation (DNAm) patterns are established and are particularly susceptible to exposure-induced changes. Some of these changes may leave lasting effects by persistently altering gene expression or cell type
Externí odkaz:
https://doaj.org/article/81f55578c405431387e605d6ca784ed9
Publikováno v:
Discover Social Science and Health, Vol 3, Iss 1, Pp 1-21 (2023)
Abstract Human social epigenomics research is critical to elucidate the intersection of social and genetic influences underlying racial and ethnic differences in health and development. However, this field faces major challenges in both methodology a
Externí odkaz:
https://doaj.org/article/e62738b783804266ba3f7c857e841412