Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Michael S, Dodd"'
1
Akademický článek
Haematological and biochemical pathology markers for a predictive model for ITU admission and death from COVID‐19: A retrospective study
Autor: Anuja Rasarathnam, Terrence Haynes‐Smith, Wassif S. Wassif, Michael S. Dodd
Publikováno v: eJHaem, Vol 3, Iss 3, Pp 660-668 (2022)
Abstract Coronavirus disease (COVID‐19) caused by SARS‐CoV‐2 has affected over 227 countries. Changes in haematological and biochemical characteristics in patients with COVID‐19 are emerging as important features of the disease. This study ai
Externí odkaz: https://doaj.org/article/d79924af7c2a4a41aaa5be832be0a693
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2
Akademický článek
CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets
Autor: Linford J.B. Briant, Michael S. Dodd, Margarita V. Chibalina, Nils J.G. Rorsman, Paul R.V. Johnson, Peter Carmeliet, Patrik Rorsman, Jakob G. Knudsen
Publikováno v: Cell Reports, Vol 23, Iss 11, Pp 3300-3311 (2018)
Summary: Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose sup
Externí odkaz: https://doaj.org/article/5968a2edf07a4115802dca31633e2c1c
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3
Metabolism
Autor: Ayesha Judge, Michael S. Dodd
Publikováno v: Essays in Biochemistry
Metabolism consists of a series of reactions that occur within cells of living organisms to sustain life. The process of metabolism involves many interconnected cellular pathways to ultimately provide cells with the energy required to carry out their
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77eebee6d96a31c3005a16d68f5ebd2
https://doi.org/10.1042/ebc20190041
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6
Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized
Autor: Oliver J, Rider, Andrew, Apps, Jack J J J, Miller, Justin Y C, Lau, Andrew J M, Lewis, Mark A, Peterzan, Michael S, Dodd, Angus Z, Lau, Claire, Trumper, Ferdia A, Gallagher, James T, Grist, Kevin M, Brindle, Stefan, Neubauer, Damian J, Tyler
Publikováno v: Circulation Research
Supplemental Digital Content is available in the text.
Rationale: The recent development of hyperpolarized 13C magnetic resonance spectroscopy has made it possible to measure cellular metabolism in vivo, in real time. Objective: By comparing par
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f69a758b61279418e2614b00e4791b9
https://pubmed.ncbi.nlm.nih.gov/32078413
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7
The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right
Autor: Michael S. Dodd, Matthew Kerr, Lisa C. Heather
Publikováno v: Clinical Science. 131:2079-2094
Fatty acids (FA) are the main fuel used by the healthy heart to power contraction, supplying 60–70% of the ATP required. FA generate more ATP per carbon molecule than glucose, but require more oxygen to produce the ATP, making them a more energy de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46fcd166b15df0a65784f7af8bc5059
https://doi.org/10.1042/cs20160671
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8
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes
Autor: Alan Smith, Tom Ashmore, Andrew J. Murray, Julian L. Griffin, Brianna J. Stubbs, Scott Drawer, Rhys D. Evans, Stefan Neubauer, Tom Kirk, Pete J. Cox, Kieran Clarke, Richard L. Veech, Stewart W. McLure, James A. West, Cameron J. Holloway, Kristof Willerton, M. Todd King, Michael S. Dodd
Publikováno v: Cell Metabolism. 24:256-268
Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering oxidative fuel selection. Often overlooked for its metabolic potential, ketosis is poorly understood outside of starvation or diabetic crisis. Thus, we studi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093f56af8ed2bffc32f617aee8b58123
https://doi.org/10.1016/j.cmet.2016.07.010
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9
Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
Autor: Michael S. Dodd, Jack J. Miller, Cher-Rin Chong, Damian J. Tyler, Vicky Ball, Kerstin N. Timm, Andrew Apps
Publikováno v: Nmr in Biomedicine
Timm, K N, Apps, A, Miller, J J, Ball, V, Chong, C R, Dodd, M S & Tyler, D J 2018, ' Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS ', NMR in Biomedicine, vol. 31, no. 9, e3992 . https://doi.org/10.1002/nbm.3992
Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy can measure cardiac pyruvate dehydrogenase (PDH) flux in vivo through 13C-label incorporation into bicarbonate. Using this technology substrate availability as well as pathology have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dea282ab18b9f6b301340941d657d5
http://europepmc.org/articles/PMC6175301
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10
P33 Pharmacological stimulation of HIF signalling as a potential treatment approach for the type 2 diabetic heart
Autor: Fialho Mdls., Claudia N. Montes Aparicio, Matthew Kerr, Michael S. Dodd, Damian J. Tyler, Lisa C. Heather
Publikováno v: Abstracts.
Introduction In response to ischemia, type 2 diabetic hearts are less able to upregulate anaerobic glycolysis and show poorer contractile function. Pharmacological activation of Hypoxia-Inducible Factor (HIF) may be beneficial for the diabetic heart,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba92d7e6f62eac8aca3b7a839560b116
https://doi.org/10.1136/heartjnl-2018-bscr.38
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