Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Michael Rugaard Jensen"'
Autor:
Federica Zilli, Pedro Marques Ramos, Priska Auf der Maur, Charly Jehanno, Atul Sethi, Marie‐May Coissieux, Tobias Eichlisberger, Loïc Sauteur, Adelin Rouchon, Laura Bonapace, Joana Pinto Couto, Roland Rad, Michael Rugaard Jensen, Andrea Banfi, Michael B Stadler, Mohamed Bentires‐Alj
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Metastasis is the main cause of deaths related to solid cancers. Active transcriptional programmes are known to regulate the metastatic cascade but the molecular determinants of metastatic colonization remain elusive. Using an inducible pigg
Externí odkaz:
https://doaj.org/article/42ad8c50455f42c9bfe8d2e92e8ddc15
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 69K, Supplemental Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5cc944f3707f5ad259f84b88e0f28a
https://doi.org/10.1158/1535-7163.22500510
https://doi.org/10.1158/1535-7163.22500510
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of which are important in non–small cell lung cancer (NSCLC) pathogenesis. We sought to define preclinical effects of the H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340bde653ea76e976bddef604a102046
https://doi.org/10.1158/1535-7163.c.6536484.v1
https://doi.org/10.1158/1535-7163.c.6536484.v1
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 769K, Heat maps from microarray analyses of gene expression changes seen in at least 13 of 16 experiments after exposure to NVP-AUY922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2337f1f4ea5f861ba5a922f87b2c414c
https://doi.org/10.1158/1535-7163.22500516.v1
https://doi.org/10.1158/1535-7163.22500516.v1
Autor:
Dennis J. Slamon, Steven M. Dubinett, Manway Liu, Cornelia Quadt, Michael Rugaard Jensen, Emin Avsar, Susan Ide, Wylie Hosmer, Amrita J. Desai, Naeimeh Kamranpour, Sharon Pitts, Judy Dering, Habib Hamidi, Richard S. Finn, Edward B. Garon
PDF - 47B, A tabular demonstration of the efficacy and tolerability of NVP-AUY922 in 32 mice carrying subcutaneous A549 or H1975 xenograft tumors randomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3156a31aed59157028623a7831bffe
https://doi.org/10.1158/1535-7163.22500507
https://doi.org/10.1158/1535-7163.22500507
Autor:
Michael Rugaard Jensen, Carlos Garcia-Echeverria, Mike Wood, Alain Schweitzer, Stephan Ruetz, Thomas Radimerski, Ulrike Pfaar, Martin J. Drysdale, Patrick Chène, Josef Brueggen, Paul A. Brough, Joseph Schoepfer, Andrew J. Massey
Supplementary Tables from Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP800
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a342dabe573f6fb9bc0b61813d5b8c
https://doi.org/10.1158/1535-7163.22484990.v1
https://doi.org/10.1158/1535-7163.22484990.v1
Autor:
Cheng Li, Francesco Hofmann, Kathleen Sprouffske, Ramona Rebmann, Verena Waehle, Saskia M. Brachmann, Michael Rugaard Jensen, Stephane Ferretti, Grainne Kerr, Anirudh Prahallad, Ulrike Naumann, Audrey Kauffmann, Hans Bitter
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 323-331 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Genetic heterogeneity within a tumor arises by clonal evolution, and patients with highly heterogeneous tumors are more likely to be resistant to therapy and have reduced survival. Clonal evolution also occurs when a subset of
Genetic heterogeneity within a tumor arises by clonal evolution, and patients with highly heterogeneous tumors are more likely to be resistant to therapy and have reduced survival. Clonal evolution also occurs when a subset of
Autor:
Emil T. Kuriakose, Vincent Romanet, Swann Gaulis, Philipp Holzer, Grainne Kerr, Nelson Guerreiro, Dario Sterker, Emilie A. Chapeau, Astrid Jullion, Jeanette Fuchs, Francesco Hofmann, Sébastien Jeay, Jens Würthner, Masato Murakami, Joerg Kallen, Stephan Ruetz, Audrey Kauffmann, Marta Cortes-Cros, Pascal Furet, Therese-Marie Stachyra, William R. Sellers, Markus Wartmann, Michael Rugaard Jensen, Marion Wiesmann, Eric Durand, Stephane Ferretti, Ensar Halilovic
Publikováno v:
Cancer Research. 78:6257-6267
Activation of p53 by inhibitors of the p53–MDM2 interaction is being pursued as a therapeutic strategy in p53 wild-type cancers. Here, we report distinct mechanisms by which the novel, potent, and selective inhibitor of the p53–MDM2 interaction H
Autor:
Ram Kumar Selvaraju, Azita Monazzam, Su-Chen Li, E. Briard, Michael Rugaard Jensen, Z. P. Jayendra, Sergio Estrada, Patrik Nordeman, Ola Åberg, Gunnar Antoni, Mats Larhed, Peter Stålberg, Britt Skogseid
Publikováno v:
European Journal of Pharmaceutical Sciences. 157:105647
Purpose With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), we developed and preliminary validated a novel fluorine-18 labelled HSP90 ligand. Methods A precursor containing methoxymethyl ethers protecting group
Publikováno v:
Current opinion in geneticsdevelopment. 54
Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral gene