Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael Rubart-von der Lohe"'
Autor:
Juli Liu, Yucheng Zhang, Lei Han, Shuai Guo, Shiyong Wu, Emma Helen Doud, Cheng Wang, Hanying Chen, Michael Rubart-von der Lohe, Jun Wan, Lei Yang
Publikováno v:
Stem Cell Reports. 17:522-537
Patients with coronavirus disease 2019 (COVID-19) commonly have manifestations of heart disease. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome encodes 27 proteins. Currently, SARS-CoV-2 gene-induced abnormalities of human heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a789f553ecf31b12fc6e397b17ee7e3
https://doi.org/10.1016/j.stemcr.2022.01.014
https://doi.org/10.1016/j.stemcr.2022.01.014
Autor:
Sean P. Reuter, Mark H. Soonpaa, Dorothy Field, Ed Simpson, Michael Rubart-von der Lohe, Han Kyu Lee, Arthi Sridhar, Stephanie M. Ware, Nick Green, Xiaochun Li, Susan Ofner, Douglas A. Marchuk, Kai C. Wollert, Loren J. Field
Publikováno v:
Circulation.
Background: Identifying genetic variants that affect the level of cell cycle reentry and establishing the degree of cell cycle progression in those variants could help guide development of therapeutic interventions aimed at effecting cardiac regenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59cc26eb94bae91ceb524845fdcc3af
https://pubmed.ncbi.nlm.nih.gov/36382596
https://pubmed.ncbi.nlm.nih.gov/36382596
Autor:
Adonis Z. Wu, Na Yang, Shien-Fong Lin, Mu Chen, Michael Rubart-von der Lohe, Zhipeng Tian, Changyu Shen, Nicholas J. Kamp, Peng Sheng Chen, Dongzhu Xu, Dechun Yin, Zhenhui Chen, Thomas H. Everett, Zhuo Wang
Publikováno v:
Heart Rhythm. 17:332-340
Background Ondansetron, a widely prescribed antiemetic, has been implicated in drug-induced long QT syndrome. Recent patch clamp experiments have shown that ondansetron inhibits the apamin-sensitive small conductance calcium-activated potassium curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ebb3529cbf24993a19e28bd9f1bb92
https://doi.org/10.1016/j.hrthm.2019.09.008
https://doi.org/10.1016/j.hrthm.2019.09.008
Autor:
Juli Liu, Yucheng Zhang, Shiyong Wu, Lei Han, Cheng Wang, Sheng Liu, Ed Simpson, Ying Liu, Yue Wang, Weinian Shou, Yunlong Liu, Michael Rubart-von der Lohe, Jun Wan, Lei Yang
Cardiac manifestations are commonly observed in COVID-19 patients and prominently contributed to overall mortality. Human myocardium could be infected by SARS-CoV-2, and human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are susceptible to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a103fcb865e416376ac81644159436ea
https://doi.org/10.1101/2022.01.20.477147
https://doi.org/10.1101/2022.01.20.477147
Autor:
Michael Rubart-von der Lohe, Vincent M. Christoffels, Joshua W. Vincentz, Dan E. Arking, Peng Sheng Chen, Nona Sotoodehnia, Beth A. Firulli, Corrie de Gier-de Vries, Kevin P. Toolan, Juyi Wan, Anthony B. Firulli
Publikováno v:
Circ Res
Circulation research, 125(6), 575-589. Lippincott Williams and Wilkins
Circulation research, 125(6), 575-589. Lippincott Williams and Wilkins
Rationale: The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ee5ff17896b8b9e53d812b716dd834
https://doi.org/10.1161/circresaha.119.315313
https://doi.org/10.1161/circresaha.119.315313
Autor:
Rajani M. George, Ronald M Payne, Loren J. Field, Hongyu Gao, Michael Rubart-von der Lohe, Weinian Shou, Anthony B. Firulli, Wenjun Zhang, Jade Harkin, Beth A. Firulli, Ying Liu, Kevin P. Toolan, Yunlong Liu
Publikováno v:
Cardiovasc Res
AimsTo examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium.Methods and resultsHand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4eb9e7a7d5a88d1eee42c91a0d485c
https://doi.org/10.1093/cvr/cvz182
https://doi.org/10.1093/cvr/cvz182
Autor:
Michael Rubart-von der Lohe, Shuai Guo, James N. Weiss, Peng Sheng Chen, Akira Ueoka, Zhilin Qu, Thomas H. Everett, Yu-Dong Fei, Zhenhui Chen, Mu Chen
Publikováno v:
Heart Rhythm
BACKGROUND: Concomitant apamin-sensitive small conductance, calcium activated potassium current (I(KAS)) activation and I(Na) inhibition induce J-wave syndrome (JWS) in rabbit hearts. Sudden death in JWS occurs predominantly in men at night, when par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17af47bec2b13b61935d569862aa67f6
https://pubmed.ncbi.nlm.nih.gov/32763429
https://pubmed.ncbi.nlm.nih.gov/32763429
Autor:
Peng Sheng Chen, James N. Weiss, Dechun Yin, Shuai Guo, Thomas H. Everett, Mu Chen, Zhenhui Chen, Shien-Fong Lin, Zhuo Wang, Michael Rubart-von der Lohe, Dongzhu Xu
Publikováno v:
The Journal of Physiology. 596:4299-4322
KEY POINTS: It is unknown if a sex difference exists in cardiac apamin‐sensitive small conductance Ca(2+)‐activated K(+) (SK) current (I (KAS)). There is no sex difference in I (KAS) in the basal condition. However, there is larger I (KAS) in fem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f6b904370a367f0a83e25a3a041331
https://doi.org/10.1113/jp275681
https://doi.org/10.1113/jp275681
Autor:
Frank A. Witzmann, Derrick E. Johnson, Andy Hudmon, Minghai Shao, Theodore R. Cummins, Tyler Shugg, Brian R. Overholser, Xianyin Lai, Michael Rubart-von der Lohe
Publikováno v:
Heart Rhythm. 15:895-904
Background Sustained β-adrenergic receptor (β-AR) stimulation causes pathophysiological changes during heart failure (HF), including inhibition of the slow component of the delayed rectifier potassium current (I Ks ). Aberrant calcium handling, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::590f334bb0d7efe1b8a8f4cc9d28675c
https://doi.org/10.1016/j.hrthm.2018.01.024
https://doi.org/10.1016/j.hrthm.2018.01.024
Autor:
Wei-Chung Tsai, Vickas V. Patel, Maria Kudela, Thomas H. Everett, Peng Sheng Chen, Po-Cheng Chang, Zhenhui Chen, Dhanendra Tomar, Changyu Shen, Yi Hsin Chan, Chia Hsiang Hsueh, Eue Keun Choi, Nicholas Anzalone, Michael A. Olaopa, Michael Rubart-von der Lohe, Shien-Fong Lin, Pooja Jadiya, Emily Luvison
Publikováno v:
Heart Rhythm. 13:1527-1535
Background The melanin synthesis enzyme dopachrome tautomerase (Dct) regulates intracellular Ca 2+ in melanocytes. Homozygous Dct knockout (Dct −/− ) adult mice are vulnerable to atrial arrhythmias (AA). Objective The purpose of this study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9466c1ef42a23bec7a7a551d40a790d
https://doi.org/10.1016/j.hrthm.2016.03.011
https://doi.org/10.1016/j.hrthm.2016.03.011