Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael Rotherham"'
Autor:
David Gothard, Michael Rotherham, Emma L. Smith, Janos M. Kanczler, James Henstock, Julia A. Wells, Carol A. Roberts, Omar Qutachi, Heather Peto, Hassan Rashidi, Luis Rojo, Lisa J. White, Molly M. Stevens, Alicia J. El Haj, Felicity R.A.J. Rose, Richard O.C. Oreffo
Publikováno v:
Mechanobiology in Medicine, Vol 2, Iss 4, Pp 100096- (2024)
Bone tissue engineering requires a combination of materials, cells, growth factors and mechanical cues to recapitulate bone formation. In this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with sk
Externí odkaz:
https://doaj.org/article/3563f34844174e618665c8ac5821cd93
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 21 (2023)
Bone regeneration and repair are complex processes in the adult skeleton, and current research has focused on understanding and controlling these processes. Magnetic nanoparticle (MNP)-based platforms have shown potential in tissue engineering and re
Externí odkaz:
https://doaj.org/article/59fd347e20c546e795e5cfc2ed66064d
Publikováno v:
Gels, Vol 9, Iss 11, p 915 (2023)
In the biomedical field, there is a demand for the development of novel approaches for the investigation of optical epithelial anatomical features with biomimetic materials. These materials are not only required to replicate structures but also enabl
Externí odkaz:
https://doaj.org/article/b6de878eb6f9435caa8e957d51aebb83
Autor:
Michael Rotherham, Yasamin Moradi, Tasmin Nahar, Dominic Mosses, Neil Telling, Alicia J. El Haj
Publikováno v:
Frontiers in Medical Technology, Vol 4 (2022)
TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter
Externí odkaz:
https://doaj.org/article/f622db2762c64d91b5373a94387c989b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3364 (2023)
This study reports results of a mechanical platform-based screening assay (MICA) to evaluate the remote activation of mechanosensitive ion channels. Here, we studied ERK pathway activation and the elevation in intracellular Ca2+ levels in response to
Externí odkaz:
https://doaj.org/article/2c0f28ff5965432e9eb0c8734cb36c1c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10164 (2022)
Wnt signaling plays an important role in embryogenesis and adult stem cell homeostasis. Its diminished activation is implicated in osteoporosis and degenerative neural diseases. However, systematic administration of Wnt-signaling agonists carries ris
Externí odkaz:
https://doaj.org/article/02725971dfd1461eb04d44ad8fe3c0fe
Publikováno v:
Stem Cell Reports, Vol 7, Iss 1, Pp 126-137 (2016)
The timing, location, and level of WNT signaling are highly regulated during embryonic development and for the maintenance of adult tissues. Consequently the ability to provide a defined and directed source of WNT proteins is crucial to fully underst
Externí odkaz:
https://doaj.org/article/a221cce8db884539b95e527a3404b02f
Publikováno v:
Journal of Tissue Engineering, Vol 9 (2018)
Magnetic ion channel activation technology uses superparamagnetic nanoparticles conjugated with targeting antibodies to apply mechanical force directly to stretch-activated ion channels on the cell surface, stimulating mechanotransduction and downstr
Externí odkaz:
https://doaj.org/article/893b4cc0ab5f43fa8de60510ef8184f0
Autor:
Michael Rotherham, Alicia J El Haj
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121761 (2015)
Wnt signalling pathways play crucial roles in developmental biology, stem cell fate and tissue patterning and have become an attractive therapeutic target in the fields of tissue engineering and regenerative medicine. Wnt signalling has also been sho
Externí odkaz:
https://doaj.org/article/25531af5b2064c2e851890b30747561d
Publikováno v:
Current Opinion in Biomedical Engineering. 24:100410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c81f8494fd08b13eb5b6253b83a60031
https://doi.org/10.1016/j.cobme.2022.100410
https://doi.org/10.1016/j.cobme.2022.100410