Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael Robert Peel"'
Autor:
Dongfang Meng, Dann L. Parker, Robin Kirwan, M A Powles, Jennifer Nielsen Kahn, James M. Apgar, Fred Racine, Paul A. Liberator, Amy M. Flattery, Andrew Galgoci, Kingsley H. Nelson, James M. Balkovec, Andrew S. Misura, Weiming Fan, Donald M. Sperbeck, Michael Robert Peel, Robert A. Giacobbe, Mark L. Greenlee, Ahmed Mamai, Jasminka Dragovic, Kenneth J. Wildonger, Hao Liu, Robert R. Wilkening, Mary Motyl, Shu Lee, Ming-Jo Hsu, Charles Gill, George K. Abruzzo
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
We previously reported medicinal chemistry efforts that identified MK-5204, an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a5b1dc4caa4f8e8040bb53f3f65ed
https://pubmed.ncbi.nlm.nih.gov/33160023
https://pubmed.ncbi.nlm.nih.gov/33160023
Autor:
James M. Balkovec, Robert A. Giacobbe, Jennifer Nielsen Kahn, Ming Jo Hsu, Weiming Fan, Ahmed Mamai, Michael Robert Peel, James M. Apgar, Amy M. Flattery, Paul A. Liberator, Fred Racine, Bahanu Habulihaz, Mary Motyl, Kingsley H. Nelson, Robert R. Wilkening, Robin Kirwan, M A Powles, George K. Abruzzo, Andrew Galgoci, Charles Gill, Andrew S. Misura, Shu Lee, Jasminka Dragovic, Hao Liu, Mark L. Greenlee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5813-5818
The clinical success of the echinocandins, which can only be administered parentally, has validated β-1,3-glucan synthase (GS) as an antifungal target. Semi-synthetic modification of enfumafungin, a triterpene glycoside natural product, was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f12625a2e82e86dbbc4c61aa3a8424
https://doi.org/10.1016/j.bmcl.2015.10.011
https://doi.org/10.1016/j.bmcl.2015.10.011
Autor:
Michael Robert Peel, Andrew Scribner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Cyclophilins (Cyps) are ubiquitous proteins that effect the cis–trans isomerization of Pro amide bonds, and are thus crucial to protein folding. CypA is the most prevalent of the ∼19 human Cyps, and plays a crucial role in
Cyclophilins (Cyps) are ubiquitous proteins that effect the cis–trans isomerization of Pro amide bonds, and are thus crucial to protein folding. CypA is the most prevalent of the ∼19 human Cyps, and plays a crucial role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271d1afe288ddceae2fe1b6047a5caf5
http://europepmc.org/articles/PMC7125669
http://europepmc.org/articles/PMC7125669
Autor:
Dann L. Parker, James M. Apgar, Robert A. Giacobbe, Ming Jo Hsu, Kingsley H. Nelson, Gregory J. Pacofsky, Paul A. Liberator, Fred Racine, Dongfang Meng, Ghjuvanni Coti, James M. Balkovec, Ahmed Mamai, Brian H. Heasley, Mark L. Greenlee, Jennifer Nielsen Kahn, Michael Robert Peel, Robert R. Wilkening, Hao Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6811-6816
Orally bioavailable inhibitors of β-(1,3)- d -glucan synthase have been pursued as new, broad-spectrum fungicidal therapies suitable for treatment in immunocompromised patients. Toward this end, a collaborative medicinal chemistry program was establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0eb37f90354231988b66512b32d5ce
https://doi.org/10.1016/j.bmcl.2012.05.031
https://doi.org/10.1016/j.bmcl.2012.05.031
Synthesis and biological evaluation of [d-lysine]8cyclosporin A analogs as potential anti-HCV agents
Autor:
Andrew Scribner, David Renwick Houck, Sarah Mosier, Michael Robert Peel, Zhuhui Huang, Bernard Scorneaux
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6542-6546
An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d888831e9243265ae9d2bb25c2d56fb
https://doi.org/10.1016/j.bmcl.2010.09.036
https://doi.org/10.1016/j.bmcl.2010.09.036
Autor:
James Marvin Veal, Robert J. Griffin, Jennifer G. Badiang Alberti, Daniel J. Price, Michael J. Reno, Anne M. Hassell, Michael Robert Peel, Lisa M. Shewchuk, Victoria B. Knick, Stephen T. Davis, Laurie S. Kane-Carson, Kirk L. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5758-5762
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280a1cb22c5d20e09331ae5b2631e585
https://doi.org/10.1016/j.bmcl.2008.09.069
https://doi.org/10.1016/j.bmcl.2008.09.069
Autor:
Andrew Scribner, Michael Robert Peel
Publikováno v:
ChemInform. 46
Background Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c734064d3cfde3d6e3946c0ff02b3e8
https://doi.org/10.1002/chin.201545247
https://doi.org/10.1002/chin.201545247
Autor:
Michael Robert Peel, Andrew Scribner
Publikováno v:
Biochimica et biophysica acta. 1850(10)
Background Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70753c8598297557855ecf2aff6c89d3
https://pubmed.ncbi.nlm.nih.gov/25707381
https://pubmed.ncbi.nlm.nih.gov/25707381
Autor:
Kristjan S. Gudmundsson, F. Leslie Boyd, Brian A. Johns, David Kendall Jung, Connie J. Sexton, Scott H. Allen, Michael Robert Peel, Elizabeth M. Turner
Publikováno v:
Tetrahedron. 59:9001-9011
Synthesis of a novel class of 7-amino-3-pyrimidinyl-pyrazolo[1,5-a]pyridine antiherpetic compounds is described. The synthetic methodology is designed to allow for rapid analog synthesis around the C-3 and C-7 positions of the pyrazolo[1,5-a]pyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1ba94656b82e6b35e6da02b65e8c99
https://doi.org/10.1016/j.tet.2003.02.003
https://doi.org/10.1016/j.tet.2003.02.003
Autor:
Stephen A. Stimpson, David Kendall Jung, Andrea H. Epperly, Michael Robert Peel, Mui Cheung, Michael J. Alberti, Stanley D. Chamberlain, Jennifer Gabriel Badiang, Philip A. Harris, Stephanie Harris, Neal H. Bramson, Peckham Gregory
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5428-5430
A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb95799ce4b8cbab3735d93a2dc8a3e
https://doi.org/10.1016/j.bmcl.2008.09.040
https://doi.org/10.1016/j.bmcl.2008.09.040