Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael Ringle"'
Autor:
Matt Timmers, Andi Kipper, Raphael Frey, Stef Notermans, Maksym Voievudskyi, Claire Wilson, Nina Hentzen, Michael Ringle, Clara Bovino, Bernhard Stump, Cristianne J. F. Rijcken, Tina Vermonden, Ingrid Dijkgraaf, Rob Liskamp
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1155 (2023)
The recently developed compound, tetramethylthiocycloheptyne sulfoximine (TMTHSI), has shown to be a promising strained alkyne for strain-promoted azide–alkyne cycloaddition (SPAAC), metal-free click chemistry. This research explores the properties
Externí odkaz:
https://doaj.org/article/9da70c47b33e40b898bbaddea38432fe
Autor:
Jonas De Breuck, Michael Streiber, Michael Ringleb, Dennis Schröder, Natascha Herzog, Ulrich S. Schubert, Stefan Zechel, Anja Traeger, Meike N. Leiske
Publikováno v:
ACS Polymers Au, Vol 4, Iss 3, Pp 222-234 (2024)
Externí odkaz:
https://doaj.org/article/c284606bf973411caa6f5296c0407fba
Publikováno v:
Biotechnology and Applied Biochemistry. 64:315-326
Escherichia coli has developed into an attractive organism for heterologous cytochrome P450 production, but, in some cases, was restricted as a host in view of a screening of orphan cytochromes P450 or mutant libraries in the context of molecular evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8302bed7ddf9fc0c76558f168a2c5343
https://doi.org/10.1002/bab.1488
https://doi.org/10.1002/bab.1488
Publikováno v:
FEBS Letters. 590:4638-4648
In this study, we report the crystal structure of the cytochrome P450 CYP260A1 (PDB 5LIV) from the myxobacterium Sorangium cellulosum So ce56. In addition, we investigated the hydroxylation of 11-deoxycorticosterone by CYP260A1 by reconstituting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faef2822b26b3787d52a58a35539006
https://doi.org/10.1002/1873-3468.12479
https://doi.org/10.1002/1873-3468.12479
Autor:
Andy-Mark W. H. Thunnissen, Yogan Khatri, Martin Litzenburger, Ilona K. Jóźwik, Michael Ringle, Rita Bernhardt, Michael C. Hutter, Irina Alexandra Ionescu
Publikováno v:
ACS chemical biology, 13(4), 1021-1028. AMER CHEMICAL SOC
The production of regio- and stereoselectively hydroxylated steroids is of high pharmaceutical interest and can be achieved by cytochrome P450-based biocatalysts. CYP260A1 from Sorangium cellulosum strain So ce56 catalyzes hydroxylation of C19 or C21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8fc6a3a05a56ceca33792b15feec87
https://research.rug.nl/en/publications/d307b1eb-2c45-4a41-9034-00fdc4f4594a
https://research.rug.nl/en/publications/d307b1eb-2c45-4a41-9034-00fdc4f4594a
Autor:
Vlada B. Urlacher, Michael Ringle, Marco Girhard, Rita Bernhardt, Frank Hannemann, Yogan Khatri, Emmanuelle Leize-Wagner, A. Meme, Simon Janocha, Reinhard Kappl
Publikováno v:
Biotechnology and Applied Biochemistry. 60:18-29
The members of the CYP109 family (CYP109C1, CYP109C2, and CYP109D1) from Sorangium cellulosum So ce56 are among the 21 P450 enzymes, of which only CYP109D1 and CYP264B1 have so far been functionally characterized. Here, we attempted to characterize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fa72053e6b9f5c29d39eabd5254b61a
https://doi.org/10.1002/bab.1087
https://doi.org/10.1002/bab.1087
Publikováno v:
Biotechnology and applied biochemistry. 64(3)
Escherichia coli has developed into an attractive organism for heterologous cytochrome P450 production, but, in some cases, was restricted as a host in view of a screening of orphan cytochromes P450 or mutant libraries in the context of molecular evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d8ed21a7a134ebf6d10b0dd00daf01f
https://pubmed.ncbi.nlm.nih.gov/26913738
https://pubmed.ncbi.nlm.nih.gov/26913738
Autor:
Michael Ringle, Michael Lisurek, Jens Peter von Kries, Yogan Khatri, Josef Zapp, Rita Bernhardt
Publikováno v:
Chembiochem : a European journal of chemical biology. 17(1)
Cytochromes P450 catalyze a variety of synthetically useful reactions. However, it is difficult to determine their physiological or artificial functions when a plethora of orphan P450 systems are present in a genome. CYP260A1 from Sorangium cellulosu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4055a1ece31493048f7d62f8b50a7620
https://pubmed.ncbi.nlm.nih.gov/26478560
https://pubmed.ncbi.nlm.nih.gov/26478560
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(18)
Sesquiterpenes are natural products derived from the common precursor farnesyl pyrophosphate (FPP) but are highly diverse in structure and function. Cytochrome P450 enzymes (P450s) exhibit the unique ability to introduce molecular oxygen into non-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8132a68c3ff39d96a210494a174d96
https://pubmed.ncbi.nlm.nih.gov/26449371
https://pubmed.ncbi.nlm.nih.gov/26449371
Publikováno v:
Applied microbiology and biotechnology. 97(17)
Cytochromes P450 monooxygenases are highly interesting biocatalysts for biotechnological applications, since they perform a diversity of reactions on a broad range of organic molecules. Nevertheless, the application of cytochromes P450 is limited com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c8490dec21f2d5e6f5a42c4e97becc
https://pubmed.ncbi.nlm.nih.gov/23254762
https://pubmed.ncbi.nlm.nih.gov/23254762