Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Michael Raymond Harnden"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2215-2218
A series of new 9-(4-phosphonobutoxy)purines was synthesized and evaluated as antiviral agents. 9-(4-Phosphonobutoxy)guanine displayed potent and selective activity against HIV-1 in peripheral blood lymphocytes.
Publikováno v:
Nucleosides and Nucleotides. 13:903-913
Suitably protected penciclovir, ganciclovir and 9-[3-hydroxy-2-(hydroxymethyl)propoxy]guanine were converted into their iodo-derivatives which in turn were reacted with trisodium thiophosphate to give the corresponding S-phosphates in good yields.
Publikováno v:
Antiviral Chemistry and Chemotherapy. 5:21-33
A number of 9-(hydroxyalkoxy) derivatives of guanine (27a-h and 27l-n) and of 8-methylguanine (27i-k) have been synthesized and evaluated as antiviral agents against herpes viruses (HSV-1, HSV-2, VZV) and visna virus, a lentivirus. The synthesis Invo
Publikováno v:
ChemInform. 28
A series of new 9-(4-phosphonobutoxy)purines was synthesized and evaluated as antiviral agents. 9-(4-Phosphonobutoxy)guanine displayed potent and selective activity against HIV-1 in peripheral blood lymphocytes.
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 22
Analogues of 2′,3′-dideoxynucleosides in which the tetrahydrofuran ring is replaced by a pyrrolidine ring linked to the base through an N–N bond have been prepared. The adenine 26, guanine 25 and hypoxanthine 27 compounds were synthesised via 9
Publikováno v:
ChemInform. 22
The synthesis and antiviral activity of a cyclopropyl analogue of the antiviral agent penciclovir is reported.
Publikováno v:
ChemInform. 23
The synthesis is described of the first members of a new class of nucleoside analogues in which the tetrahydrofuran ring is replaced by a pyrrolidine ring linked to the base through an N-N bond: the pyrrolidinyl analogues of 2′,3′-dideoxycytidine
Publikováno v:
ChemInform. 24
Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2′,3′-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanth